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词条 GPX5
释义

  1. References

  2. Further reading

{{Infobox_gene}}Glutathione peroxidase 5 (GPx-5), also known as epididymal secretory glutathione peroxidase is an enzyme that in humans is encoded by the GPX5 gene.[1][2]

GPx-5 belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[1]

References

1. ^1 {{cite web | title = Entrez Gene: glutathione peroxidase 5 (epididymal androgen-related protein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2880| accessdate = }}
2. ^{{cite journal |vauthors=Hall L, Williams K, Perry AC, Frayne J, Jury JA | title = The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract | journal = Biochem. J. | volume = 333 | issue = 1| pages = 5–9 |date=July 1998 | pmid = 9639555 | pmc = 1219548 | doi = | url = | issn = }}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Talmud PJ, Drenos F, Shah S, etal |title=Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. |journal=Am. J. Hum. Genet. |volume=85 |issue= 5 |pages= 628–42 |year= 2009 |pmid= 19913121 |doi= 10.1016/j.ajhg.2009.10.014 |pmc=2775832}}
  • {{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
  • {{cite journal |vauthors=Perry AC, Jones R, Niang LS, etal |title=Genetic evidence for an androgen-regulated epididymal secretory glutathione peroxidase whose transcript does not contain a selenocysteine codon. |journal=Biochem. J. |volume=285 |issue= 3|pages= 863–70 |year= 1992 |pmid= 1386734 |doi= |pmc=1132876}}
  • {{cite journal |vauthors=Richard MJ, Guiraud P, Didier C, etal |title=Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation. |journal=Arch. Biochem. Biophys. |volume=386 |issue= 2 |pages= 213–20 |year= 2001 |pmid= 11368344 |doi= 10.1006/abbi.2000.2197 }}
  • {{cite journal |vauthors=Opalenik SR, Ding Q, Mallery SR, Thompson JA |title=Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor. |journal=Arch. Biochem. Biophys. |volume=351 |issue= 1 |pages= 17–26 |year= 1998 |pmid= 9501919 |doi= 10.1006/abbi.1997.0566 }}
  • {{cite journal |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2000 |pmid= 11076863 |doi= 10.1101/gr.143000 |pmc=310948}}
  • {{cite journal |vauthors=Rejraji H, Vernet P, Drevet JR |title=GPX5 is present in the mouse caput and cauda epididymidis lumen at three different locations. |journal=Mol. Reprod. Dev. |volume=63 |issue= 1 |pages= 96–103 |year= 2002 |pmid= 12211066 |doi= 10.1002/mrd.10136 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
  • {{cite journal |vauthors=Choi J, Liu RM, Kundu RK, etal |title=Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3693–8 |year= 2000 |pmid= 10652368 |doi= 10.1074/jbc.275.5.3693}}
  • {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 |pmc=1356129}}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241}}
  • {{cite journal |vauthors=Vernet P, Faure J, Dufaure JP, Drevet JR |title=Tissue and developmental distribution, dependence upon testicular factors and attachment to spermatozoa of GPX5, a murine epididymis-specific glutathione peroxidase. |journal=Mol. Reprod. Dev. |volume=47 |issue= 1 |pages= 87–98 |year= 1997 |pmid= 9110319 |doi= 10.1002/(SICI)1098-2795(199705)47:1<87::AID-MRD12>3.0.CO;2-X }}
  • {{cite journal |vauthors=Price TO, Ercal N, Nakaoke R, Banks WA |title=HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells. |journal=Brain Res. |volume=1045 |issue= 1-2 |pages= 57–63 |year= 2005 |pmid= 15910762 |doi= 10.1016/j.brainres.2005.03.031 }}
  • {{cite journal |vauthors=Williams K, Frayne J, Hall L |title=Expression of extracellular glutathione peroxidase type 5 (GPX5) in the rat male reproductive tract. |journal=Mol. Hum. Reprod. |volume=4 |issue= 9 |pages= 841–8 |year= 1998 |pmid= 9783843 |doi= 10.1093/molehr/4.9.841 }}
  • {{cite journal |vauthors=Bailey SD, Xie C, Do R, etal |title=Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. |journal=Diabetes Care |volume=33 |issue= 10 |pages= 2250–3 |year= 2010 |pmid= 20628086 |doi= 10.2337/dc10-0452 |pmc=2945168}}
  • {{cite journal |vauthors=Moyer AM, Sun Z, Batzler AJ, etal |title=Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=19 |issue= 3 |pages= 811–21 |year= 2010 |pmid= 20200426 |doi= 10.1158/1055-9965.EPI-09-0871 |pmc=2837367}}
{{refend}}{{Peroxidases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{gene-6-stub}}

2 : EC 1.11.1|Antioxidants
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