释义 |
- References
- Further reading
{{Infobox_gene}}Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene.[1][2][3]This gene encodes a member of the theta class glutathione S-transferase-like (GSTTL) protein family. In mouse, the encoded protein acts as a small stress response protein, likely involved in cellular redox homeostasis.[3] This protein has dehydroascorbate reductase activity and may function in the glutathione-ascorbate cycle as part of antioxidant metabolism.[4] References1. ^{{cite journal |vauthors=Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk BA, Perregaux DE, Gabel CA, Geoghegan KF, Pandit J | title = Identification, characterization, and crystal structure of the Omega class glutathione transferases | journal = J Biol Chem | volume = 275 | issue = 32 | pages = 24798–806 |date=Sep 2000 | pmid = 10783391 | pmc = | doi = 10.1074/jbc.M001706200 }} 2. ^{{cite journal |vauthors=Whitbread AK, Tetlow N, Eyre HJ, Sutherland GR, Board PG | title = Characterization of the human Omega class glutathione transferase genes and associated polymorphisms | journal = Pharmacogenetics | volume = 13 | issue = 3 | pages = 131–44 |date=Mar 2003 | pmid = 12618591 | pmc = | doi = 10.1097/01.fpc.0000054062.98065.6e }} 3. ^1 {{cite web | title = Entrez Gene: GSTO1 glutathione S-transferase omega 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9446| accessdate = }} 4. ^{{cite journal |vauthors=Whitbread AK, Masoumi A, Tetlow N, Schmuck E, Coggan M, Board PG |title=Characterization of the omega class of glutathione transferases |journal=Meth. Enzymol. |volume=401 |issue= |pages=78–99 |year=2005 |pmid=16399380 |doi=10.1016/S0076-6879(05)01005-0 |series=Methods in Enzymology |isbn=978-0-12-182806-6}}
Further reading{{refbegin | 2}}- {{cite journal | author=Matoba R |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression |journal=Gene |volume=146 |issue= 2 |pages= 199–207 |year= 1994 |pmid= 8076819 |doi=10.1016/0378-1119(94)90293-3 |name-list-format=vanc| author2=Okubo K | author3=Hori N | display-authors=3 | last4=Atsushi | first4=Fukushima | last5=Kenichi | first5=Matsubara }}
- {{cite journal |vauthors=Ishikawa T, Casini AF, Nishikimi M |title=Molecular cloning and functional expression of rat liver glutathione-dependent dehydroascorbate reductase |journal=J. Biol. Chem. |volume=273 |issue= 44 |pages= 28708–12 |year= 1998 |pmid= 9786866 |doi=10.1074/jbc.273.44.28708 }}
- {{cite journal |vauthors=Kodym R, Calkins P, Story M |title=The cloning and characterization of a new stress response protein. A mammalian member of a family of theta class glutathione s-transferase-like proteins |journal=J. Biol. Chem. |volume=274 |issue= 8 |pages= 5131–7 |year= 1999 |pmid= 9988762 |doi=10.1074/jbc.274.8.5131 }}
- {{cite journal |vauthors=Hubbard MJ, McHugh NJ |title=Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping |journal=Electrophoresis |volume=21 |issue= 17 |pages= 3785–96 |year= 2001 |pmid= 11271497 |doi= 10.1002/1522-2683(200011)21:17<3785::AID-ELPS3785>3.0.CO;2-2 }}
- {{cite journal |vauthors=Yin ZL, Dahlstrom JE, Le Couteur DG, Board PG |title=Immunohistochemistry of omega class glutathione S-transferase in human tissues |journal=J. Histochem. Cytochem. |volume=49 |issue= 8 |pages= 983–7 |year= 2001 |pmid= 11457926 |doi=10.1177/002215540104900806 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
- {{cite journal | author=Tanaka-Kagawa T |title=Functional characterization of two variant human GSTO 1-1s (Ala140Asp and Thr217Asn) |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 2 |pages= 516–20 |year= 2003 |pmid= 12565892 |doi=10.1016/S0006-291X(02)03066-8 |name-list-format=vanc| author2=Jinno H | author3=Hasegawa T | display-authors=3 | last4=Makino | first4=Yuko | last5=Seko | first5=Yoshiyuki | last6=Hanioka | first6=Nobumitsu | last7=Ando | first7=Masanori }}
- {{cite journal | author=Yu L |title=Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans |journal=Environ. Health Perspect. |volume=111 |issue= 11 |pages= 1421–7 |year= 2004 |pmid= 12928150 |doi= 10.1289/ehp.6420| pmc=1241635 |name-list-format=vanc| author2=Kalla K | author3=Guthrie E | display-authors=3 | last4=Vidrine | first4=Amy | last5=Klimecki | first5=Walter T. }}
- {{cite journal | author=Li YJ |title=Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease |journal=Hum. Mol. Genet. |volume=12 |issue= 24 |pages= 3259–67 |year= 2004 |pmid= 14570706 |doi= 10.1093/hmg/ddg357 |name-list-format=vanc| author2=Oliveira SA | author3=Xu P | display-authors=3 | last4=Martin | first4=ER | last5=Stenger | first5=JE | last6=Scherzer | first6=CR | last7=Hauser | first7=MA | last8=Scott | first8=WK | last9=Small | first9=GW }}
- {{cite journal | author=Whitbread AK |title=Glutathione transferase Omega class polymorphisms in Parkinson disease |journal=Neurology |volume=62 |issue= 10 |pages= 1910–1 |year= 2004 |pmid= 15159516 |doi= 10.1212/01.wnl.0000125282.09308.b1|name-list-format=vanc| author2=Mellick GD | author3=Silburn PA | display-authors=3 | last4=Le Couteur | first4=DG | last5=Board | first5=PG }}
- {{cite journal | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 10 |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |name-list-format=vanc| author2=Earthrowl ME | author3=Grafham DV | display-authors=3 | last4=Rubenfield | first4=M. | last5=French | first5=L. | last6=Steward | first6=C. A. | last7=Sims | first7=S. K. | last8=Jones | first8=M. C. | last9=Searle | first9=S. }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Kölsch H |title=Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke |journal=Neurology |volume=63 |issue= 12 |pages= 2255–60 |year= 2005 |pmid= 15623683 |doi= 10.1212/01.wnl.0000147294.29309.47|name-list-format=vanc| author2=Linnebank M | author3=Lütjohann D | display-authors=3 | last4=Jessen | first4=F | last5=Wüllner | first5=U | last6=Harbrecht | first6=U | last7=Thelen | first7=KM | last8=Kreis | first8=M | last9=Hentschel | first9=F }}
- {{cite journal | author=Ozturk A |title=Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease |journal=Neurobiol. Aging |volume=26 |issue= 8 |pages= 1161–5 |year= 2005 |pmid= 15917099 |doi= 10.1016/j.neurobiolaging.2004.11.001 |name-list-format=vanc| author2=Desai PP | author3=Minster RL | display-authors=3 | last4=Dekosky | first4=Steven T. | last5=Kamboh | first5=M. Ilyas }}
- {{cite journal | author=Stelzl U |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |name-list-format=vanc| author2=Worm U | author3=Lalowski M | display-authors=3 | last4=Haenig | first4=Christian | last5=Brembeck | first5=Felix H. | last6=Goehler | first6=Heike | last7=Stroedicke | first7=Martin | last8=Zenkner | first8=Martina | last9=Schoenherr | first9=Anke }}
- {{cite journal |vauthors=Fujihara J, Kunito T, Takeshita H |title=Frequency of two human glutathione-S-transferase omega-1 polymorphisms (E155 deletion and E208K) in Ovambo and Japanese populations using the PCR-based genotyping method |journal=Clin. Chem. Lab. Med. |volume=45 |issue= 5 |pages= 621–4 |year= 2007 |pmid= 17484623 |doi= 10.1515/CCLM.2007.128 }}
- {{cite journal | author=Harju TH |title=Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients |journal=Respir. Res. |volume=8 |issue= 1|pages= 48 |year= 2007 |pmid= 17617905 |doi= 10.1186/1465-9921-8-48 | pmc=1939846 |name-list-format=vanc| author2=Peltoniemi MJ | author3=Rytilä PH | display-authors=3 | last4=Soini | first4=Ylermi | last5=Salmenkivi | first5=Kaisa M | last6=Board | first6=Philip G | last7=Ruddock | first7=Lloyd W | last8=Kinnula | first8=Vuokko L }}
- {{cite journal | author=Kölsch H |title=Association of the glutathione S-transferase omega-1 Ala140Asp polymorphism with cerebrovascular atherosclerosis and plaque-associated interleukin-1 alpha expression |journal=Stroke |volume=38 |issue= 10 |pages= 2847–50 |year= 2007 |pmid= 17717316 |doi= 10.1161/STROKEAHA.107.484162 |name-list-format=vanc| author2=Larionov S | author3=Dedeck O | display-authors=3 | last4=Orantes | first4=M. | last5=Birkenmeier | first5=G. | last6=Griffin | first6=W. S. T. | last7=Thal | first7=D. R. }}
{{refend}}{{PDB Gallery|geneid=9446}}{{gene-10-stub}} |