“GTP cyclohydrolase IIa”的意思、由来-开放百科全书

词条

GTP cyclohydrolase IIa

释义

References

{{enzyme
| Name = GTP cyclohydrolase IIa
| EC_number = 3.5.4.29
| CAS_number =
| IUBMB_EC_number = 3/5/4/29
| GO_code = 0043740
| image =
| width =
| caption =
}}

In enzymology, a GTP cyclohydrolase IIa ({{EC number|3.5.4.29}}) is an enzyme that catalyzes the chemical reaction

GTP + 3 H₂O 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + 2 phosphate

Thus, the two substrates of this enzyme are GTP and H₂O, whereas its two products are 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one and phosphate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is GTP 8,9-hydrolase (phosphate-forming).

References

{{cite journal |vauthors=Graham DE, Xu H, White RH | date = 2002 | title = A member of a new class of GTP cyclohydrolases produces formylaminopyrimidine nucleotide monophosphates | journal = Biochemistry | volume = 41 | pages = 15074–84 | pmid = 12475257 | doi = 10.1021/bi0268798 | issue = 50 }}

{{Carbon-nitrogen non-peptide hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{3.5-enzyme-stub}}

2 : EC 3.5.4|Enzymes of unknown structure

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。