| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.[1][2] Function Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.[2] Interactions GUCY1B3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1[3] and Endothelial NOS.[3] References 1. ^{{cite journal |vauthors=Giuili G, Scholl U, Bulle F, Guellaën G | title = Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain | journal = FEBS Lett | volume = 304 | issue = 1 | pages = 83–8 | date = Jul 1992 | pmid = 1352257 | pmc = | doi = 10.1016/0014-5793(92)80594-7 }}
2. ^1 {{cite web | title = Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2983| accessdate = }}
3. ^1 {{cite journal |vauthors=Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD | title = Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase | journal = Am. J. Physiol. Heart Circ. Physiol. | volume = 285 | issue = 2 | pages = H669–78 | date = Aug 2003 | pmid = 12676772 | doi = 10.1152/ajpheart.01025.2002 }}
Further reading {{refbegin | 2}}- {{cite journal |vauthors=Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA | title = Guanylyl cyclases and signaling by cyclic GMP | journal = Pharmacol. Rev. | volume = 52 | issue = 3 | pages = 375–414 | year = 2000 | pmid = 10977868 | doi = }}
- {{cite journal |vauthors=Chhajlani V, Frändberg PA, Ahlner J, Axelsson KL, Wikberg JE | title = Heterogeneity in human soluble guanylate cyclase due to alternative splicing | journal = FEBS Lett. | volume = 290 | issue = 1–2 | pages = 157–8 | year = 1991 | pmid = 1680753 | doi = 10.1016/0014-5793(91)81248-7 }}
- {{cite journal |vauthors=Giuili G, Roechel N, Scholl U, Mattei MG, Guellaen G | title = Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33 | journal = Hum. Genet. | volume = 91 | issue = 3 | pages = 257–60 | year = 1993 | pmid = 8097486 | doi = 10.1007/BF00218267 }}
- {{cite journal |vauthors=Papapetropoulos A, Cziraki A, Rubin JW, Stone CD, Catravas JD | title = cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue | journal = J. Cell. Physiol. | volume = 167 | issue = 2 | pages = 213–21 | year = 1996 | pmid = 8613461 | doi = 10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S }}
- {{cite journal |vauthors=Zabel U, Weeger M, La M, Schmidt HH | title = Human soluble guanylate cyclase: functional expression and revised isoenzyme family | journal = Biochem. J. | volume = 335 | issue = 1 | pages = 51–7 | year = 1998 | pmid = 9742212 | pmc = 1219751 | doi = }}
- {{cite journal |vauthors=Russwurm M, Wittau N, Koesling D | title = Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes | journal = J. Biol. Chem. | volume = 276 | issue = 48 | pages = 44647–52 | year = 2002 | pmid = 11572861 | doi = 10.1074/jbc.M105587200 }}
- {{cite journal |vauthors=Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD | title = Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase | journal = Am. J. Physiol. Heart Circ. Physiol. | volume = 285 | issue = 2 | pages = H669–78 | year = 2003 | pmid = 12676772 | doi = 10.1152/ajpheart.01025.2002 }}
- {{cite journal |vauthors=Meurer S, Pioch S, Wagner K, Müller-Esterl W, Gross S | title = AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase | journal = J. Biol. Chem. | volume = 279 | issue = 47 | pages = 49346–54 | year = 2005 | pmid = 15381706 | doi = 10.1074/jbc.M410565200 }}
- {{cite journal |vauthors=Mateos-Cáceres PJ, Garcia-Cardoso J, Lapuente L, Zamorano-León JJ, Sacristán D, de Prada TP, Calahorra J, Macaya C, Vela-Navarrete R, López-Farré AJ | title = Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction | journal = Int. J. Impot. Res. | volume = 18 | issue = 5 | pages = 432–7 | year = 2006 | pmid = 16528291 | doi = 10.1038/sj.ijir.3901461 }}
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