| 释义 |
- Function
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Glutamate [NMDA] receptor subunit 3A is a protein that in humans is encoded by the GRIN3A gene.[1] Function This gene encodes a subunit of the N-methyl-D-aspartate (NMDAR) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity.[1] See alsoReferences1. ^1 {{cite web | title = Entrez Gene: GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116443| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Schröder HC, Perovic S, Kavsan V, Ushijima H, Müller WE | title = Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. | journal = Neurotoxicology | volume = 19 | issue = 4–5 | pages = 683–8 | year = 1998 | pmid = 9745929 | doi = }}
- {{cite journal |vauthors=Eriksson M, Nilsson A, Samuelsson H, Samuelsson EB, Mo L, Akesson E, Benedikz E, Sundström E | title = On the role of NR3A in human NMDA receptors. | journal = Physiol. Behav. | volume = 92 | issue = 1–2 | pages = 54–9 | year = 2007 | pmid = 17617428 | doi = 10.1016/j.physbeh.2007.05.026 }}
- {{cite journal |vauthors=Kornau HC, Schenker LT, Kennedy MB, Seeburg PH | title = Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. | journal = Science | volume = 269 | issue = 5231 | pages = 1737–40 | year = 1995 | pmid = 7569905 | doi = 10.1126/science.7569905 | bibcode = 1995Sci...269.1737K }}
- {{cite journal |vauthors=Magnuson DS, Knudsen BE, Geiger JD, Brownstone RM, Nath A | title = Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity. | journal = Ann. Neurol. | volume = 37 | issue = 3 | pages = 373–80 | year = 1995 | pmid = 7695237 | doi = 10.1002/ana.410370314 }}
- {{cite journal |vauthors=Lannuzel A, Lledo PM, Lamghitnia HO, Vincent JD, Tardieu M | title = HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons. | journal = Eur. J. Neurosci. | volume = 7 | issue = 11 | pages = 2285–93 | year = 1996 | pmid = 8563977 | doi = 10.1111/j.1460-9568.1995.tb00649.x }}
- {{cite journal |vauthors=Corasaniti MT, Melino G, Navarra M, Garaci E, Finazzi-Agrò A, Nisticò G | title = Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase. | journal = Neurodegeneration | volume = 4 | issue = 3 | pages = 315–21 | year = 1996 | pmid = 8581564 | doi = 10.1016/1055-8330(95)90021-7 }}
- {{cite journal |vauthors=Pittaluga A, Pattarini R, Severi P, Raiteri M | title = Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120. | journal = AIDS | volume = 10 | issue = 5 | pages = 463–8 | year = 1996 | pmid = 8724036 | doi = 10.1097/00002030-199605000-00003 }}
- {{cite journal |vauthors=Wu P, Price P, Du B, Hatch WC, Terwilliger EF | title = Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons. | journal = NeuroReport | volume = 7 | issue = 5 | pages = 1045–9 | year = 1996 | pmid = 8804048 | doi = 10.1097/00001756-199604100-00018 }}
- {{cite journal |vauthors=Bennett BA, Rusyniak DE, Hollingsworth CK | title = HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures. | journal = Brain Res. | volume = 705 | issue = 1–2 | pages = 168–76 | year = 1996 | pmid = 8821747 | doi = 10.1016/0006-8993(95)01166-8 }}
- {{cite journal |vauthors=Toggas SM, Masliah E, Mucke L | title = Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine. | journal = Brain Res. | volume = 706 | issue = 2 | pages = 303–7 | year = 1996 | pmid = 8822372 | doi = 10.1016/0006-8993(95)01197-8 }}
- {{cite journal |vauthors=Dreyer EB, Lipton SA | title = The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid. | journal = Eur. J. Neurosci. | volume = 7 | issue = 12 | pages = 2502–7 | year = 1996 | pmid = 8845955 | doi = 10.1111/j.1460-9568.1995.tb01048.x }}
- {{cite journal |vauthors=Raber J, Toggas SM, Lee S, Bloom FE, Epstein CJ, Mucke L | title = Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase. | journal = Virology | volume = 226 | issue = 2 | pages = 362–73 | year = 1997 | pmid = 8955056 | doi = 10.1006/viro.1996.0664 }}
- {{cite journal |vauthors=Das S, Sasaki YF, Rothe T, Premkumar LS, Takasu M, Crandall JE, Dikkes P, Conner DA, Rayudu PV, Cheung W, Chen HS, Lipton SA, Nakanishi N | title = Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. | journal = Nature | volume = 393 | issue = 6683 | pages = 377–81 | year = 1998 | pmid = 9620802 | doi = 10.1038/30748 | bibcode = 1998Natur.393..377D }}
- {{cite journal |vauthors=New DR, Maggirwar SB, Epstein LG, Dewhurst S, Gelbard HA | title = HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism. | journal = J. Biol. Chem. | volume = 273 | issue = 28 | pages = 17852–8 | year = 1998 | pmid = 9651389 | doi = 10.1074/jbc.273.28.17852 }}
- {{cite journal |vauthors=Wang P, Barks JD, Silverstein FS | title = Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats. | journal = Neuroscience | volume = 88 | issue = 2 | pages = 585–97 | year = 1999 | pmid = 10197777 | doi = 10.1016/S0306-4522(98)00242-5 }}
- {{cite journal |vauthors=Howard SA, Nakayama AY, Brooke SM, Sapolsky RM | title = Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures. | journal = Exp. Neurol. | volume = 158 | issue = 1 | pages = 164–70 | year = 1999 | pmid = 10448428 | doi = 10.1006/exnr.1999.7080 }}
- {{cite journal |vauthors=Xin KQ, Hamajima K, Hattori S, Cao XR, Kawamoto S, Okuda K | title = Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system. | journal = AIDS Res. Hum. Retroviruses | volume = 15 | issue = 16 | pages = 1461–7 | year = 1999 | pmid = 10555109 | doi = 10.1089/088922299309973 }}
- {{cite journal |vauthors=Perez-Otano I, Schulteis CT, Contractor A, Lipton SA, Trimmer JS, Sucher NJ, Heinemann SF | title = Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors. | journal = J. Neurosci. | volume = 21 | issue = 4 | pages = 1228–37 | year = 2001 | pmid = 11160393 | doi = 10.1523/JNEUROSCI.21-04-01228.2001}}
- {{cite journal |vauthors=Haughey NJ, Nath A, Mattson MP, Slevin JT, Geiger JD | title = HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. | journal = J. Neurochem. | volume = 78 | issue = 3 | pages = 457–67 | year = 2001 | pmid = 11483648 | doi = 10.1046/j.1471-4159.2001.00396.x }}
{{refend}} External links - {{MeshName|GRIN3A+protein,+human}}
{{Ligand-gated ion channels}}{{gene-9-stub}} 1 : Ionotropic glutamate receptors |