请输入您要查询的百科知识：

　

词条 GRAP
释义

  1. Interactions

  2. References

  3. Further reading

{{Infobox_gene}}GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene.[1][2][3]

This gene encodes a member of the GRB2/Sem5 (C. elegans homolog)/Drk (Drosophila homolog) family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.[3]

Interactions

GRAP has been shown to interact with Linker of activated T cells.[4][5]

References

1. ^{{cite journal | vauthors = Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J | title = Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway | journal = The Journal of Biological Chemistry | volume = 271 | issue = 21 | pages = 12129–32 | date = May 1996 | pmid = 8647802 | pmc = | doi = 10.1074/jbc.271.21.12129 }}
2. ^{{cite journal | vauthors = Trüb T, Frantz JD, Miyazaki M, Band H, Shoelson SE | title = The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling | journal = The Journal of Biological Chemistry | volume = 272 | issue = 2 | pages = 894–902 | date = Jan 1997 | pmid = 8995379 | pmc = | doi = 10.1074/jbc.272.2.894 }}
3. ^1 {{cite web | title = Entrez Gene: GRAP GRB2-related adaptor protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10750| accessdate = }}
4. ^{{cite journal | vauthors = Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE | title = LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation | journal = Cell | volume = 92 | issue = 1 | pages = 83–92 | date = Jan 1998 | pmid = 9489702 | doi = 10.1016/S0092-8674(00)80901-0 }}
5. ^{{cite journal | vauthors = Perez-Villar JJ, Whitney GS, Sitnick MT, Dunn RJ, Venkatesan S, O'Day K, Schieven GL, Lin TA, Kanner SB | title = Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav | journal = Biochemistry | volume = 41 | issue = 34 | pages = 10732–40 | date = Aug 2002 | pmid = 12186560 | doi = 10.1021/bi025554o }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE | title = Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins | journal = Oncogene | volume = 16 | issue = 7 | pages = 891–901 | date = Feb 1998 | pmid = 9484780 | doi = 10.1038/sj.onc.1201607 }}
  • {{cite journal | vauthors = Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE | title = LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation | journal = Cell | volume = 92 | issue = 1 | pages = 83–92 | date = Jan 1998 | pmid = 9489702 | doi = 10.1016/S0092-8674(00)80901-0 }}
  • {{cite journal | vauthors = Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O | title = Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor | journal = FEBS Letters | volume = 509 | issue = 2 | pages = 255–62 | date = Dec 2001 | pmid = 11741599 | doi = 10.1016/S0014-5793(01)03174-X }}
  • {{cite journal | vauthors = Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS | title = GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 36 | pages = 34641–53 | date = Sep 2003 | pmid = 12819203 | doi = 10.1074/jbc.M304594200 }}
  • {{cite journal | vauthors = Shiraiwa H, Takei M, Yoshikawa T, Azuma T, Kato M, Mitamura K, Ueki T, Kida A, Horie T, Seki N, Sawada S | title = Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome | journal = The Journal of International Medical Research | volume = 32 | issue = 3 | pages = 284–91 | year = 2004 | pmid = 15174222 | doi = 10.1177/147323000403200308 }}
{{refend}}{{gene-17-stub}}
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/11/13 22:10:54