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词条 GNA12
释义

  1. Interactions

  2. See also

  3. References

  4. External links

{{Infobox_gene}}Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.[1][2][3]

Interactions

GNA12 has been shown to interact with ARHGEF1,[4] PPP5C,[5] ARHGEF12,[6][7] HSP90[8], Resistance to inhibitors of cholinesterase-8A (Ric-8A) [9] and TEC.[7]

See also

  • G12/G13 alpha subunits
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References

1. ^{{cite journal | vauthors = Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA | title = Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product | journal = Molecular and Cellular Biology | volume = 13 | issue = 2 | pages = 762–8 | date = February 1993 | pmid = 8423800 | pmc = 358958 | doi = 10.1128/mcb.13.2.762}}
2. ^{{cite journal | vauthors = Kumar RN, Shore SK, Dhanasekaran N | title = Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3 | journal = Oncogene | volume = 25 | issue = 6 | pages = 899–906 | date = February 2006 | pmid = 16247467 | pmc = | doi = 10.1038/sj.onc.1209132 }}
3. ^{{cite web | title = Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2768| accessdate = }}
4. ^{{cite journal | vauthors = Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM | title = RGS16 inhibits signalling through the G alpha 13-Rho axis | journal = Nature Cell Biology | volume = 5 | issue = 12 | pages = 1095–103 | date = December 2003 | pmid = 14634662 | doi = 10.1038/ncb1065 }}
5. ^{{cite journal | vauthors = Yamaguchi Y, Katoh H, Mori K, Negishi M | title = Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity | journal = Current Biology | volume = 12 | issue = 15 | pages = 1353–8 | date = August 2002 | pmid = 12176367 | doi = 10.1016/S0960-9822(02)01034-5 }}
6. ^{{cite journal | vauthors = Fukuhara S, Chikumi H, Gutkind JS | title = Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho | journal = FEBS Letters | volume = 485 | issue = 2–3 | pages = 183–8 | date = November 2000 | pmid = 11094164 | doi = 10.1016/S0014-5793(00)02224-9 }}
7. ^{{cite journal | vauthors = Suzuki N, Nakamura S, Mano H, Kozasa T | title = Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 2 | pages = 733–8 | date = January 2003 | pmid = 12515866 | pmc = 141065 | doi = 10.1073/pnas.0234057100 }}
8. ^{{cite journal | vauthors = Vaiskunaite R, Kozasa T, Voyno-Yasenetskaya TA | title = Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling | journal = The Journal of Biological Chemistry | volume = 276 | issue = 49 | pages = 46088–93 | date = December 2001 | pmid = 11598136 | doi = 10.1074/jbc.M108711200 }}
9. ^{{cite journal | vauthors = Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY | title = Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization | journal = The Journal of Biological Chemistry | volume = 286 | issue = 35 | pages = 31055–61 | date = September 2011 | pmid = 21771786 | doi = 10.1074/jbc.M111.253427 | pmc=3162464}}

External links

  • {{MeshName|GNA12+protein,+human}}
{{PDB Gallery|geneid=2768}}{{Intracellular signaling peptides and proteins}}{{GTPases}}{{gene-7-stub}}
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