“GPR182”的意思、由来-开放百科全书

When this gene was first cloned, it was proposed to encode an adrenomedullin receptor.^[2] However, when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM).^[3]

It was subsequently shown that a different GPCR, CALCRL when complexed with RAMP2 can function as an ADM receptor.^[4]

References

1. ^{{cite journal |vauthors=Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA | title = The G protein-coupled receptor repertoires of human and mouse | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 8 | pages = 4903–4908 |date=April 2003 | pmid = 12679517 | pmc = 153653 | doi = 10.1073/pnas.0230374100 | url = }}
2. ^{{cite journal |vauthors=Hänze J, Dittrich K, Dötsch J, Rascher W | title = Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system | journal = Biochem. Biophys. Res. Commun. | volume = 240 | issue = 1 | pages = 183–188 |date=November 1997 | pmid = 9367907 | doi = 10.1006/bbrc.1997.7631 | url = }}
3. ^{{cite journal |vauthors=Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ | title = Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response | journal = Biochem. Biophys. Res. Commun. | volume = 244 | issue = 3 | pages = 832–837 |date=March 1998 | pmid = 9535752 | doi = 10.1006/bbrc.1998.8349 | url = }}
4. ^{{cite journal |vauthors=McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM | title = RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor | journal = Nature | volume = 393 | issue = 6683 | pages = 333–339 |date=May 1998 | pmid = 9620797 | doi = 10.1038/30666 | url = }}

Further reading

{{cite journal |vauthors=Lah JJ, Frishman WH |title=Adrenomedullin: a vasoactive and natriuretic peptide with therapeutic potential |journal=Heart Disease (Hagerstown, Md.) |volume=2 |issue= 3 |pages= 259–65 |year= 2002 |pmid= 11728267 |doi= }}

{{cite journal | author=Mukoyama M |title=Role of adrenomedullin and its receptor system in renal pathophysiology |journal=Peptides |volume=22 |issue= 11 |pages= 1925–1931 |year= 2002 |pmid= 11754983 |doi=10.1016/S0196-9781(01)00525-3 |name-list-format=vanc| author2=Sugawara A | author3=Nagae T | display-authors=3 | last4=Mori | first4=K | last5=Murabe | first5=H | last6=Itoh | first6=H | last7=Tanaka | first7=I | last8=Nakao | first8=K }}

{{cite journal |vauthors=Fowler DE, Wang P |title=The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review) |journal=Int. J. Mol. Med. |volume=9 |issue= 5 |pages= 443–9 |year= 2002 |pmid= 11956648 |doi= 10.3892/ijmm.9.5.443}}

{{cite journal |vauthors=Kato J, Kitamura K, Kangawa K, Eto T |title=Receptors for adrenomedullin in human vascular endothelial cells |journal=Eur. J. Pharmacol. |volume=289 |issue= 2 |pages= 383–385 |year= 1995 |pmid= 7621913 |doi=10.1016/0922-4106(95)90117-5 }}

{{cite journal |vauthors=Martínez A, Miller MJ, Catt KJ, Cuttitta F |title=Adrenomedullin receptor expression in human lung and in pulmonary tumors |journal=J. Histochem. Cytochem. |volume=45 |issue= 2 |pages= 159–64 |year= 1997 |pmid= 9016306 |doi=10.1177/002215549704500202 }}

{{cite journal |vauthors=Hänze J, Dittrich K, Dötsch J, Rascher W |title=Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system |journal=Biochem. Biophys. Res. Commun. |volume=240 |issue= 1 |pages= 183–188 |year= 1997 |pmid= 9367907 |doi= 10.1006/bbrc.1997.7631 }}

{{cite journal | author=Martínez A |title=Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument |journal=Endocrinology |volume=138 |issue= 12 |pages= 5597–5604 |year= 1997 |pmid= 9389548 |doi=10.1210/en.138.12.5597 |name-list-format=vanc| author2=Elsasser TH | author3=Muro-Cacho C | display-authors=3 | last4=Moody | first4=TW | last5=Miller | first5=MJ | last6=Macri | first6=CJ | last7=Cuttitta | first7=F }}

{{cite journal | author=Kennedy SP |title=Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response |journal=Biochem. Biophys. Res. Commun. |volume=244 |issue= 3 |pages= 832–837 |year= 1998 |pmid= 9535752 |doi= 10.1006/bbrc.1998.8349 |name-list-format=vanc| author2=Sun D | author3=Oleynek JJ | display-authors=3 | last4=Hoth | first4=CF | last5=Kong | first5=J | last6=Hill | first6=RJ }}

{{cite journal | author=Jiménez N |title=Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in human and rat prostate |journal=J. Histochem. Cytochem. |volume=47 |issue= 9 |pages= 1167–78 |year= 1999 |pmid= 10449538 |doi=10.1177/002215549904700909 |name-list-format=vanc| author2=Calvo A | author3=Martínez A | display-authors=3 | last4=Rosell | first4=D | last5=Cuttitta | first5=F | last6=Montuenga | first6=LM }}

{{cite journal | author=Kuwasako K |title=The seven amino acids of human RAMP2 (86) and RAMP3 (59) are critical for agonist binding to human adrenomedullin receptors |journal=J. Biol. Chem. |volume=276 |issue= 52 |pages= 49459–49465 |year= 2002 |pmid= 11591721 |doi= 10.1074/jbc.M108369200 |name-list-format=vanc| author2=Kitamura K | author3=Ito K | display-authors=3 | last4=Uemura | first4=T | last5=Yanagita | first5=Y | last6=Kato | first6=J | last7=Sakata | first7=T | last8=Eto | first8=T }}

{{cite journal | author=Forneris M |title=Expression and function of adrenomedullin and its receptors in Conn's adenoma cells |journal=Int. J. Mol. Med. |volume=8 |issue= 6 |pages= 675–9 |year= 2002 |pmid= 11712085 |doi= 10.3892/ijmm.8.6.675|name-list-format=vanc| author2=Gottardo L | author3=Albertin G | display-authors=3 | last4=Malendowicz | first4=LK | last5=Nussdorfer | first5=GG }}

{{cite journal | author=Hänze J |title=Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue= 5 |pages= 1160–1165 |year= 2002 |pmid= 11883938 |doi= 10.1006/bbrc.2002.6595 |name-list-format=vanc| author2=Groneberg DA | author3=Rose F | display-authors=3 | last4=Hanisch | first4=A | last5=Dötsch | first5=J | last6=Peiser | first6=C | last7=Seeger | first7=W | last8=Rascher | first8=W | last9=Fischer | first9=A }}

{{cite journal | author=Dumont CE |title=Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats |journal=Brain Res. |volume=955 |issue= 1–2 |pages= 64–71 |year= 2003 |pmid= 12419522 |doi=10.1016/S0006-8993(02)03365-6 |name-list-format=vanc| author2=Muff R | author3=Flühmann B | display-authors=3 | last4=Fischer | first4=JA | last5=Born | first5=W }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Chosa E |title=Expression of adrenomedullin and its receptor by chondrocyte phenotype cells |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 1 |pages= 379–386 |year= 2003 |pmid= 12646214 |doi=10.1016/S0006-291X(03)00347-4 |name-list-format=vanc| author2=Hamada H | author3=Kitamura K | display-authors=3 | last4=Kuwasako | first4=Kenji | last5=Yanagita | first5=Toshihiko | last6=Eto | first6=Tanenao | last7=Tajima | first7=Naoya }}

{{cite journal | author=Xu P |title=[Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease] |journal=Zhonghua Jie He He Hu Xi Za Zhi |volume=26 |issue= 12 |pages= 765–8 |year= 2004 |pmid= 14720432 |doi= |name-list-format=vanc| author2=Dai AG | author3=Zhou HD | display-authors=3 | last4=Shen | first4=HW | last5=Liu | first5=LH | last6=Song | first6=WD }}

{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

External links

{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3070 | title = GPR182 | date = 2007-12-04 | format = | work = IUPHAR GPCR Database | publisher = International Union of Pharmacology (IUPHAR) | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2008-07-03}}

1 : G protein-coupled receptors