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词条 GNAZ
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}Guanine nucleotide-binding protein G(z) subunit alpha is a protein that in humans is encoded by the GNAZ gene.[1][2]

Function

The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systems. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids.[2]

Interactions

GNAZ has been shown to interact with EYA2,[3] RGS20[4][5] and RGS19.[3][6]

References

1. ^{{cite journal | vauthors = Matsuoka M, Itoh H, Kaziro Y | title = Characterization of the human gene for Gx alpha, a pertussis toxin-insensitive regulatory GTP-binding protein | journal = J. Biol. Chem. | volume = 265 | issue = 22 | pages = 13215–20 | date = September 1990 | pmid = 2115889 | pmc = | doi = }}
2. ^1 {{cite web | title = Entrez Gene: GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2781| accessdate = }}
3. ^1 {{cite journal | vauthors = Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR | title = The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins | journal = J. Biol. Chem. | volume = 275 | issue = 41 | pages = 32129–34 | date = October 2000 | pmid = 10906137 | doi = 10.1074/jbc.M004577200 }}
4. ^{{cite journal | vauthors = Nagahama M, Usui S, Shinohara T, Yamaguchi T, Tani K, Tagaya M | title = Inactivation of Galpha(z) causes disassembly of the Golgi apparatus | journal = J. Cell Sci. | volume = 115 | issue = Pt 23 | pages = 4483–93 | date = December 2002 | pmid = 12414994 | doi = 10.1242/jcs.00093 }}
5. ^{{cite journal | vauthors = Glick JL, Meigs TE, Miron A, Casey PJ | title = RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha | journal = J. Biol. Chem. | volume = 273 | issue = 40 | pages = 26008–13 | date = October 1998 | pmid = 9748279 | doi = 10.1074/jbc.273.40.26008 }}
6. ^{{cite journal | vauthors = De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG | title = GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 26 | pages = 15203–8 | date = December 1996 | pmid = 8986788 | pmc = 26381 | doi = 10.1073/pnas.93.26.15203 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI | title = Evolution of the mammalian G protein alpha subunit multigene family | journal = Nat. Genet. | volume = 1 | issue = 2 | pages = 85–91 | year = 1992 | pmid = 1302014 | doi = 10.1038/ng0592-85 }}
  • {{cite journal | vauthors = Jiang M, Pandey S, Tran VT, Fong HK | title = Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 88 | issue = 9 | pages = 3907–11 | year = 1991 | pmid = 1902575 | pmc = 51562 | doi = 10.1073/pnas.88.9.3907 }}
  • {{cite journal | vauthors = Gagnon AW, Manning DR, Catani L, Gewirtz A, Poncz M, Brass LF | title = Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes | journal = Blood | volume = 78 | issue = 5 | pages = 1247–53 | year = 1991 | pmid = 1908722 | doi = }}
  • {{cite journal | vauthors = Hinton DR, Blanks JC, Fong HK, Casey PJ, Hildebrandt E, Simons MI | title = Novel localization of a G protein, Gz-alpha, in neurons of brain and retina | journal = J. Neurosci. | volume = 10 | issue = 8 | pages = 2763–70 | year = 1990 | pmid = 2117645 | doi = }}
  • {{cite journal | vauthors = Mumby SM, Heukeroth RO, Gordon JI, Gilman AG | title = G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 87 | issue = 2 | pages = 728–32 | year = 1990 | pmid = 2153964 | pmc = 53339 | doi = 10.1073/pnas.87.2.728 }}
  • {{cite journal | vauthors = Matsuoka M, Itoh H, Kozasa T, Kaziro Y | title = Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 85 | issue = 15 | pages = 5384–8 | year = 1988 | pmid = 2456569 | pmc = 281761 | doi = 10.1073/pnas.85.15.5384 }}
  • {{cite journal | vauthors = Blatt C, Eversole-Cire P, Cohn VH, Zollman S, Fournier RE, Mohandas LT, Nesbitt M, Lugo T, Jones DT, Reed RR | title = Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 85 | issue = 20 | pages = 7642–6 | year = 1988 | pmid = 2902634 | pmc = 282248 | doi = 10.1073/pnas.85.20.7642 }}
  • {{cite journal | vauthors = Fong HK, Yoshimoto KK, Eversole-Cire P, Simon MI | title = Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 85 | issue = 9 | pages = 3066–70 | year = 1988 | pmid = 3129724 | pmc = 280144 | doi = 10.1073/pnas.85.9.3066 }}
  • {{cite journal | vauthors = Fields TA, Casey PJ | title = Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex | journal = J. Biol. Chem. | volume = 270 | issue = 39 | pages = 23119–25 | year = 1995 | pmid = 7559455 | doi = 10.1074/jbc.270.39.23119 }}
  • {{cite journal | vauthors = Lounsbury KM, Schlegel B, Poncz M, Brass LF, Manning DR | title = Analysis of Gz alpha by site-directed mutagenesis. Sites and specificity of protein kinase C-dependent phosphorylation | journal = J. Biol. Chem. | volume = 268 | issue = 5 | pages = 3494–8 | year = 1993 | pmid = 8429024 | doi = }}
  • {{cite journal | vauthors = Linder ME, Middleton P, Hepler JR, Taussig R, Gilman AG, Mumby SM | title = Lipid modifications of G proteins: alpha subunits are palmitoylated | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 90 | issue = 8 | pages = 3675–9 | year = 1993 | pmid = 8475115 | pmc = 46364 | doi = 10.1073/pnas.90.8.3675 }}
  • {{cite journal | vauthors = Hunt TW, Fields TA, Casey PJ, Peralta EG | title = RGS10 is a selective activator of G alpha i GTPase activity | journal = Nature | volume = 383 | issue = 6596 | pages = 175–7 | year = 1996 | pmid = 8774883 | doi = 10.1038/383175a0 }}
  • {{cite journal | vauthors = Magovcevic I, Khetarpal U, Bieber FR, Morton CC | title = GNAZ in human fetal cochlea: expression, localization, and potential role in inner ear function | journal = Hear. Res. | volume = 90 | issue = 1-2 | pages = 55–64 | year = 1995 | pmid = 8975005 | doi = 10.1016/0378-5955(95)00146-8 }}
  • {{cite journal | vauthors = De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG | title = GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 26 | pages = 15203–8 | year = 1996 | pmid = 8986788 | pmc = 26381 | doi = 10.1073/pnas.93.26.15203 }}
  • {{cite journal | vauthors = Ho MK, Wong YH | title = Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling | journal = J. Neurochem. | volume = 68 | issue = 6 | pages = 2514–22 | year = 1997 | pmid = 9166747 | doi = 10.1046/j.1471-4159.1997.68062514.x }}
  • {{cite journal | vauthors = Sidhu A, Kimura K, Uh M, White BH, Patel S | title = Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz | journal = J. Neurochem. | volume = 70 | issue = 6 | pages = 2459–67 | year = 1998 | pmid = 9603210 | doi = 10.1046/j.1471-4159.1998.70062459.x }}
  • {{cite journal | vauthors = Lin P, Le-Niculescu H, Hofmeister R, McCaffery JM, Jin M, Hennemann H, McQuistan T, De Vries L, Farquhar MG | title = The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein | journal = J. Cell Biol. | volume = 141 | issue = 7 | pages = 1515–27 | year = 1998 | pmid = 9647645 | pmc = 2132997 | doi = 10.1083/jcb.141.7.1515 }}
  • {{cite journal | vauthors = Glick JL, Meigs TE, Miron A, Casey PJ | title = RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha | journal = J. Biol. Chem. | volume = 273 | issue = 40 | pages = 26008–13 | year = 1998 | pmid = 9748279 | doi = 10.1074/jbc.273.40.26008 }}
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