| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene.[1][2][3] It is found within the nucleolus that binds p53.[4] Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses.[4] It is a marker for many stem cells and cancer cells.[5] Interactions GNL3 has been shown to interact with Mdm2[6] and P53.[2] References 1. ^{{cite journal | vauthors = Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Laflin KJ, Gaddis S, MacLeod MC, Aldaz CM | title = Effects of estrogen on global gene expression: identification of novel targets of estrogen action | journal = Cancer Res. | volume = 60 | issue = 21 | pages = 5977–83 | date = Nov 2000 | pmid = 11085516 | pmc = | doi = }}
2. ^1 {{cite journal | vauthors = Tsai RY, McKay RD | title = A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells | journal = Genes Dev. | volume = 16 | issue = 23 | pages = 2991–3003 | date = Dec 2002 | pmid = 12464630 | pmc = 187487 | doi = 10.1101/gad.55671 }}
3. ^{{cite web | title = Entrez Gene: GNL3 guanine nucleotide binding protein-like 3 (nucleolar)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26354| accessdate = }}
4. ^1 {{Cite book | last1 = Ross | first1 = Michael H. | last2 = Pawlina | first2 = Wojciech. | title = Histology : a text and atlas : with correlated cell and molecular biolog | year = 2011 | publisher = Wolters Kluwer/Lippincott Williams Wilkins Health | location = Philadelphia | isbn = 978-0-7817-7200-6 | pages = 79 }}
5. ^{{cite book|author=Niall M. Adams|title=Advances in Nuclear Architecture|url=https://books.google.com/books?id=dpceD8fZ1B0C&pg=PA31|accessdate=27 September 2011|date=29 November 2010|publisher=Springer|isbn=978-90-481-9898-6|page=31}}
6. ^{{cite journal | vauthors = Dai MS, Sun XX, Lu H | title = Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2 | journal = Mol. Cell. Biol. | volume = 28 | issue = 13 | pages = 4365–76 | date = Jul 2008 | pmid = 18426907 | pmc = 2447154 | doi = 10.1128/MCB.01662-07 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
- {{cite journal | vauthors = Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ | title = Functional proteomic analysis of human nucleolus | journal = Mol. Biol. Cell | volume = 13 | issue = 11 | pages = 4100–9 | year = 2002 | pmid = 12429849 | pmc = 133617 | doi = 10.1091/mbc.E02-05-0271 }}
- {{cite journal | vauthors = Schwartz PH, Bryant PJ, Fuja TJ, Su H, O'Dowd DK, Klassen H | title = Isolation and characterization of neural progenitor cells from post-mortem human cortex | journal = J. Neurosci. Res. | volume = 74 | issue = 6 | pages = 838–51 | year = 2003 | pmid = 14648588 | doi = 10.1002/jnr.10854 }}
- {{cite journal | vauthors = Liu SJ, Cai ZW, Liu YJ, Dong MY, Sun LQ, Hu GF, Wei YY, Lao WD | title = Role of nucleostemin in growth regulation of gastric cancer, liver cancer and other malignancies | journal = World J. Gastroenterol. | volume = 10 | issue = 9 | pages = 1246–9 | year = 2004 | pmid = 15112336 | pmc = 4622760 | doi = 10.3748/wjg.v10.i9.1246}}
- {{cite journal | vauthors = Sijin L, Ziwei C, Yajun L, Meiyu D, Hongwei Z, Guofa H, Siguo L, Hong G, Zhihong Z, Xiaolei L, Yingyun W, Yan X, Weide L | title = The effect of knocking-down nucleostemin gene expression on the in vitro proliferation and in vivo tumorigenesis of HeLa cells | journal = J. Exp. Clin. Cancer Res. | volume = 23 | issue = 3 | pages = 529–38 | year = 2004 | pmid = 15595646 | doi = }}
- {{cite journal | vauthors = Tsai RY, McKay RD | title = A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin | journal = J. Cell Biol. | volume = 168 | issue = 2 | pages = 179–84 | year = 2005 | pmid = 15657390 | pmc = 2171593 | doi = 10.1083/jcb.200409053 }}
- {{cite journal | vauthors = Politz JC, Polena I, Trask I, Bazett-Jones DP, Pederson T | title = A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin | journal = Mol. Biol. Cell | volume = 16 | issue = 7 | pages = 3401–10 | year = 2005 | pmid = 15857956 | pmc = 1165421 | doi = 10.1091/mbc.E05-02-0106 }}
- {{cite journal | vauthors = Han C, Zhang X, Xu W, Wang W, Qian H, Chen Y | title = Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells | journal = Int. J. Mol. Med. | volume = 16 | issue = 2 | pages = 205–13 | year = 2005 | pmid = 16012751 | doi = 10.3892/ijmm.16.2.205 }}
- {{cite journal | vauthors = Yang HX, Jin GL, Meng L, Zhang JZ, Liu WB, Shou CC | title = Screening and identification of proteins interacting with nucleostemin | journal = World J. Gastroenterol. | volume = 11 | issue = 31 | pages = 4812–4 | year = 2005 | pmid = 16097049 | pmc = 4398727 | doi = 10.3748/wjg.v11.i31.4812}}
- {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
- {{cite journal | vauthors = Kafienah W, Mistry S, Williams C, Hollander AP | title = Nucleostemin is a marker of proliferating stromal stem cells in adult human bone marrow | journal = Stem Cells | volume = 24 | issue = 4 | pages = 1113–20 | year = 2006 | pmid = 16282439 | doi = 10.1634/stemcells.2005-0416 }}
- {{cite journal | vauthors = Fan Y, Liu Z, Zhao S, Lou F, Nilsson S, Ekman P, Xu D, Fang X | title = Nucleostemin mRNA is expressed in both normal and malignant renal tissues | journal = Br. J. Cancer | volume = 94 | issue = 11 | pages = 1658–62 | year = 2006 | pmid = 16670719 | pmc = 2361296 | doi = 10.1038/sj.bjc.6603145 }}
- {{cite journal | vauthors = Lacina L, Smetana K, Dvoránková B, Stork J, Plzáková Z, Gabius HJ | title = Immunocyto- and histochemical profiling of nucleostemin expression: marker of epidermal stem cells? | journal = J. Dermatol. Sci. | volume = 44 | issue = 2 | pages = 73–80 | year = 2006 | pmid = 17000083 | doi = 10.1016/j.jdermsci.2006.08.008 }}
- {{cite journal | vauthors = Zhu Q, Yasumoto H, Tsai RY | title = Nucleostemin delays cellular senescence and negatively regulates TRF1 protein stability | journal = Mol. Cell. Biol. | volume = 26 | issue = 24 | pages = 9279–90 | year = 2006 | pmid = 17000763 | pmc = 1698521 | doi = 10.1128/MCB.00724-06 }}
- {{cite journal | vauthors = Liu SJ, Zhang ZH, Zhang DQ, Sui XM, Liu YJ, Cai ZW, Yuan XY, Sun LQ, Hu GF, Liu RL | title = Gene profiling after knocking-down expression of nucleostemin in Hela cells using oligonucleotide DNA microarray | journal = J. Exp. Clin. Cancer Res. | volume = 25 | issue = 4 | pages = 575–83 | year = 2006 | pmid = 17310849 | doi = }}
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