“GPR12”的意思、由来-开放百科全书

The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity^[4].

References

1. ^{{cite journal |vauthors=Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T | title = Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system | journal = FEBS Lett | volume = 336 | issue = 2 | pages = 317–322 |date=Jan 1994 | pmid = 8262253 | pmc = | doi =10.1016/0014-5793(93)80828-I }}
2. ^{{cite journal |vauthors=Song ZH, Modi W, Bonner TI | title = Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors | journal = Genomics | volume = 28 | issue = 2 | pages = 347–349 |date=Feb 1996 | pmid = 8530049 | pmc = | doi = 10.1006/geno.1995.1154 }}
3. ^{{cite web | title = Entrez Gene: GPR12 G protein-coupled receptor 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2835| accessdate = }}
4. ^{{Cite journal| doi = 10.1016/j.bbrc.2006.07.090| issn = 0006-291X| volume = 348| issue = 2| pages = 359–366| last1 = Bjursell| first1 = Mikael| last2 = Gerdin| first2 = Anna-Karin| last3 = Jönsson| first3 = Marie| last4 = Surve| first4 = Vikas V.| last5 = Svensson| first5 = Lennart| last6 = Huang| first6 = Xu-Feng| last7 = Törnell| first7 = Jan| last8 = Bohlooly-Y| first8 = Mohammad| title = G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice| journal = Biochemical and Biophysical Research Communications| date = 2006-09-22| pmid = 16887097}}

Further reading

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Uhlenbrock K |title=Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells |journal=Cell. Physiol. Biochem. |volume=13 |issue= 2 |pages= 75–84 |year= 2003 |pmid= 12649592 |doi= 10.1159/000070251 |name-list-format=vanc| author2=Huber J | author3=Ardati A | display-authors=3 | last4=Busch | first4=Andreas | last5=Kostenis | first5=Evi }}

{{cite journal | author=Dunham A |title=The DNA sequence and analysis of human chromosome 13 |journal=Nature |volume=428 |issue= 6982 |pages= 522–528 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 |name-list-format=vanc| author2=Matthews LH | author3=Burton J | display-authors=3 | last4=Ashurst | first4=J. L. | last5=Howe | first5=K. L. | last6=Ashcroft | first6=K. J. | last7=Beare | first7=D. M. | last8=Burford | first8=D. C. | last9=Hunt | first9=S. E. }}

{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

1 : G protein-coupled receptors