“GRB14”的意思、由来-开放百科全书

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.^[2]

Interactions

GRB14 has been shown to interact with Epidermal growth factor receptor,^[3] Fibroblast growth factor receptor 1^[4] and TNKS2.^[5]

References

1. ^{{cite journal |vauthors=Baker E, Sutherland GR, Sutherland RL, Daly RJ | title = Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization | journal = Genomics | volume = 36 | issue = 1 | pages = 218–220 |date=February 1997 | pmid = 8812444 | pmc = | doi = 10.1006/geno.1996.0453 }}
2. ^¹{{cite web | title = Entrez Gene: GRB14 growth factor receptor-bound protein 14| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2888| accessdate = }}
3. ^{{cite journal |last=Daly |first=R J |authorlink= |author2=Sanderson G M |author3=Janes P W |author4=Sutherland R L |date=May 1996 |title=Cloning and characterization of GRB14, a novel member of the GRB7 gene family |journal=J. Biol. Chem. |volume=271 |issue=21 |pages=12502–12510 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8647858 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.271.21.12502 }}
4. ^{{cite journal |last=Reilly |first=J F |authorlink= |author2=Mickey G |author3=Maher P A |date=March 2000 |title=Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner |journal=J. Biol. Chem. |volume=275 |issue=11 |pages=7771–7778 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10713090 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.275.11.7771 }}
5. ^{{cite journal |last=Lyons |first=R J |authorlink= |author2=Deane R |author3=Lynch D K |author4=Ye Z S |author5=Sanderson G M |author6=Eyre H J |author7=Sutherland G R |author8=Daly R J |date=May 2001 |title=Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14 |journal=J. Biol. Chem. |volume=276 |issue=20 |pages=17172–17180 |publisher= |location = United States| issn = 0021-9258| pmid = 11278563 |doi = 10.1074/jbc.M009756200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}

Further reading

{{cite journal |vauthors=Han DC, Shen TL, Guan JL |title=The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions |journal=Oncogene |volume=20 |issue= 44 |pages= 6315–6321 |year= 2001 |pmid= 11607834 |doi= 10.1038/sj.onc.1204775 }}

{{cite journal |vauthors=Daly RJ, Sanderson GM, Janes PW, Sutherland RL |title=Cloning and characterization of GRB14, a novel member of the GRB7 gene family |journal=J. Biol. Chem. |volume=271 |issue= 21 |pages= 12502–12510 |year= 1996 |pmid= 8647858 |doi=10.1074/jbc.271.21.12502 }}

{{cite journal | author=Kasus-Jacobi A |title=Identification of the rat adapter Grb14 as an inhibitor of insulin actions |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 26026–26035 |year= 1998 |pmid= 9748281 |doi=10.1074/jbc.273.40.26026 |name-list-format=vanc| author2=Perdereau D | author3=Auzan C | display-authors=3 | last4=Clauser | first4=E | last5=Van Obberghen | first5=E | last6=Mauvais-Jarvis | first6=F | last7=Girard | first7=J | last8=Burnol | first8=AF }}

{{cite journal | author=Jones N |title=Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30896–30905 |year= 1999 |pmid= 10521483 |doi=10.1074/jbc.274.43.30896 |name-list-format=vanc| author2=Master Z | author3=Jones J | display-authors=3 | last4=Bouchard | first4=D | last5=Gunji | first5=Y | last6=Sasaki | first6=H | last7=Daly | first7=R | last8=Alitalo | first8=K | last9=Dumont | first9=DJ }}

{{cite journal |vauthors=Reilly JF, Mickey G, Maher PA |title=Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 7771–7778 |year= 2000 |pmid= 10713090 |doi=10.1074/jbc.275.11.7771 }}

{{cite journal | author=Hemming R |title=Human growth factor receptor bound 14 binds the activated insulin receptor and alters the insulin-stimulated tyrosine phosphorylation levels of multiple proteins |journal=Biochem. Cell Biol. |volume=79 |issue= 1 |pages= 21–32 |year= 2001 |pmid= 11235915 |doi=10.1139/bcb-79-1-21 |name-list-format=vanc| author2=Agatep R | author3=Badiani K | display-authors=3 | last4=Wyant | first4=Kerrie | last5=Arthur | first5=Gilbert | last6=Gietz | first6=R. Daniel | last7=Triggs-Raine | first7=Barbara }}

{{cite journal | author=Lyons RJ |title=Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14 |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17172–17180 |year= 2001 |pmid= 11278563 |doi= 10.1074/jbc.M009756200 |name-list-format=vanc| author2=Deane R | author3=Lynch DK | display-authors=3 | last4=Ye | first4=ZS | last5=Sanderson | first5=GM | last6=Eyre | first6=HJ | last7=Sutherland | first7=GR | last8=Daly | first8=RJ }}

{{cite journal | author=Béréziat V |title=Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14 |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4845–4852 |year= 2002 |pmid= 11726652 |doi= 10.1074/jbc.M106574200 |name-list-format=vanc| author2=Kasus-Jacobi A | author3=Perdereau D | display-authors=3 | last4=Cariou | first4=B | last5=Girard | first5=J | last6=Burnol | first6=AF }}

{{cite journal | author=Cariou B |title=The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta |journal=Mol. Cell. Biol. |volume=22 |issue= 20 |pages= 6959–6970 |year= 2002 |pmid= 12242277 |doi=10.1128/MCB.22.20.6959-6970.2002 | pmc=139806 |name-list-format=vanc| author2=Perdereau D | author3=Cailliau K | display-authors=3 | last4=Browaeys-Poly | first4=E. | last5=Bereziat | first5=V. | last6=Vasseur-Cognet | first6=M. | last7=Girard | first7=J. | last8=Burnol | first8=A.-F. }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M}}

{{cite journal |vauthors=King CC, Newton AC |title=The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1 |journal=J. Biol. Chem. |volume=279 |issue= 36 |pages= 37518–37527 |year= 2004 |pmid= 15210700 |doi= 10.1074/jbc.M405340200 }}

{{cite journal |vauthors=Scharf PJ, Witney J, Daly R, Lyons BA |title=Solution structure of the human Grb14-SH2 domain and comparison with the structures of the human Grb7-SH2/erbB2 peptide complex and human Grb10-SH2 domain |journal=Protein Sci. |volume=13 |issue= 9 |pages= 2541–2546 |year= 2005 |pmid= 15322292 |doi= 10.1110/ps.04884704 | pmc=2280013 }}

{{cite journal | author=Kairouz R |title=Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells |journal=J. Cell. Physiol. |volume=203 |issue= 1 |pages= 85–93 |year= 2005 |pmid= 15372466 |doi= 10.1002/jcp.20199 |name-list-format=vanc| author2=Parmar J | author3=Lyons RJ | display-authors=3 | last4=Swarbrick | first4=Alexander | last5=Musgrove | first5=Elizabeth A. | last6=Daly | first6=Roger J. }}

{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

{{cite journal | author=Depetris RS |title=Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14 |journal=Mol. Cell |volume=20 |issue= 2 |pages= 325–333 |year= 2006 |pmid= 16246733 |doi= 10.1016/j.molcel.2005.09.001 |name-list-format=vanc| author2=Hu J | author3=Gimpelevich I | display-authors=3 | last4=Holt | first4=Lowenna J. | last5=Daly | first5=Roger J. | last6=Hubbard | first6=Stevan R. }}

{{cite journal | author=Park JJ |title=GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle |journal=Physiol. Genomics |volume=27 |issue= 2 |pages= 114–121 |year= 2006 |pmid= 16849634 |doi= 10.1152/physiolgenomics.00045.2006 |name-list-format=vanc| author2=Berggren JR | author3=Hulver MW | display-authors=3 | last4=Houmard | first4=J. A | last5=Hoffman | first5=E. P. }}