| 释义 |
- Function
- Interactions
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Glutamate receptor, ionotropic kainate 5 is a protein that in humans is encoded by the GRIK5 gene.[1][2] Function This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.[2] Interactions GRIK5 has been shown to interact with DLG4[3][4] and GRIK2.[5][6] See also References 1. ^{{cite journal |vauthors=Szpirer C, Molne M, Antonacci R, Jenkins NA, Finelli P, Szpirer J, Riviere M, Rocchi M, Gilbert DJ, Copeland NG | title = The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 25 | pages = 11849–53 |date=January 1995 | pmid = 7527545 | pmc = 45333 | doi =10.1073/pnas.91.25.11849 |display-authors=etal}}
2. ^1 {{cite web | title = Entrez Gene: GRIK5 glutamate receptor, ionotropic, kainate 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2901| accessdate = }}
3. ^{{cite journal |vauthors=Mehta S, Wu H, Garner CC, Marshall J | title = Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97 | journal = J. Biol. Chem. | volume = 276 | issue = 19 | pages = 16092–9 |date=May 2001 | pmid = 11279111 | doi = 10.1074/jbc.M100643200 }}
4. ^{{cite journal |vauthors=Garcia EP, Mehta S, Blair LA, Wells DG, Shang J, Fukushima T, Fallon JR, Garner CC, Marshall J | title = SAP90 binds and clusters kainate receptors causing incomplete desensitization | journal = Neuron | volume = 21 | issue = 4 | pages = 727–39 |date=October 1998 | pmid = 9808460 | doi = 10.1016/S0896-6273(00)80590-5 }}
5. ^{{cite journal |vauthors=Wenthold RJ, Trumpy VA, Zhu WS, Petralia RS | title = Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies | journal = J. Biol. Chem. | volume = 269 | issue = 2 | pages = 1332–9 |date=January 1994 | pmid = 8288598 | doi = }}
6. ^{{cite journal |vauthors=Ripellino JA, Neve RL, Howe JR | title = Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum | journal = Neuroscience | volume = 82 | issue = 2 | pages = 485–97 |date=January 1998 | pmid = 9466455 | doi = 10.1016/S0306-4522(97)00296-0}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Kamboj RK, Schoepp DD, Nutt S, etal |title=Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit. |journal=Mol. Pharmacol. |volume=42 |issue= 1 |pages= 10–5 |year= 1992 |pmid= 1321949 |doi= }}
- {{cite journal |vauthors=Cauley K, Kukekov V, Young D |title=Kainate/AMPA receptors expressed on human fetal astrocytes in long-term culture. |journal=J. Neurosci. Res. |volume=47 |issue= 3 |pages= 311–21 |year= 1997 |pmid= 9039653 |doi=10.1002/(SICI)1097-4547(19970201)47:3<311::AID-JNR9>3.0.CO;2-L }}
- {{cite journal |vauthors=Porter RH, Eastwood SL, Harrison PJ |title=Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia. |journal=Brain Res. |volume=751 |issue= 2 |pages= 217–31 |year= 1997 |pmid= 9099808 |doi=10.1016/S0006-8993(96)01404-7 }}
- {{cite journal |vauthors=Ripellino JA, Neve RL, Howe JR |title=Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum. |journal=Neuroscience |volume=82 |issue= 2 |pages= 485–97 |year= 1998 |pmid= 9466455 |doi=10.1016/S0306-4522(97)00296-0 }}
- {{cite journal |vauthors=Garcia EP, Mehta S, Blair LA, etal |title=SAP90 binds and clusters kainate receptors causing incomplete desensitization. |journal=Neuron |volume=21 |issue= 4 |pages= 727–39 |year= 1998 |pmid= 9808460 |doi=10.1016/S0896-6273(00)80590-5 }}
- {{cite journal |vauthors=Mehta S, Wu H, Garner CC, Marshall J |title=Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97. |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 16092–9 |year= 2001 |pmid= 11279111 |doi= 10.1074/jbc.M100643200 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Kohda K, Kamiya Y, Matsuda S, etal |title=Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors. |journal=Brain Res. Mol. Brain Res. |volume=110 |issue= 1 |pages= 27–37 |year= 2003 |pmid= 12573530 |doi=10.1016/S0169-328X(02)00561-2 }}
- {{cite journal |vauthors=Hayes DM, Braud S, Hurtado DE, etal |title=Trafficking and surface expression of the glutamate receptor subunit, KA2. |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 1 |pages= 8–13 |year= 2003 |pmid= 14511640 |doi=10.1016/j.bbrc.2003.08.115 }}
- {{cite journal |vauthors=Kamm C, Leung J, Joseph S, etal |title=Refined linkage to the RDP/DYT12 locus on 19q13.2 and evaluation of GRIK5 as a candidate gene. |journal=Mov. Disord. |volume=19 |issue= 7 |pages= 845–7 |year= 2004 |pmid= 15254951 |doi= 10.1002/mds.20095 }}
{{refend}} External links - {{MeshName|GRIK5+protein,+human}}
{{NLM content}}{{Ligand-gated ion channels}}{{membrane-protein-stub}} 1 : Ionotropic glutamate receptors |