| 词条 | GSK1360707F |
| 释义 |
| Watchedfields = changed | verifiedrevid = 451604166 | IUPAC_name = (1R,6S)-1-(3,4-Dichlorophenyl)-6-(methoxymethyl)-4-azabicyclo[4.1.0]heptane | image = GSK1360707F.svg | width = 200 | tradename = | CAS_number = | ATC_prefix = | ATC_suffix = | PubChem = 24802841 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID = 32739425 | C=14 | H=17 | Cl=2 | N=1 | O=1 | molecular_weight = 286.196 g/mol | smiles = COC[C@@]12C[C@@]1(CCNC2)c3ccc(c(c3)Cl)Cl | StdInChI = 1S/C14H17Cl2NO/c1-18-9-13-7-14(13,4-5-17-8-13)10-2-3-11(15)12(16)6-10/h2-3,6,17H,4-5,7-9H2,1H3/t13-,14-/m0/s1 | StdInChIKey = ICXJGCSEMJXNQF-KBPBESRZSA-N }} GSK1360707F is a potent and selective triple reuptake inhibitor.[1] structurally related to amitifadine and NS-2359 (GSK-372,475). Synthesis
PETGSK1360707F has recently (2013) been tested on baboons (Papio anubis) & humans for transporter occupancy.[5] {{cquote|until recently was under development for the treatment of major depressive disorder; its development was put on hold for strategic reasons.}}References1. ^{{Cite journal | last1 = Micheli | first1 = F. | last2 = Cavanni | first2 = P. | last3 = Andreotti | first3 = D. | last4 = Arban | first4 = R. | last5 = Benedetti | first5 = R. | last6 = Bertani | first6 = B. | last7 = Bettati | first7 = M. | last8 = Bettelini | first8 = L. | last9 = Bonanomi | first9 = G. | last10 = Braggio | doi = 10.1021/jm100481d | first10 = S. | last11 = Carletti | first11 = R. | last12 = Checchia | first12 = A. | last13 = Corsi | first13 = M. | last14 = Fazzolari | first14 = E. | last15 = Fontana | first15 = S. | last16 = Marchioro | first16 = C. | last17 = Merlo-Pich | first17 = E. | last18 = Negri | first18 = M. | last19 = Oliosi | first19 = B. | last20 = Ratti | first20 = E. | last21 = Read | first21 = K. D. | last22 = Roscic | first22 = M. | last23 = Sartori | first23 = I. | last24 = Spada | first24 = S. | last25 = Tedesco | first25 = G. | last26 = Tarsi | first26 = L. | last27 = Terreni | first27 = S. | last28 = Visentini | first28 = F. | last29 = Zocchi | first29 = A. | last30 = Zonzini | first30 = L. | title = 6-(3,4-Dichlorophenyl)-1-[(Methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: A New Potent and Selective Triple Reuptake Inhibitor | journal = Journal of Medicinal Chemistry | volume = 53 | issue = 13 | pages = 4989–5001 | year = 2010 | pmid = 20527970 | pmc = }} {{Serotonergics}}{{Adrenergics}}{{Dopaminergics}}2. ^{{cite doi|10.1021/op100139f}} 3. ^{{cite doi|10.1016/j.tetlet.2011.05.005}} 4. ^{{Cite pmid|21174473}} 5. ^{{Cite journal | doi = 10.1124/jpet.112.202895| pmid = 23685546| title = Monoamine Transporter Occupancy of a Novel Triple Reuptake Inhibitor in Baboons and Humans Using Positron Emission Tomography| journal = Journal of Pharmacology and Experimental Therapeutics| volume = 346| issue = 2| pages = 311–7| year = 2013| last1 = Comley | first1 = R. A.| last2 = Salinas | first2 = C. A.| last3 = Slifstein | first3 = M.| last4 = Petrone | first4 = M.| last5 = Marzano | first5 = C.| last6 = Bennacef | first6 = I.| last7 = Shotbolt | first7 = P.| last8 = Van Der Aart | first8 = J.| last9 = Neve | first9 = M.| last10 = Iavarone | first10 = L.| last11 = Gomeni | first11 = R.| last12 = Laruelle | first12 = M.| last13 = Gray | first13 = F. A.| last14 = Gunn | first14 = R. N.| last15 = Rabiner | first15 = E. A.}} 1 : Serotonin-norepinephrine-dopamine reuptake inhibitors |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。