| 词条 | GPR3 |
| 释义 |
G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene.[1][2] The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction. FunctionGPR3 activates adenylate cyclase in the absence of ligand.[3] GPR3 is expressed in mammalian oocytes where it maintains meiotic arrest and is thought to be a communication link between oocytes and the surrounding somatic tissue.[4] It has been proposed that sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) are GPR3 ligands,[5][6] however this result was not confirmed in a β-arrestin recruitment assay.[7] References1. ^{{cite journal |vauthors=Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF | title = Cloning of human genes encoding novel G protein-coupled receptors | journal = Genomics | volume = 23 | issue = 3 | pages = 609–18 |date=Mar 1995 | pmid = 7851889 | pmc = | doi = 10.1006/geno.1994.1549 }} 2. ^{{Cite web| title = Entrez Gene: GPR3 G protein-coupled receptor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2827| accessdate = }} 3. ^{{cite journal |vauthors=Eggerickx D, Denef JF, Labbe O, Hayashi Y, Refetoff S, Vassart G, Parmentier M, Libert F | title = Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase | journal = Biochem. J. | volume = 309 ( Pt 3) | issue = Pt 3| pages = 837–43 |date=August 1995 | pmid = 7639700 | pmc = 1135708 | url = }} 4. ^{{cite journal |vauthors=Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA |title = The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes | journal = Science |volume = 306 | issue = 5703 | pages = 1947–50 |date=December 2004 | pmid = 15591206 | doi = 10.1126/science.1103974 | url = }} 5. ^{{cite journal |vauthors=Uhlenbrock K, Gassenhuber H, Kostenis E | title = Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors | journal = Cell. Signal. | volume = 14 | issue = 11 | pages = 941–53 |date=November 2002 | pmid = 12220620 | doi = 10.1016/S0898-6568(02)00041-4| url = }} 6. ^{{cite journal |vauthors=Hinckley M, Vaccari S, Horner K, Chen R, Conti M | title = The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes | journal = Dev. Biol. | volume = 287 | issue = 2 | pages = 249–61 |date=November 2005 | pmid = 16229830 | doi = 10.1016/j.ydbio.2005.08.019 | url = }} 7. ^{{cite journal |vauthors=Yin H, Chu A, Li W, Wang B, Shelton F, Otero F, Nguyen DG, Caldwell JS, Chen YA | title = Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay | journal = J. Biol. Chem. | volume = 284 | issue = 18 | pages = 12328–38 |date=May 2009 | pmid = 19286662 | pmc = 2673301 | doi = 10.1074/jbc.M806516200 | url = }} Further reading{{Refbegin| 2}}
1 : G protein-coupled receptors |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。