Glyphis may refer to:

• Glyphis (lichen), a genus of lichens in the family Graphidaceae
• Glyphis (shark), a genus of river sharks from Southeast Asia and Australia

• Hedwig Bienenfeld
• Hedwig Bilgram
• Hedwig, Duchess of Bavaria
• Hedwig Elizabeth Charlotte
• Hedwig Fassbender
• Hedwig Fountain
• Hedwig Friedländer
• Hedwig Grossman Lehmann
• Hedwigiales
• Hedwig Jagiellon (1457-1502)
• Hedwig Jagiellon (1513-1573)
• Hedwig Krüger
• Hedwig Langecker
• Hedwig Leenaert
• Hedwig Magdalena Simon
• Hedwig Maier-Reimer
• Hedwig of Eberhard
• Hedwig of Formbach
• Hedwig of Holstein-Gottorp
• Hedwig of Kalisz
• Hedwig of Mecklenburg-Gustrow
• Hedwig Rego
• Hedwig Röckelein
• Hedwig Voegt
• Hedwig (wife of Władysław Odonic)