“GNG2”的意思、由来-开放百科全书

Heterotrimeric G proteins play vital roles in cellular responses to external signals. The specificity of a G protein-receptor interaction is primarily mediated by the gamma subunit.[supplied by OMIM]^[2]

References

1. ^{{cite journal |vauthors=Modarressi MH, Taylor KE, Wolfe J | title = Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit | journal = Biochem Biophys Res Commun | volume = 272 | issue = 2 | pages = 610–5 |date=Jul 2000 | pmid = 10833460 | pmc = | doi = 10.1006/bbrc.2000.2832 }}
2. ^¹{{cite web | title = Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54331| accessdate = }}

Further reading

{{cite journal | author=Pumiglia KM |title=A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase |journal=J. Biol. Chem. |volume=270 |issue= 24 |pages= 14251–4 |year= 1995 |pmid= 7782277 |doi=10.1074/jbc.270.24.14251 |name-list-format=vanc| author2=LeVine H | author3=Haske T | display-authors=3 | last4=Habib | first4=T | last5=Jove | first5=R | last6=Decker | first6=SJ }}

{{cite journal |vauthors=Tsukada S, Simon MI, Witte ON, Katz A |title=Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 23 |pages= 11256–60 |year= 1994 |pmid= 7972043 |doi=10.1073/pnas.91.23.11256 | pmc=45206 }}

{{cite journal |vauthors=Yan K, Kalyanaraman V, Gautam N |title=Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7141–6 |year= 1996 |pmid= 8636150 |doi=10.1074/jbc.271.12.7141 }}

{{cite journal | author=De Waard M |title=Direct binding of G-protein betagamma complex to voltage-dependent calcium channels |journal=Nature |volume=385 |issue= 6615 |pages= 446–50 |year= 1997 |pmid= 9009193 |doi= 10.1038/385446a0 |name-list-format=vanc| author2=Liu H | author3=Walker D | display-authors=3 | last4=Scott | first4=Victoria E. S. | last5=Gurnett | first5=Christina A. | last6=Campbell | first6=Kevin P. }}

{{cite journal |vauthors=Kostenis E, Conklin BR, Wess J |title=Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits |journal=Biochemistry |volume=36 |issue= 6 |pages= 1487–95 |year= 1997 |pmid= 9063897 |doi= 10.1021/bi962554d }}

{{cite journal | author=Qin N |title=Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 16 |pages= 8866–71 |year= 1997 |pmid= 9238069 |doi=10.1073/pnas.94.16.8866 | pmc=23172 |name-list-format=vanc| author2=Platano D | author3=Olcese R | display-authors=3 | last4=Stefani | first4=E | last5=Birnbaumer | first5=L }}

{{cite journal | author=Ong OC |title=Gene structure and chromosome localization of the G gamma c subunit of human cone G-protein (GNGT2) |journal=Genomics |volume=44 |issue= 1 |pages= 101–9 |year= 1997 |pmid= 9286705 |doi= 10.1006/geno.1997.4814 |name-list-format=vanc| author2=Hu K | author3=Rong H | display-authors=3 | last4=Lee | first4=Rehwa H. | last5=Fung | first5=Bernard K.-K. }}

{{cite journal |vauthors=Nishida K, Kaziro Y, Satoh T |title=Association of the proto-oncogene product dbl with G protein betagamma subunits |journal=FEBS Lett. |volume=459 |issue= 2 |pages= 186–90 |year= 1999 |pmid= 10518015 |doi=10.1016/S0014-5793(99)01244-2 }}

{{cite journal | author=Carman CV |title=Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2 |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10443–52 |year= 2000 |pmid= 10744734 |doi=10.1074/jbc.275.14.10443 |name-list-format=vanc| author2=Barak LS | author3=Chen C | display-authors=3 | last4=Liu-Chen | first4=LY | last5=Onorato | first5=JJ | last6=Kennedy | first6=SP | last7=Caron | first7=MG | last8=Benovic | first8=JL }}

{{cite journal |vauthors=Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB |title=Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23945–53 |year= 2001 |pmid= 11294873 |doi= 10.1074/jbc.M101154200 }}

{{cite journal | author=Yu Y |title=Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs |journal=Genome Res. |volume=11 |issue= 8 |pages= 1392–403 |year= 2001 |pmid= 11483580 |doi= 10.1101/gr.175501 | pmc=311073 |name-list-format=vanc| author2=Zhang C | author3=Zhou G | display-authors=3 | last4=Wu | first4=S | last5=Qu | first5=X | last6=Wei | first6=H | last7=Xing | first7=G | last8=Dong | first8=C | last9=Zhai | first9=Y }}

{{cite journal |vauthors=Lowry WE, Huang XY |title=G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1488–92 |year= 2002 |pmid= 11698416 |doi= 10.1074/jbc.M110390200 }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Cuello F |title=Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7220–6 |year= 2003 |pmid= 12486123 |doi= 10.1074/jbc.M210304200 |name-list-format=vanc| author2=Schulze RA | author3=Heemeyer F | display-authors=3 | last4=Meyer | first4=HE | last5=Lutz | first5=S | last6=Jakobs | first6=KH | last7=Niroomand | first7=F | last8=Wieland | first8=T }}

{{cite journal |vauthors=Melliti K, Grabner M, Seabrook GR |title=The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells |journal=J. Physiol. |volume=546 |issue= Pt 2 |pages= 337–47 |year= 2003 |pmid= 12527722 |doi=10.1113/jphysiol.2002.026716 | pmc=2342512 }}

{{cite journal | author=Wolfe JT |title=T-type calcium channel regulation by specific G-protein betagamma subunits |journal=Nature |volume=424 |issue= 6945 |pages= 209–13 |year= 2003 |pmid= 12853961 |doi= 10.1038/nature01772 |name-list-format=vanc| author2=Wang H | author3=Howard J | display-authors=3 | last4=Garrison | first4=James C. | last5=Barrett | first5=Paula Q. }}

{{cite journal | author=Niu J |title=G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production |journal=Circ. Res. |volume=93 |issue= 9 |pages= 848–56 |year= 2003 |pmid= 14512443 |doi= 10.1161/01.RES.0000097607.14733.0C |name-list-format=vanc| author2=Profirovic J | author3=Pan H | display-authors=3 | last4=Vaiskunaite | first4=R | last5=Voyno-Yasenetskaya | first5=T }}

{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }}

{{cite journal | author=Doering CJ |title=A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium channels |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29709–17 |year= 2004 |pmid= 15105422 |doi= 10.1074/jbc.M308693200 |name-list-format=vanc| author2=Kisilevsky AE | author3=Feng ZP | display-authors=3 | last4=Arnot | first4=MI | last5=Peloquin | first5=J | last6=Hamid | first6=J | last7=Barr | first7=W | last8=Nirdosh | first8=A | last9=Simms | first9=B }}

Interactive pathway map

References

Further reading