| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene.[1][2] Function Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.[2] Mutations in this gene have been associated to cases of myocardial infarction (10.1038/nature12722). References1. ^{{cite journal |vauthors=Giuili G, Scholl U, Bulle F, Guellaen G | title = Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain | journal = FEBS Lett | volume = 304 | issue = 1 | pages = 83–8 |date=Jul 1992 | pmid = 1352257 | pmc = | doi =10.1016/0014-5793(92)80594-7 }}
2. ^1 {{cite web | title = Entrez Gene: GUCY1A3 guanylate cyclase 1, soluble, alpha 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2982| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Giuili G, Roechel N, Scholl U, etal |title=Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33. |journal=Hum. Genet. |volume=91 |issue= 3 |pages= 257–60 |year= 1993 |pmid= 8097486 |doi=10.1007/BF00218267 }}
- {{cite journal |vauthors=Papapetropoulos A, Cziraki A, Rubin JW, etal |title=cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue. |journal=J. Cell. Physiol. |volume=167 |issue= 2 |pages= 213–21 |year= 1996 |pmid= 8613461 |doi= 10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S }}
- {{cite journal |vauthors=Zabel U, Weeger M, La M, Schmidt HH |title=Human soluble guanylate cyclase: functional expression and revised isoenzyme family. |journal=Biochem. J. |volume=335 |issue= 1|pages= 51–7 |year= 1998 |pmid= 9742212 |doi= | pmc=1219751 }}
- {{cite journal |vauthors=Zhou Y, Zheng JB, Gu X, etal |title=A novel Pax-6 binding site in rodent B1 repetitive elements: coevolution between developmental regulation and repeated elements? |journal=Gene |volume=245 |issue= 2 |pages= 319–28 |year= 2000 |pmid= 10717483 |doi=10.1016/S0378-1119(00)00019-6 }}
- {{cite journal |vauthors=Behrends S, Vehse K, Scholz H, etal |title=Assignment of GUCY1A3, a candidate gene for hypertension, to human chromosome bands 4q31.1→q31.2 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3–4 |pages= 204–5 |year= 2000 |pmid= 10828587 |doi=10.1159/000015548 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Saino M, Maruyama T, Sekiya T, etal |title=Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3 |journal=Oncol. Rep. |volume=12 |issue= 1 |pages= 47–52 |year= 2005 |pmid= 15201957 |doi= 10.3892/or.12.1.47}}
- {{cite journal |vauthors=Meurer S, Pioch S, Wagner K, etal |title=AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase |journal=J. Biol. Chem. |volume=279 |issue= 47 |pages= 49346–54 |year= 2005 |pmid= 15381706 |doi= 10.1074/jbc.M410565200 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
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