1. Function

2. Interactions

3. See also

4. References

5. Further reading

6. External links

Function

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).^[2]

Interactions

GRIN2C has been shown to interact with DLG4^[3] and DLG3.^[3]

See also

• Glutamate receptor
• NMDA receptor

References

Further reading

• {{cite journal | vauthors = Schröder HC, Perovic S, Kavsan V, Ushijima H, Müller WE | title = Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death | journal = Neurotoxicology | volume = 19 | issue = 4-5 | pages = 683–8 | year = 1998 | pmid = 9745929 | doi = }}
• {{cite journal | vauthors = King JE, Eugenin EA, Buckner CM, Berman JW | title = HIV tat and neurotoxicity | journal = Microbes Infect. | volume = 8 | issue = 5 | pages = 1347–57 | year = 2006 | pmid = 16697675 | doi = 10.1016/j.micinf.2005.11.014 }}
• {{cite journal | vauthors = Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH | title = Heteromeric NMDA receptors: molecular and functional distinction of subtypes | journal = Science | volume = 256 | issue = 5060 | pages = 1217–21 | year = 1992 | pmid = 1350383 | doi = 10.1126/science.256.5060.1217 }}
• {{cite journal | vauthors = Kornau HC, Schenker LT, Kennedy MB, Seeburg PH | title = Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95 | journal = Science | volume = 269 | issue = 5231 | pages = 1737–40 | year = 1995 | pmid = 7569905 | doi = 10.1126/science.7569905 }}
• {{cite journal | vauthors = Magnuson DS, Knudsen BE, Geiger JD, Brownstone RM, Nath A | title = Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity | journal = Ann. Neurol. | volume = 37 | issue = 3 | pages = 373–80 | year = 1995 | pmid = 7695237 | doi = 10.1002/ana.410370314 }}
• {{cite journal | vauthors = Takano H, Onodera O, Tanaka H, Mori H, Sakimura K, Hori T, Kobayashi H, Mishina M, Tsuji S | title = Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel | journal = Biochem. Biophys. Res. Commun. | volume = 197 | issue = 2 | pages = 922–6 | year = 1993 | pmid = 8267632 | doi = 10.1006/bbrc.1993.2567 }}
• {{cite journal | vauthors = Lannuzel A, Lledo PM, Lamghitnia HO, Vincent JD, Tardieu M | title = HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons | journal = Eur. J. Neurosci. | volume = 7 | issue = 11 | pages = 2285–93 | year = 1995 | pmid = 8563977 | doi = 10.1111/j.1460-9568.1995.tb00649.x }}
• {{cite journal | vauthors = Corasaniti MT, Melino G, Navarra M, Garaci E, Finazzi-Agrò A, Nisticò G | title = Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase | journal = Neurodegeneration | volume = 4 | issue = 3 | pages = 315–21 | year = 1995 | pmid = 8581564 | doi = 10.1016/1055-8330(95)90021-7 }}
• {{cite journal | vauthors = Pittaluga A, Pattarini R, Severi P, Raiteri M | title = Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120 | journal = AIDS | volume = 10 | issue = 5 | pages = 463–8 | year = 1996 | pmid = 8724036 | doi = 10.1097/00002030-199605000-00003 }}
• {{cite journal | vauthors = Wu P, Price P, Du B, Hatch WC, Terwilliger EF | title = Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons | journal = NeuroReport | volume = 7 | issue = 5 | pages = 1045–9 | year = 1996 | pmid = 8804048 | doi = 10.1097/00001756-199604100-00018 }}
• {{cite journal | vauthors = Bennett BA, Rusyniak DE, Hollingsworth CK | title = HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures | journal = Brain Res. | volume = 705 | issue = 1-2 | pages = 168–76 | year = 1995 | pmid = 8821747 | doi = 10.1016/0006-8993(95)01166-8 }}
• {{cite journal | vauthors = Toggas SM, Masliah E, Mucke L | title = Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine | journal = Brain Res. | volume = 706 | issue = 2 | pages = 303–7 | year = 1996 | pmid = 8822372 | doi = 10.1016/0006-8993(95)01197-8 }}
• {{cite journal | vauthors = Dreyer EB, Lipton SA | title = The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid | journal = Eur. J. Neurosci. | volume = 7 | issue = 12 | pages = 2502–7 | year = 1995 | pmid = 8845955 | doi = 10.1111/j.1460-9568.1995.tb01048.x }}
• {{cite journal | vauthors = Raber J, Toggas SM, Lee S, Bloom FE, Epstein CJ, Mucke L | title = Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase | journal = Virology | volume = 226 | issue = 2 | pages = 362–73 | year = 1996 | pmid = 8955056 | doi = 10.1006/viro.1996.0664 }}
• {{cite journal | vauthors = Lin YJ, Bovetto S, Carver JM, Giordano T | title = Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery | journal = Brain Res. Mol. Brain Res. | volume = 43 | issue = 1-2 | pages = 57–64 | year = 1996 | pmid = 9037519 | doi = 10.1016/S0169-328X(96)00146-5 }}
• {{cite journal | vauthors = Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ |authorlink4=D. James Surmeier| title = CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins | journal = Mol. Cell. Neurosci. | volume = 11 | issue = 3 | pages = 161–72 | year = 1998 | pmid = 9647694 | doi = 10.1006/mcne.1998.0679 }}
• {{cite journal | vauthors = New DR, Maggirwar SB, Epstein LG, Dewhurst S, Gelbard HA | title = HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism | journal = J. Biol. Chem. | volume = 273 | issue = 28 | pages = 17852–8 | year = 1998 | pmid = 9651389 | doi = 10.1074/jbc.273.28.17852 }}
• {{cite journal | vauthors = Daggett LP, Johnson EC, Varney MA, Lin FF, Hess SD, Deal CR, Jachec C, Lu CC, Kerner JA, Landwehrmeyer GB, Standaert DG, Young AB, Harpold MM, Veliçelebi G | title = The human N-methyl-D-aspartate receptor 2C subunit: genomic analysis, distribution in human brain, and functional expression | journal = J. Neurochem. | volume = 71 | issue = 5 | pages = 1953–68 | year = 1998 | pmid = 9798920 | doi = 10.1046/j.1471-4159.1998.71051953.x }}

External links

• {{MeshName|GRIN2C+protein,+human}}

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