1. Function

2. Interactions

3. References

4. Further reading

Function

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.^[2]

Interactions

GPS2 (gene) has been shown to interact with:

• C21orf7,^[3]
• Cyclin A1,^[4]
• EP300,^[5]
• HDAC3,^[7]
• NCOR1,^[7][6][7]
• P53,^[8] and
• TBL1X.^[9]

References

Further reading

• {{cite journal | vauthors = Jin DY, Teramoto H, Giam CZ, Chun RF, Gutkind JS, Jeang KT | title = A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha | journal = The Journal of Biological Chemistry | volume = 272 | issue = 41 | pages = 25816–23 | date = Oct 1997 | pmid = 9325311 | doi = 10.1074/jbc.272.41.25816 }}
• {{cite journal | vauthors = Peng YC, Breiding DE, Sverdrup F, Richard J, Androphy EJ | title = AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins | journal = Journal of Virology | volume = 74 | issue = 13 | pages = 5872–9 | date = Jul 2000 | pmid = 10846067 | pmc = 112082 | doi = 10.1128/JVI.74.13.5872-5879.2000 }}
• {{cite journal | vauthors = Degenhardt YY, Silverstein SJ | title = Gps2, a protein partner for human papillomavirus E6 proteins | journal = Journal of Virology | volume = 75 | issue = 1 | pages = 151–60 | date = Jan 2001 | pmid = 11119584 | pmc = 113908 | doi = 10.1128/JVI.75.1.151-160.2001 }}
• {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
• {{cite journal | vauthors = Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 8 | issue = 2 | pages = 85–95 | date = Apr 2001 | pmid = 11347906 | doi = 10.1093/dnares/8.2.85 }}
• {{cite journal | vauthors = Peng YC, Kuo F, Breiding DE, Wang YF, Mansur CP, Androphy EJ | title = AMF1 (GPS2) modulates p53 transactivation | journal = Molecular and Cellular Biology | volume = 21 | issue = 17 | pages = 5913–24 | date = Sep 2001 | pmid = 11486030 | pmc = 87310 | doi = 10.1128/MCB.21.17.5913-5924.2001 }}
• {{cite journal | vauthors = Zhang J, Kalkum M, Chait BT, Roeder RG | title = The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 | journal = Molecular Cell | volume = 9 | issue = 3 | pages = 611–23 | date = Mar 2002 | pmid = 11931768 | doi = 10.1016/S1097-2765(02)00468-9 }}
• {{cite journal | vauthors = Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J | title = Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1 | journal = The EMBO Journal | volume = 22 | issue = 6 | pages = 1336–46 | date = Mar 2003 | pmid = 12628926 | pmc = 151047 | doi = 10.1093/emboj/cdg120 }}
• {{cite journal | vauthors = Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J | title = N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso | journal = Molecular Cell | volume = 12 | issue = 3 | pages = 723–34 | date = Sep 2003 | pmid = 14527417 | doi = 10.1016/j.molcel.2003.08.008 }}
• {{cite journal | vauthors = Diederichs S, Bäumer N, Ji P, Metzelder SK, Idos GE, Cauvet T, Wang W, Möller M, Pierschalski S, Gromoll J, Schrader MG, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C | title = Identification of interaction partners and substrates of the cyclin A1-CDK2 complex | journal = The Journal of Biological Chemistry | volume = 279 | issue = 32 | pages = 33727–41 | date = Aug 2004 | pmid = 15159402 | doi = 10.1074/jbc.M401708200 }}
• {{cite journal | vauthors = Lee TH, Yi W, Griswold MD, Zhu F, Her C | title = Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment | journal = DNA Repair | volume = 5 | issue = 1 | pages = 32–42 | date = Jan 2006 | pmid = 16122992 | doi = 10.1016/j.dnarep.2005.07.004 }}
• {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
• {{cite journal | vauthors = Sanyal S, Båvner A, Haroniti A, Nilsson LM, Lundåsen T, Rehnmark S, Witt MR, Einarsson C, Talianidis I, Gustafsson JA, Treuter E | title = Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 40 | pages = 15665–70 | date = Oct 2007 | pmid = 17895379 | pmc = 2000397 | doi = 10.1073/pnas.0706736104 }}

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