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词条 GRK4
释义

  1. References

  2. Further reading

{{Infobox_gene}}G protein-coupled receptor kinase 4 is an enzyme that in humans is encoded by the GRK4 gene.[1][2]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.[2]

References

1. ^{{cite journal |vauthors=Ambrose C, James M, Barnes G, Lin C, Bates G, Altherr M, Duyao M, Groot N, Church D, Wasmuth JJ | title = A novel G protein-coupled receptor kinase gene cloned from 4p16.3 | journal = Hum Mol Genet | volume = 1 | issue = 9 | pages = 697–703 |date=Jun 1993 | pmid = 1338872 | pmc = | doi =10.1093/hmg/1.9.697 |display-authors=etal}}
2. ^1 {{cite web | title = Entrez Gene: GRK4 G protein-coupled receptor kinase 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2868| accessdate = }}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
  • {{cite journal |vauthors=Sallese M, Lombardi MS, De Blasi A |title=Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning |journal=Biochem. Biophys. Res. Commun. |volume=199 |issue= 2 |pages= 848–54 |year= 1994 |pmid= 8135832 |doi=10.1006/bbrc.1994.1306 }}
  • {{cite journal |vauthors=Premont RT, Macrae AD, Stoffel RH, etal |title=Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants |journal=J. Biol. Chem. |volume=271 |issue= 11 |pages= 6403–10 |year= 1996 |pmid= 8626439 |doi=10.1074/jbc.271.11.6403 }}
  • {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
  • {{cite journal |vauthors=Sallese M, Mariggiò S, Collodel G, etal |title=G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells |journal=J. Biol. Chem. |volume=272 |issue= 15 |pages= 10188–95 |year= 1997 |pmid= 9092566 |doi=10.1074/jbc.272.15.10188 }}
  • {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal |vauthors=Lazari MF, Liu X, Nakamura K, etal |title=Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor |journal=Mol. Endocrinol. |volume=13 |issue= 6 |pages= 866–78 |year= 1999 |pmid= 10379886 |doi=10.1210/me.13.6.866 }}
  • {{cite journal |vauthors=Blaukat A, Pizard A, Breit A, etal |title=Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 40431–40 |year= 2001 |pmid= 11517230 |doi= 10.1074/jbc.M107024200 }}
  • {{cite journal |vauthors=Watanabe H, Xu J, Bengra C, etal |title=Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4 |journal=Kidney Int. |volume=62 |issue= 3 |pages= 790–8 |year= 2003 |pmid= 12164861 |doi= 10.1046/j.1523-1755.2002.00525.x }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
  • {{cite journal |vauthors=Perroy J, Adam L, Qanbar R, etal |title=Phosphorylation-independent desensitization of GABAB receptor by GRK4 |journal=EMBO J. |volume=22 |issue= 15 |pages= 3816–24 |year= 2003 |pmid= 12881416 |doi= 10.1093/emboj/cdg383 | pmc=169056 }}
  • {{cite journal |vauthors=Speirs HJ, Katyk K, Kumar NN, etal |title=Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension |journal=J. Hypertens. |volume=22 |issue= 5 |pages= 931–6 |year= 2004 |pmid= 15097232 |doi=10.1097/00004872-200405000-00014 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
  • {{cite journal |vauthors=Rankin ML, Marinec PS, Cabrera DM, etal |title=The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4 |journal=Mol. Pharmacol. |volume=69 |issue= 3 |pages= 759–69 |year= 2006 |pmid= 16338988 |doi= 10.1124/mol.105.019901 }}
  • {{cite journal |vauthors=Zhu H, Lu Y, Wang X, etal |title=The G protein-coupled receptor kinase 4 gene affects blood pressure in young normotensive twins |journal=Am. J. Hypertens. |volume=19 |issue= 1 |pages= 61–6 |year= 2006 |pmid= 16461192 |doi= 10.1016/j.amjhyper.2005.07.007 }}
  • {{cite journal |vauthors=Zhu H, Lu Y, Wang X, etal |title=The G protein-coupled receptor kinase 4 gene modulates stress-induced sodium excretion in black normotensive adolescents |journal=Pediatr. Res. |volume=60 |issue= 4 |pages= 440–2 |year= 2006 |pmid= 16940246 |doi= 10.1203/01.pdr.0000238250.64591.44 }}
  • {{cite journal |vauthors=Wang Y, Li B, Zhao W, etal |title=Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese |journal=Ann. Hum. Genet. |volume=70 |issue= Pt 6 |pages= 778–83 |year= 2006 |pmid= 17044852 |doi= 10.1111/j.1469-1809.2006.00278.x }}
  • {{cite journal |vauthors=Wang Z, Armando I, Asico LD, etal |title=The elevated blood pressure of human GRK4gamma A142V transgenic mice is not associated with increased ROS production |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=292 |issue= 5 |pages= H2083–92 |year= 2007 |pmid= 17259440 |doi= 10.1152/ajpheart.00944.2006 }}
{{refend}}{{Serine/threonine-specific protein kinases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{gene-4-stub}}

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