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词条 GNB1
释义

  1. Function

  2. Interactive pathway map

  3. Interactions

  4. References

  5. Further reading

{{Infobox_gene}}Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene.[1]

Function

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.[1][2]

Interactive pathway map

{{NicotineDopaminergicActivity_WP1602|highlight=GNB1}}

Interactions

GNB1 has been shown to interact with GNG4.[3][4]

References

1. ^1 {{cite web | title = Entrez Gene: GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2782| accessdate = }}
2. ^{{cite journal | vauthors = Ogorodnikov A, Levin M, Tattikota S, Tokalov S, Hoque M, Scherzinger D, Marini F, Poetsch A, Binder H, Macher-Göppinger S, Probst HC, Tian B, Schaefer M, Lackner KJ, Westermann F, Danckwardt S | title = Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma. | journal = Nat. Commun. | volume = 9 | issue = 1 | pages = 5331 | date = December 2018 | pmid = 30552333 | doi = 10.1038/s41467-018-07580-5 }}
3. ^{{cite journal | vauthors = Ray K, Kunsch C, Bonner LM, Robishaw JD | title = Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits | journal = J. Biol. Chem. | volume = 270 | issue = 37 | pages = 21765–71 | date = September 1995 | pmid = 7665596 | doi = 10.1074/jbc.270.37.21765 }}
4. ^{{cite journal | vauthors = Yan K, Kalyanaraman V, Gautam N | title = Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families | journal = J. Biol. Chem. | volume = 271 | issue = 12 | pages = 7141–6 | date = March 1996 | pmid = 8636150 | doi = 10.1074/jbc.271.12.7141 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Downes GB, Gautam N | title = The G protein subunit gene families | journal = Genomics | volume = 62 | issue = 3 | pages = 544–52 | year = 1999 | pmid = 10644457 | doi = 10.1006/geno.1999.5992 }}
  • {{cite journal | vauthors = Levine MA, Modi WS, O'Brien SJ | title = Chromosomal localization of the genes encoding two forms of the G protein beta polypeptide, beta 1 and beta 3, in man | journal = Genomics | volume = 8 | issue = 2 | pages = 380–6 | year = 1990 | pmid = 1979057 | doi = 10.1016/0888-7543(90)90296-7 }}
  • {{cite journal | vauthors = Codina J, Stengel D, Woo SL, Birnbaumer L | title = Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical | journal = FEBS Lett. | volume = 207 | issue = 2 | pages = 187–92 | year = 1986 | pmid = 3095147 | doi = 10.1016/0014-5793(86)81486-7 }}
  • {{cite journal | vauthors = Buhl AM, Osawa S, Johnson GL | title = Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor | journal = J. Biol. Chem. | volume = 270 | issue = 34 | pages = 19828–32 | year = 1995 | pmid = 7649993 | doi = 10.1074/jbc.270.34.19828 }}
  • {{cite journal | vauthors = Ray K, Kunsch C, Bonner LM, Robishaw JD | title = Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits | journal = J. Biol. Chem. | volume = 270 | issue = 37 | pages = 21765–71 | year = 1995 | pmid = 7665596 | doi = 10.1074/jbc.270.37.21765 }}
  • {{cite journal | vauthors = Kozasa T, Gilman AG | title = Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha 12 and inhibition of adenylyl cyclase by alpha z | journal = J. Biol. Chem. | volume = 270 | issue = 4 | pages = 1734–41 | year = 1995 | pmid = 7829508 | doi = 10.1074/jbc.270.4.1734 }}
  • {{cite journal | vauthors = Tsukada S, Simon MI, Witte ON, Katz A | title = Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 91 | issue = 23 | pages = 11256–60 | year = 1994 | pmid = 7972043 | pmc = 45206 | doi = 10.1073/pnas.91.23.11256 }}
  • {{cite journal | vauthors = Ueda N, Iñiguez-Lluhi JA, Lee E, Smrcka AV, Robishaw JD, Gilman AG | title = G protein beta gamma subunits. Simplified purification and properties of novel isoforms | journal = J. Biol. Chem. | volume = 269 | issue = 6 | pages = 4388–95 | year = 1994 | pmid = 8308009 | doi = }}
  • {{cite journal | vauthors = Wall MA, Coleman DE, Lee E, Iñiguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR | title = The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2 | journal = Cell | volume = 83 | issue = 6 | pages = 1047–58 | year = 1995 | pmid = 8521505 | doi = 10.1016/0092-8674(95)90220-1 }}
  • {{cite journal | vauthors = Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB | title = Crystal structure of a G-protein beta gamma dimer at 2.1A resolution | journal = Nature | volume = 379 | issue = 6563 | pages = 369–74 | year = 1996 | pmid = 8552196 | doi = 10.1038/379369a0 }}
  • {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
  • {{cite journal | vauthors = Mattingly RR, Macara IG | title = Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits | journal = Nature | volume = 382 | issue = 6588 | pages = 268–72 | year = 1996 | pmid = 8717044 | doi = 10.1038/382268a0 }}
  • {{cite journal | vauthors = De Waard M, Liu H, Walker D, Scott VE, Gurnett CA, Campbell KP | title = Direct binding of G-protein betagamma complex to voltage-dependent calcium channels | journal = Nature | volume = 385 | issue = 6615 | pages = 446–50 | year = 1997 | pmid = 9009193 | doi = 10.1038/385446a0 }}
  • {{cite journal | vauthors = Huang CL, Jan YN, Jan LY | title = Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels | journal = FEBS Lett. | volume = 405 | issue = 3 | pages = 291–8 | year = 1997 | pmid = 9108307 | doi = 10.1016/S0014-5793(97)00197-X }}
  • {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
  • {{cite journal | vauthors = Qin N, Platano D, Olcese R, Stefani E, Birnbaumer L | title = Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 16 | pages = 8866–71 | year = 1997 | pmid = 9238069 | pmc = 23172 | doi = 10.1073/pnas.94.16.8866 }}
  • {{cite journal | vauthors = Nishida K, Kaziro Y, Satoh T | title = Association of the proto-oncogene product dbl with G protein betagamma subunits | journal = FEBS Lett. | volume = 459 | issue = 2 | pages = 186–90 | year = 1999 | pmid = 10518015 | doi = 10.1016/S0014-5793(99)01244-2 }}
  • {{cite journal | vauthors = Huang L, Shanker YG, Dubauskaite J, Zheng JZ, Yan W, Rosenzweig S, Spielman AI, Max M, Margolskee RF | title = Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium | journal = Nat. Neurosci. | volume = 2 | issue = 12 | pages = 1055–62 | year = 1999 | pmid = 10570481 | doi = 10.1038/15981 }}
  • {{cite journal | vauthors = Carman CV, Barak LS, Chen C, Liu-Chen LY, Onorato JJ, Kennedy SP, Caron MG, Benovic JL | title = Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2 | journal = J. Biol. Chem. | volume = 275 | issue = 14 | pages = 10443–52 | year = 2000 | pmid = 10744734 | doi = 10.1074/jbc.275.14.10443 }}
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