“GTP diphosphokinase”的意思、由来-开放百科全书

词条

GTP diphosphokinase

释义

Structural studies
References

{{enzyme
| Name = GTP diphosphokinase
| EC_number = 2.7.6.5
| CAS_number = 63690-89-1
| IUBMB_EC_number = 2/7/6/5
| GO_code = 0008728
| image =
| width =
| caption =
}}

In enzymology, a GTP diphosphokinase ({{EC number|2.7.6.5}}) is an enzyme that catalyzes the chemical reaction

ATP + GTP AMP + guanosine 3'-diphosphate 5'-triphosphate

Thus, the two substrates of this enzyme are ATP and GTP, whereas its two products are AMP and guanosine 3'-diphosphate 5'-triphosphate.

This enzyme belongs to the family of transferases, specifically those transferring two phosphorus-containing groups (diphosphotransferases). The systematic name of this enzyme class is ATP:GTP 3'-diphosphotransferase. Other names in common use include stringent factor, guanosine 3',5'-polyphosphate synthase, GTP pyrophosphokinase, ATP-GTP 3'-diphosphotransferase, guanosine 5',3'-polyphosphate synthetase, (p)ppGpp synthetase I, (p)ppGpp synthetase II, guanosine pentaphosphate synthetase, GPSI, and GPSII. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1E3H}}, {{PDB link|1E3P}}, {{PDB link|1VJ7}}, and {{PDB link|2BE3}}.

References

{{cite journal |vauthors=Fehr S, Richter D | date = 1981 | title = Stringent response of Bacillus stearothermophilus: evidence for the existence of two distinct guanosine 3',5'-polyphosphate synthetases | journal = J. Bacteriol. | volume = 145 | pages = 68–73 | pmid = 6161916 | issue = 1 | pmc = 217245 }}
{{cite journal |vauthors=Sy J, Akers H | date = 1976 | title = Purification and properties of guanosine 5', 3'-polyphosphate synthetase from Bacillus brevis | journal = Biochemistry | volume = 15 | pages = 4399–403 | pmid = 184817 | doi = 10.1021/bi00665a008 | issue = 20 }}

2 : EC 2.7.6|Enzymes of known structure

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