| 词条 | GW-803430 |
| 释义 |
| verifiedrevid = 434884863 | IUPAC_name = 6-(4-chlorophenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one | image = GW-803,430_structure.png | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number = 515141-51-2 | ATC_prefix = none | ATC_suffix = | PubChem = 9826520 | DrugBank = | ChemSpiderID = 8002263 | C=25 | H=24 | Cl=1 | N=3 | O=3 | S=1 | molecular_weight = 481.993 g/mol | smiles = C5CCCN5CCOc3ccc(cc3OC)-n1cnc2cc(sc2c1=O)-c(cc4)ccc4Cl | StdInChI = 1S/C25H24ClN3O3S/c1-31-22-14-19(8-9-21(22)32-13-12-28-10-2-3-11-28)29-16-27-20-15-23(33-24(20)25(29)30)17-4-6-18(26)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3 | StdInChIKey = MWULMTACIBZPGN-UHFFFAOYSA-N }}GW-803430 (GW-3430) is a drug used in scientific research and is a selective non-peptide antagonist at the melanin concentrating hormone receptor MCH1. In animal studies it has anxiolytic, antidepressant and anorectic effects.[1][2] References1. ^Chaki S, Kanuma K. Neuropeptide receptors: Novel therapeutic targets for depression and anxiety disorders. Drugs of the Future. 2007;32(9):809. {{Antidepressants}}{{Anxiolytics}}{{Anorectics}}{{Neuropeptidergics}}{{gastrointestinal-drug-stub}}{{nervous-system-drug-stub}}2. ^{{cite journal |vauthors=Gehlert DR, Rasmussen K, Shaw J, Li X, Ardayfio P, Craft L, Coskun T, Zhang HY, Chen Y, Witkin JM |title=Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=329 |issue=2 |pages=429–38 |date=May 2009 |pmid=19182070 |doi=10.1124/jpet.108.143362 |url=}} 7 : Antidepressants|Anxiolytics|Anorectics|Pyrrolidines|Phenol ethers|Lactams|Chloroarenes |
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