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词条 GPR120
释义

  1. References

  2. Further reading

{{Infobox_gene}}G-protein coupled receptor 120 is a protein that in humans is encoded by the GPR120 gene.[1][2]

GPR120 is a member of the rhodopsin family of G protein-coupled receptors (GPRs).[1][2]

GPR120 has also been shown to mediate the anti-inflammatory and insulin-sensitizing effects of omega 3 fatty acids.[3] Lack of GPR120 is responsible for reduced fat metabolism, thereby leading to obesity.[4]

Additionally, GPR120 has been implicated to be involved in the ability to taste fats.[5] It is expressed in taste bud cells (specifically cell type II, which contain other G-protein coupled taste receptors), and its absence leads to reduced preference to two types of fatty acid (linoleic acid and oleic acid), as well as decreased neuronal response to oral fatty acids.[6]

References

1. ^1 {{cite journal |vauthors=Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB | title = Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives | journal = FEBS Lett | volume = 554 | issue = 3 | pages = 381–8 | date = Nov 2003 | pmid = 14623098 | pmc = | doi = 10.1016/S0014-5793(03)01196-7 }}
2. ^1 {{cite web | title = Entrez Gene: GPR120 G protein-coupled receptor 120| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=338557| accessdate = }}
3. ^{{cite journal |vauthors=Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM, Olefsky JM | title = GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects | journal = Cell | volume = 142 | issue = 5 | pages = 687–698 | year = 2010 | pmid = 20813258 | pmc = 2956412 | doi = 10.1016/j.cell.2010.07.041 }}
4. ^{{cite journal |vauthors=Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L | title = Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human | journal = Nature | volume = 483 | issue = 7389 | pages = 350–4 | year = 2012 | pmid = 22343897 | doi = 10.1038/nature10798 |display-authors=etal}}
5. ^{{pmid|24631296}}
6. ^{{pmid| 20573884}}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA | title = The G protein-coupled receptor repertoires of human and mouse | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 8 | pages = 4903–8 | year = 2003 | pmid = 12679517 | pmc = 153653 | doi = 10.1073/pnas.0230374100 }}
  • {{cite journal |vauthors=Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, Sugimoto Y, Miyazaki S, Tsujimoto G | title = Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 | journal = Nat. Med. | volume = 11 | issue = 1 | pages = 90–4 | year = 2005 | pmid = 15619630 | doi = 10.1038/nm1168 }}
  • {{cite journal |vauthors=Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS | title = Transcriptome analysis of human gastric cancer | journal = Mamm. Genome | volume = 16 | issue = 12 | pages = 942–54 | year = 2006 | pmid = 16341674 | doi = 10.1007/s00335-005-0075-2 }}
{{refend}}{{G protein-coupled receptors}}{{transmembranereceptor-stub}}

1 : G protein-coupled receptors
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