| 释义 |
- See also
- References
- Further reading
{{Infobox_gene}}Glutamate [NMDA] receptor subunit zeta-1 is a protein that in humans is encoded by the GRIN1 gene.[1][2]The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. The gene consists of 21 exons and is alternatively spliced, producing transcript variants differing in the C-terminus. Although the sequence of exon 5 is identical in human and rat, the alternative exon 5 splicing in rat has yet to be demonstrated in human. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits.[3] See alsoReferences1. ^{{cite journal |vauthors=Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH | title = Heteromeric NMDA receptors: molecular and functional distinction of subtypes | journal = Science | volume = 256 | issue = 5060 | pages = 1217–21 |date=Jun 1992 | pmid = 1350383 | pmc = | doi =10.1126/science.256.5060.1217 }}
2. ^{{cite web | title = Entrez Gene: GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2902| accessdate = }}
3. ^{{cite web | title = Entrez Gene: GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2902| accessdate = }}
Further reading{{refbegin |30em}}- {{cite journal |vauthors=Lin JW, Wyszynski M, Madhavan R, etal |title=Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1. |journal=J. Neurosci. |volume=18 |issue= 6 |pages= 2017–27 |year= 1998 |pmid= 9482789 |doi= }}
- {{cite journal |vauthors=Schröder HC, Perovic S, Kavsan V, etal |title=Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. |journal=Neurotoxicology |volume=19 |issue= 4–5 |pages= 683–8 |year= 1998 |pmid= 9745929 |doi= }}
- {{cite journal |vauthors=Adriani W, Felici A, Sargolini F, etal |title=N-methyl-D-aspartate and dopamine receptor involvement in the modulation of locomotor activity and memory processes |journal=Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale |volume=123 |issue= 1–2 |pages= 52–9 |year= 1999 |pmid= 9835392 |doi= 10.1007/s002210050544}}
- {{cite journal |vauthors=Dingledine R, Borges K, Bowie D, Traynelis SF |title=The glutamate receptor ion channels |journal=Pharmacol. Rev. |volume=51 |issue= 1 |pages= 7–61 |year= 1999 |pmid= 10049997 |doi= }}
- {{cite journal |vauthors=King JE, Eugenin EA, Buckner CM, Berman JW |title=HIV tat and neurotoxicity |journal=Microbes Infect. |volume=8 |issue= 5 |pages= 1347–57 |year= 2006 |pmid= 16697675 |doi= 10.1016/j.micinf.2005.11.014 }}
- {{cite journal |vauthors=Zimmer M, Fink TM, Franke Y, etal |title=Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1) |journal=Gene |volume=159 |issue= 2 |pages= 219–23 |year= 1995 |pmid= 7622053 |doi=10.1016/0378-1119(95)00044-7 }}
- {{cite journal |vauthors=Karp SJ, Masu M, Eki T, etal |title=Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor |journal=J. Biol. Chem. |volume=268 |issue= 5 |pages= 3728–33 |year= 1993 |pmid= 7679115 |doi= }}
- {{cite journal |vauthors=Younkin DP, Tang CM, Hardy M, etal |title=Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 6 |pages= 2174–8 |year= 1993 |pmid= 7681588 |doi=10.1073/pnas.90.6.2174 | pmc=46048 }}
- {{cite journal |vauthors=Planells-Cases R, Sun W, Ferrer-Montiel AV, Montal M |title=Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 11 |pages= 5057–61 |year= 1993 |pmid= 7685113 |doi=10.1073/pnas.90.11.5057 | pmc=46653 }}
- {{cite journal |vauthors=Magnuson DS, Knudsen BE, Geiger JD, etal |title=Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity |journal=Ann. Neurol. |volume=37 |issue= 3 |pages= 373–80 |year= 1995 |pmid= 7695237 |doi= 10.1002/ana.410370314 }}
- {{cite journal |vauthors=Foldes RL, Rampersad V, Kamboj RK |title=Cloning and sequence analysis of additional splice variants encoding human N-methyl-D-aspartate receptor (hNR1) subunits |journal=Gene |volume=147 |issue= 2 |pages= 303–4 |year= 1994 |pmid= 7926821 |doi=10.1016/0378-1119(94)90089-2 }}
- {{cite journal |vauthors=Sheng M, Cummings J, Roldan LA, etal |title=Changing subunit composition of heteromeric NMDA receptors during development of rat cortex |journal=Nature |volume=368 |issue= 6467 |pages= 144–7 |year= 1994 |pmid= 8139656 |doi= 10.1038/368144a0 }}
- {{cite journal |vauthors=Tingley WG, Roche KW, Thompson AK, Huganir RL |title=Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain |journal=Nature |volume=364 |issue= 6432 |pages= 70–3 |year= 1993 |pmid= 8316301 |doi= 10.1038/364070a0 }}
- {{cite journal |vauthors=Foldes RL, Rampersad V, Kamboj RK |title=Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing |journal=Gene |volume=131 |issue= 2 |pages= 293–8 |year= 1993 |pmid= 8406025 |doi=10.1016/0378-1119(93)90309-Q }}
- {{cite journal |vauthors=Collins C, Duff C, Duncan AM, etal |title=Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively |journal=Genomics |volume=17 |issue= 1 |pages= 237–9 |year= 1993 |pmid= 8406459 |doi= 10.1006/geno.1993.1311 }}
- {{cite journal |vauthors=Lannuzel A, Lledo PM, Lamghitnia HO, etal |title=HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons |journal=Eur. J. Neurosci. |volume=7 |issue= 11 |pages= 2285–93 |year= 1996 |pmid= 8563977 |doi=10.1111/j.1460-9568.1995.tb00649.x }}
- {{cite journal |vauthors=Corasaniti MT, Melino G, Navarra M, etal |title=Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase |journal=Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration |volume=4 |issue= 3 |pages= 315–21 |year= 1996 |pmid= 8581564 |doi= 10.1016/1055-8330(95)90021-7}}
- {{cite journal |vauthors=Ehlers MD, Zhang S, Bernhadt JP, Huganir RL |title=Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit |journal=Cell |volume=84 |issue= 5 |pages= 745–55 |year= 1996 |pmid= 8625412 |doi=10.1016/S0092-8674(00)81052-1 }}
- {{cite journal |vauthors=Pittaluga A, Pattarini R, Severi P, Raiteri M |title=Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120 |journal=AIDS |volume=10 |issue= 5 |pages= 463–8 |year= 1996 |pmid= 8724036 |doi=10.1097/00002030-199605000-00003 }}
{{refend}}{{Ligand-gated ion channels}}{{transmembranereceptor-stub}} 2 : Ionotropic glutamate receptors|Ion channels |