“H1FOO”的意思、由来-开放百科全书

词条

H1FOO

释义

Function
References
Further reading

{{Infobox_gene}}Histone H1oo is a protein that in humans is encoded by the H1FOO gene.^[1]^[2]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.^[2]

It incorporates into sperm chromatin after fertilisation.^[3]

References

1. ^{{cite journal |vauthors=Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ | title = The human and mouse replication-dependent histone genes | journal = Genomics | volume = 80 | issue = 5 | pages = 487–98 |date=November 2002 | pmid = 12408966 | doi = 10.1016/S0888-7543(02)96850-3| url = }}
2. ^¹{{cite web | title = Entrez Gene: H1 histone family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=132243| accessdate = }}
3. ^{{cite journal |vauthors=Mizusawa Y, Kuji N, Tanaka Y, etal |title=Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization |journal=Fertil Steril |volume=93 |issue=4 |pages=1134–1141 |date=March 2010 |pmid=19147139 |doi=10.1016/j.fertnstert.2008.11.028 |url=}}

{{cite journal |vauthors=Teranishi T, Tanaka M, Kimoto S, etal |title=Rapid replacement of somatic linker histones with the oocyte-specific linker histone H1foo in nuclear transfer. |journal=Dev. Biol. |volume=266 |issue= 1 |pages= 76–86 |year= 2004 |pmid= 14729479 |doi=10.1016/j.ydbio.2003.10.004 }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |pmc=139241 |doi= 10.1073/pnas.242603899 }}
{{cite journal |vauthors=Tanaka Y, Kato S, Tanaka M, etal |title=Structure and expression of the human oocyte-specific histone H1 gene elucidated by direct RT-nested PCR of a single oocyte |journal=Biochem. Biophys. Res. Commun. |volume=304 |issue= 2 |pages= 351–7 |year= 2003 |pmid= 12711322 |doi=10.1016/S0006-291X(03)00610-7 }}
{{cite journal |vauthors=Tanaka M, Kihara M, Hennebold JD, etal |title=H1FOO is coupled to the initiation of oocytic growth |journal=Biol. Reprod. |volume=72 |issue= 1 |pages= 135–42 |year= 2005 |pmid= 15371275 |doi= 10.1095/biolreprod.104.032474 }}
{{cite journal |vauthors=Gao S, Chung YG, Parseghian MH, etal |title=Rapid H1 linker histone transitions following fertilization or somatic cell nuclear transfer: evidence for a uniform developmental program in mice |journal=Dev. Biol. |volume=266 |issue= 1 |pages= 62–75 |year= 2004 |pmid= 14729478 |doi=10.1016/j.ydbio.2003.10.003 }}

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

Function

References

Further reading