| 词条 | Grandinin |
| 释义 |
| Watchedfields = changed | verifiedrevid = 441141120 | Name = Grandinin | ImageFile = Grandinin.PNG | ImageName = Chemical structure of grandinin | IUPACName = | OtherNames = |Section1={{Chembox Identifiers | CASNo_Ref = {{cascite|correct|??}} | CASNo = 115166-32-0 | CASNoOther = | PubChem = 492392 | SMILES = C1C2C(C3C4C(C5=C(C(=C(C(=C5C(=O)O4)C6=C(C(=C(C(=C6C(=O)O3)C7=C(C(=C(C=C7C(=O)O2)O)O)O)O)O)O)O)O)O)C8(C(C(C(O8)CO)O)O)O)OC(=O)C9=CC(=C(C(=C9C2=C(C(=C(C=C2C(=O)O1)O)O)O)O)O)O | InChI = | MeSHName = }} |Section2={{Chembox Properties | Formula = C46H34O30 | MolarMass = 1066.74 g/mol | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} }} Grandinin is an ellagitannin. It can be found in Melaleuca quinquenervia leaves[1] and in oaks species like the North American white oak (Quercus alba) and European red oak (Quercus robur).[2] It shows antioxydant activity.[1] It is an astringent compound.[4] It is also found in wine, red[3] or white,[4] aged in oak barrels. It is a castalagin glycoside[5] by binding of the pentose lyxose.[6] It contains a nonahydroxytriphenic acid moiety. It suppresses the phosphorylation of the epidermal growth factor receptor in human colon carcinoma cells.[5] See also
References1. ^1 Polyphenols of Melaleuca quinquenervia leaves - pharmacological studies of grandinin. Moharram F. A., Marzouk M. S., El-Toumy S. A. A., Ahmed A. A. E. and Aboutabl E. A., Phytotherapy Research, Volume 17 Issue 7, Pages 767-773, {{doi|10.1002/ptr.1214}} {{Ellagitannin}}{{Growth factor receptor modulators}}{{Natural-phenol-stub}}2. ^{{Cite journal | last1 = Mämmelä | first1 = P. | last2 = Savolainen | first2 = H. | last3 = Lindroos | first3 = L. | last4 = Kangas | first4 = J. | last5 = Vartiainen | first5 = T. | title = Analysis of oak tannins by liquid chromatography-electrospray ionisation mass spectrometry | doi = 10.1016/S0021-9673(00)00624-5 | journal = Journal of Chromatography A | volume = 891 | issue = 1 | pages = 75–83 | year = 2000 | pmid = 10999626| pmc = }} 3. ^{{Cite journal | last1 = García-Estévez | first1 = I. | last2 = Escribano-Bailón | first2 = M. T. | last3 = Rivas-Gonzalo | first3 = J. N. C. | last4 = Alcalde-Eon | first4 = C. | title = Development of a fractionation method for the detection and identification of oak ellagitannins in red wines | doi = 10.1016/j.aca.2009.10.020 | journal = Analytica Chimica Acta | volume = 660 | issue = 1–2 | pages = 171–176 | year = 2010 | pmid = 20103159 | pmc = }} 4. ^{{Cite journal | last1 = Marinov | first1 = M. G. | last2 = Dimitrova | first2 = E. D. | last3 = Puech | first3 = J. ‐L. | title = Kinetics of ellagitannin extraction from oak wood using white wine | doi = 10.1080/09571269708718095 | journal = Journal of Wine Research | volume = 8 | pages = 29 | year = 1997 | pmid = | pmc = }} 5. ^1 {{Cite journal | last1 = Fridrich | first1 = D. | last2 = Glabasnia | first2 = A. | last3 = Fritz | first3 = J. | last4 = Esselen | first4 = M. | last5 = Pahlke | first5 = G. | last6 = Hofmann | first6 = T. | last7 = Marko | first7 = D. | doi = 10.1021/jf073427z | title = Oak Ellagitannins Suppress the Phosphorylation of the Epidermal Growth Factor Receptor in Human Colon Carcinoma Cells | journal = Journal of Agricultural and Food Chemistry | volume = 56 | issue = 9 | pages = 3010–3015 | year = 2008 | pmid = 18419129| pmc = }}, {{INIST|20325664}} 6. ^1 {{Cite journal | last1 = Hofmann | first1 = T. | last2 = Glabasnia | first2 = A. | last3 = Schwarz | first3 = B. | last4 = Wisman | first4 = K. N. | last5 = Gangwer | first5 = K. A. | last6 = Hagerman | first6 = A. E. | doi = 10.1021/jf062272c | title = Protein Binding and Astringent Taste of a Polymeric Procyanidin, 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranose, Castalagin, and Grandinin | journal = Journal of Agricultural and Food Chemistry | volume = 54 | issue = 25 | pages = 9503–9509 | year = 2006 | pmid = 17147439| pmc =2597504 }} 3 : Ellagitannins|Astringent flavors|Receptor tyrosine kinase inhibitors |
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