请输入您要查询的百科知识：

　

词条 GRIN2A
释义

  1. Function

  2. Associations

  3. Interactions

  4. See also

  5. References

  6. Further reading

{{Infobox_gene}}Glutamate [NMDA] receptor subunit epsilon-1 is a protein that in humans is encoded by the GRIN2A gene.[1]

Function

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).[2]

Associations

Variants of the gene are associated with the protective effect of coffee on Parkinson's disease.[3][4]

Mutations in GRIN2A are associated to refractory epilepsy.[5]

Whole exome/genome sequencing has led to the discovery of an association between mutations in GRIN2A and a wide variety of neurological diseases, including epilepsy, intellectual disability, autism spectrum disorders, developmental delay, and schizophrenia.[6]

Interactions

GRIN2A has been shown to interact with:

  • DLG1[7]
  • DLG3[8][9]
  • DLG4[8][9][12][10][11]
  • FYN[12][13][14][15]
  • Interleukin 16[16]
  • PTK2B[17][18]
  • Src[13][15]

See also

  • Glutamate receptor
  • NMDA receptor
{{Clear}}

References

1. ^{{cite journal | vauthors = Kalsi G, Whiting P, Bourdelles BL, Callen D, Barnard EA, Gurling H | title = Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels | journal = Genomics | volume = 47 | issue = 3 | pages = 423–5 | date = April 1998 | pmid = 9480759 | pmc = | doi = 10.1006/geno.1997.5132 }}
2. ^{{cite web | title = Entrez Gene: GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2903| accessdate = }}
3. ^{{cite journal | vauthors = Hamza TH, Chen H, Hill-Burns EM, Rhodes SL, Montimurro J, Kay DM, Tenesa A, Kusel VI, Sheehan P, Eaaswarkhanth M, Yearout D, Samii A, Roberts JW, Agarwal P, Bordelon Y, Park Y, Wang L, Gao J, Vance JM, Kendler KS, Bacanu SA, Scott WK, Ritz B, Nutt J, Factor SA, Zabetian CP, Payami H | title = Genome-wide gene-environment study identifies glutamate receptor gene GRIN2A as a Parkinson's disease modifier gene via interaction with coffee | journal = PLoS Genet. | volume = 7 | issue = 8 | pages = e1002237 | date = August 2011 | pmid = 21876681 | doi = 10.1371/journal.pgen.1002237 | pmc=3158052}}
4. ^{{cite journal | vauthors = Yamada-Fowler N, Fredrikson M, Söderkvist P | title = Caffeine interaction with glutamate receptor gene GRIN2A: Parkinson's disease in Swedish population | journal = PLoS ONE | volume = 9 | issue = 6 | pages = e99294 | date = June 2014 | pmid = 24915238 | doi = 10.1371/journal.pone.0099294 | pmc=4051678}}
5. ^{{cite journal | vauthors = Venkateswaran S, Myers KA, Smith AC, Beaulieu CL, Schwartzentruber JA, Majewski J, Bulman D, Boycott KM, Dyment DA | title = Whole-exome sequencing in an individual with severe global developmental delay and intractable epilepsy identifies a novel, de novo GRIN2A mutation | journal = Epilepsia | volume = 55 | issue = 7 | pages = e75-9 | year = 2014 | pmid = 24903190 | doi = 10.1111/epi.12663 }}
6. ^{{cite journal|last1=Yuan|first1=H.|last2=Low|first2=C.-M.|last3=Moody|first3=O. A.|last4=Jenkins|first4=A.|last5=Traynelis|first5=S. F.|title=Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases|journal=Molecular Pharmacology|volume=88|issue=1|year=2015|pages=203–217|issn=1521-0111|doi=10.1124/mol.115.097998|pmc=4468639}}
7. ^{{cite journal | vauthors = Gardoni F, Mauceri D, Fiorentini C, Bellone C, Missale C, Cattabeni F, Di Luca M | title = CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction | journal = J. Biol. Chem. | volume = 278 | issue = 45 | pages = 44745–52 | date = November 2003 | pmid = 12933808 | doi = 10.1074/jbc.M303576200 }}
8. ^1 {{cite journal | vauthors = Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, Takai Y, Rosahl TW, Südhof TC | title = Binding of neuroligins to PSD-95 | journal = Science | volume = 277 | issue = 5331 | pages = 1511–5 | date = September 1997 | pmid = 9278515 | doi = 10.1126/science.277.5331.1511}}
9. ^1 {{cite journal | vauthors = Lim IA, Hall DD, Hell JW | title = Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102 | journal = J. Biol. Chem. | volume = 277 | issue = 24 | pages = 21697–711 | date = June 2002 | pmid = 11937501 | doi = 10.1074/jbc.M112339200 }}
10. ^{{cite journal | vauthors = Satoh K, Yanai H, Senda T, Kohu K, Nakamura T, Okumura N, Matsumine A, Kobayashi S, Toyoshima K, Akiyama T | title = DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95 | journal = Genes Cells | volume = 2 | issue = 6 | pages = 415–24 | date = June 1997 | pmid = 9286858 | doi = 10.1046/j.1365-2443.1997.1310329.x}}
11. ^{{cite journal | vauthors = Sans N, Petralia RS, Wang YX, Blahos J, Hell JW, Wenthold RJ | title = A developmental change in NMDA receptor-associated proteins at hippocampal synapses | journal = J. Neurosci. | volume = 20 | issue = 3 | pages = 1260–71 | date = February 2000 | pmid = 10648730 | doi = }}
12. ^1 {{cite journal | vauthors = Hou XY, Zhang GY, Yan JZ, Chen M, Liu Y | title = Activation of NMDA receptors and L-type voltage-gated calcium channels mediates enhanced formation of Fyn-PSD95-NR2A complex after transient brain ischemia | journal = Brain Res. | volume = 955 | issue = 1-2 | pages = 123–32 | date = November 2002 | pmid = 12419528 | doi = 10.1016/s0006-8993(02)03376-0}}
13. ^1 {{cite journal | vauthors = Ma J, Zhang GY | title = Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia | journal = Neurosci. Lett. | volume = 348 | issue = 3 | pages = 185–9 | date = September 2003 | pmid = 12932824 | doi = 10.1016/s0304-3940(03)00784-5}}
14. ^{{cite journal | vauthors = Tezuka T, Umemori H, Akiyama T, Nakanishi S, Yamamoto T | title = PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 2 | pages = 435–40 | date = January 1999 | pmid = 9892651 | pmc = 15154 | doi = 10.1073/pnas.96.2.435}}
15. ^1 {{cite journal | vauthors = Takagi N, Cheung HH, Bissoon N, Teves L, Wallace MC, Gurd JW | title = The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains | journal = J. Cereb. Blood Flow Metab. | volume = 19 | issue = 8 | pages = 880–8 | date = August 1999 | pmid = 10458595 | doi = 10.1097/00004647-199908000-00007 }}
16. ^{{cite journal | vauthors = Kurschner C, Yuzaki M | title = Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein | journal = J. Neurosci. | volume = 19 | issue = 18 | pages = 7770–80 | date = September 1999 | pmid = 10479680 | doi = }}
17. ^{{cite journal | vauthors = Seabold GK, Burette A, Lim IA, Weinberg RJ, Hell JW | title = Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102 | journal = J. Biol. Chem. | volume = 278 | issue = 17 | pages = 15040–8 | date = April 2003 | pmid = 12576483 | doi = 10.1074/jbc.M212825200 }}
18. ^{{cite journal | vauthors = Liu Y, Zhang G, Gao C, Hou X | title = NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion | journal = Brain Res. | volume = 909 | issue = 1-2 | pages = 51–8 | date = August 2001 | pmid = 11478920 | doi = 10.1016/s0006-8993(01)02619-1}}

Further reading

{{refbegin|35em}}
  • {{cite journal | vauthors = Schröder HC, Perovic S, Kavsan V, Ushijima H, Müller WE | title = Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death | journal = Neurotoxicology | volume = 19 | issue = 4-5 | pages = 683–8 | year = 1998 | pmid = 9745929 | doi = }}
  • {{cite journal | vauthors = King JE, Eugenin EA, Buckner CM, Berman JW | title = HIV tat and neurotoxicity | journal = Microbes Infect. | volume = 8 | issue = 5 | pages = 1347–57 | year = 2006 | pmid = 16697675 | doi = 10.1016/j.micinf.2005.11.014 }}
  • {{cite journal | vauthors = Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH | title = Heteromeric NMDA receptors: molecular and functional distinction of subtypes | journal = Science | volume = 256 | issue = 5060 | pages = 1217–21 | year = 1992 | pmid = 1350383 | doi = 10.1126/science.256.5060.1217 }}
  • {{cite journal | vauthors = Kornau HC, Schenker LT, Kennedy MB, Seeburg PH | title = Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95 | journal = Science | volume = 269 | issue = 5231 | pages = 1737–40 | year = 1995 | pmid = 7569905 | doi = 10.1126/science.7569905 }}
  • {{cite journal | vauthors = Magnuson DS, Knudsen BE, Geiger JD, Brownstone RM, Nath A | title = Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity | journal = Ann. Neurol. | volume = 37 | issue = 3 | pages = 373–80 | year = 1995 | pmid = 7695237 | doi = 10.1002/ana.410370314 }}
  • {{cite journal | vauthors = Sakimura K, Kutsuwada T, Ito I, Manabe T, Takayama C, Kushiya E, Yagi T, Aizawa S, Inoue Y, Sugiyama H | title = Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit | journal = Nature | volume = 373 | issue = 6510 | pages = 151–5 | year = 1995 | pmid = 7816096 | doi = 10.1038/373151a0 }}
  • {{cite journal | vauthors = Foldes RL, Adams SL, Fantaske RP, Kamboj RK | title = Human N-methyl-D-aspartate receptor modulatory subunit hNR2A: cloning and sequencing of the cDNA and primary structure of the protein | journal = Biochim. Biophys. Acta | volume = 1223 | issue = 1 | pages = 155–9 | year = 1994 | pmid = 8061049 | doi = 10.1016/0167-4889(94)90086-8 }}
  • {{cite journal | vauthors = Sheng M, Cummings J, Roldan LA, Jan YN, Jan LY | title = Changing subunit composition of heteromeric NMDA receptors during development of rat cortex | journal = Nature | volume = 368 | issue = 6467 | pages = 144–7 | year = 1994 | pmid = 8139656 | doi = 10.1038/368144a0 }}
  • {{cite journal | vauthors = Roche KW, Raymond LA, Blackstone C, Huganir RL | title = Transmembrane topology of the glutamate receptor subunit GluR6 | journal = J. Biol. Chem. | volume = 269 | issue = 16 | pages = 11679–82 | year = 1994 | pmid = 8163463 | doi = }}
  • {{cite journal | vauthors = Takano H, Onodera O, Tanaka H, Mori H, Sakimura K, Hori T, Kobayashi H, Mishina M, Tsuji S | title = Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel | journal = Biochem. Biophys. Res. Commun. | volume = 197 | issue = 2 | pages = 922–6 | year = 1993 | pmid = 8267632 | doi = 10.1006/bbrc.1993.2567 }}
  • {{cite journal | vauthors = Lannuzel A, Lledo PM, Lamghitnia HO, Vincent JD, Tardieu M | title = HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons | journal = Eur. J. Neurosci. | volume = 7 | issue = 11 | pages = 2285–93 | year = 1995 | pmid = 8563977 | doi = 10.1111/j.1460-9568.1995.tb00649.x }}
  • {{cite journal | vauthors = Corasaniti MT, Melino G, Navarra M, Garaci E, Finazzi-Agrò A, Nisticò G | title = Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase | journal = Neurodegeneration | volume = 4 | issue = 3 | pages = 315–21 | year = 1995 | pmid = 8581564 | doi = 10.1016/1055-8330(95)90021-7 }}
  • {{cite journal | vauthors = Niethammer M, Kim E, Sheng M | title = Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases | journal = J. Neurosci. | volume = 16 | issue = 7 | pages = 2157–63 | year = 1996 | pmid = 8601796 | doi = }}
  • {{cite journal | vauthors = Pittaluga A, Pattarini R, Severi P, Raiteri M | title = Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120 | journal = AIDS | volume = 10 | issue = 5 | pages = 463–8 | year = 1996 | pmid = 8724036 | doi = 10.1097/00002030-199605000-00003 }}
  • {{cite journal | vauthors = Hess SD, Daggett LP, Crona J, Deal C, Lu CC, Urrutia A, Chavez-Noriega L, Ellis SB, Johnson EC, Veliçelebi G | title = Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors | journal = J. Pharmacol. Exp. Ther. | volume = 278 | issue = 2 | pages = 808–16 | year = 1996 | pmid = 8768735 | doi = }}
  • {{cite journal | vauthors = Wu P, Price P, Du B, Hatch WC, Terwilliger EF | title = Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons | journal = NeuroReport | volume = 7 | issue = 5 | pages = 1045–9 | year = 1996 | pmid = 8804048 | doi = 10.1097/00001756-199604100-00018 }}
  • {{cite journal | vauthors = Bennett BA, Rusyniak DE, Hollingsworth CK | title = HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures | journal = Brain Res. | volume = 705 | issue = 1-2 | pages = 168–76 | year = 1995 | pmid = 8821747 | doi = 10.1016/0006-8993(95)01166-8 }}
  • {{cite journal | vauthors = Toggas SM, Masliah E, Mucke L | title = Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine | journal = Brain Res. | volume = 706 | issue = 2 | pages = 303–7 | year = 1996 | pmid = 8822372 | doi = 10.1016/0006-8993(95)01197-8 }}
  • {{cite journal | vauthors = Dreyer EB, Lipton SA | title = The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid | journal = Eur. J. Neurosci. | volume = 7 | issue = 12 | pages = 2502–7 | year = 1995 | pmid = 8845955 | doi = 10.1111/j.1460-9568.1995.tb01048.x }}
  • {{cite journal | vauthors = Raber J, Toggas SM, Lee S, Bloom FE, Epstein CJ, Mucke L | title = Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase | journal = Virology | volume = 226 | issue = 2 | pages = 362–73 | year = 1996 | pmid = 8955056 | doi = 10.1006/viro.1996.0664 }}
{{refend}}{{PDB Gallery|geneid=2903}}{{Ligand-gated ion channels}}{{NLM content}}

1 : Ionotropic glutamate receptors
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/11/17 11:07:13