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词条 HDAC9
释义

  1. Function

  2. Interactions

  3. See also

  4. References

  5. Further reading

  6. External links

{{Infobox_gene}}Histone deacetylase 9 is an enzyme that in humans is encoded by the HDAC9 gene.[1][2][3]

Function

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.[3]

Interactions

HDAC9 has been shown to interact with:

{{div col|colwidth=20em}}
  • CBX5,[4]
  • HDAC3,[6][5]
  • BTG2, [6]
  • Myocyte-specific enhancer factor 2A[7][8]
  • Nuclear receptor co-repressor 1,[6]
  • SIN3A,[9][10] and
  • SUV39H1.[4]
{{Div col end}}

See also

  • Histone deacetylase
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References

1. ^{{cite journal | vauthors = Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ | title = HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7816–27 | date = November 1999 | pmid = 10523670 | pmc = 84849 | doi = 10.1128/mcb.19.11.7816 }}
2. ^{{cite journal | vauthors = Sparrow DB, Miska EA, Langley E, Reynaud-Deonauth S, Kotecha S, Towers N, Spohr G, Kouzarides T, Mohun TJ | title = MEF-2 function is modified by a novel co-repressor, MITR | journal = The EMBO Journal | volume = 18 | issue = 18 | pages = 5085–98 | date = September 1999 | pmid = 10487760 | pmc = 1171579 | doi = 10.1093/emboj/18.18.5085 }}
3. ^1 {{cite web | title = Entrez Gene: HDAC9 histone deacetylase 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9734| accessdate = }}
4. ^1 {{cite journal | vauthors = Zhang CL, McKinsey TA, Olson EN | title = Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation | journal = Molecular and Cellular Biology | volume = 22 | issue = 20 | pages = 7302–12 | date = October 2002 | pmid = 12242305 | pmc = 139799 | doi = 10.1128/mcb.22.20.7302-7312.2002 }}
5. ^{{cite journal | vauthors = Zhou X, Richon VM, Rifkind RA, Marks PA | title = Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 3 | pages = 1056–61 | date = February 2000 | pmid = 10655483 | pmc = 15519 | doi = 10.1073/pnas.97.3.1056 }}
6. ^{{cite journal | vauthors = Micheli L, D'Andrea G, Leonardi L, Tirone F | title = HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progression and Cyclin D1 Expression | journal = Journal of Cellular Physiology | volume = 232 | issue = 7 | pages = 1696–1707 | date = July 2017 | pmid = 27333946 | doi = 10.1002/jcp.25467 | url = http://www.inmm.cnr.it/tirone/pdfs/Micheli_et_al-2017-J_Cell_Physiol%20PC3-HDACs.pdf }}
7. ^{{cite journal | vauthors = Miska EA, Karlsson C, Langley E, Nielsen SJ, Pines J, Kouzarides T | title = HDAC4 deacetylase associates with and represses the MEF2 transcription factor | journal = The EMBO Journal | volume = 18 | issue = 18 | pages = 5099–107 | date = September 1999 | pmid = 10487761 | pmc = 1171580 | doi = 10.1093/emboj/18.18.5099 }}
8. ^{{cite journal | vauthors = Lemercier C, Verdel A, Galloo B, Curtet S, Brocard MP, Khochbin S | title = mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity | journal = The Journal of Biological Chemistry | volume = 275 | issue = 20 | pages = 15594–9 | date = May 2000 | pmid = 10748098 | doi = 10.1074/jbc.M908437199 }}
9. ^1 2 {{cite journal | vauthors = Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A | title = The histone deacetylase 9 gene encodes multiple protein isoforms | journal = The Journal of Biological Chemistry | volume = 278 | issue = 18 | pages = 16059–72 | date = May 2003 | pmid = 12590135 | doi = 10.1074/jbc.M212935200 }}
10. ^{{cite journal | vauthors = Koipally J, Georgopoulos K | title = Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression | journal = The Journal of Biological Chemistry | volume = 277 | issue = 26 | pages = 23143–9 | date = June 2002 | pmid = 11959865 | doi = 10.1074/jbc.M202079200 }}

Further reading

{{refbegin|33em}}
  • {{cite journal | vauthors = Marks PA, Richon VM, Rifkind RA | title = Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells | journal = Journal of the National Cancer Institute | volume = 92 | issue = 15 | pages = 1210–6 | date = August 2000 | pmid = 10922406 | doi = 10.1093/jnci/92.15.1210 }}
  • {{cite journal | vauthors = Verdin E, Dequiedt F, Kasler HG | title = Class II histone deacetylases: versatile regulators | journal = Trends in Genetics | volume = 19 | issue = 5 | pages = 286–93 | date = May 2003 | pmid = 12711221 | doi = 10.1016/S0168-9525(03)00073-8 }}
  • {{cite journal | title = Toward a complete human genome sequence | journal = Genome Research | volume = 8 | issue = 11 | pages = 1097–108 | date = November 1998 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 | last1 = Sanger Centre | first1 = The | last2 = Washington University Genome Sequencing Cente | first2 = The }}
  • {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 5 | pages = 277–86 | date = October 1998 | pmid = 9872452 | doi = 10.1093/dnares/5.5.277 }}
  • {{cite journal | vauthors = Miska EA, Karlsson C, Langley E, Nielsen SJ, Pines J, Kouzarides T | title = HDAC4 deacetylase associates with and represses the MEF2 transcription factor | journal = The EMBO Journal | volume = 18 | issue = 18 | pages = 5099–107 | date = September 1999 | pmid = 10487761 | pmc = 1171580 | doi = 10.1093/emboj/18.18.5099 }}
  • {{cite journal | vauthors = Zhou X, Richon VM, Rifkind RA, Marks PA | title = Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 3 | pages = 1056–61 | date = February 2000 | pmid = 10655483 | pmc = 15519 | doi = 10.1073/pnas.97.3.1056 }}
  • {{cite journal | vauthors = Youn HD, Grozinger CM, Liu JO | title = Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 29 | pages = 22563–7 | date = July 2000 | pmid = 10825153 | doi = 10.1074/jbc.C000304200 }}
  • {{cite journal | vauthors = Zhang CL, McKinsey TA, Lu JR, Olson EN | title = Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor | journal = The Journal of Biological Chemistry | volume = 276 | issue = 1 | pages = 35–9 | date = January 2001 | pmid = 11022042 | doi = 10.1074/jbc.M007364200 }}
  • {{cite journal | vauthors = Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E | title = Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo | journal = The Journal of Biological Chemistry | volume = 276 | issue = 38 | pages = 35826–35 | date = September 2001 | pmid = 11466315 | doi = 10.1074/jbc.M104935200 }}
  • {{cite journal | vauthors = Zhou X, Marks PA, Rifkind RA, Richon VM | title = Cloning and characterization of a histone deacetylase, HDAC9 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 19 | pages = 10572–7 | date = September 2001 | pmid = 11535832 | pmc = 58507 | doi = 10.1073/pnas.191375098 }}
  • {{cite journal | vauthors = Koipally J, Georgopoulos K | title = Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression | journal = The Journal of Biological Chemistry | volume = 277 | issue = 26 | pages = 23143–9 | date = June 2002 | pmid = 11959865 | doi = 10.1074/jbc.M202079200 }}
  • {{cite journal | vauthors = Kirsh O, Seeler JS, Pichler A, Gast A, Müller S, Miska E, Mathieu M, Harel-Bellan A, Kouzarides T, Melchior F, Dejean A | title = The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase | journal = The EMBO Journal | volume = 21 | issue = 11 | pages = 2682–91 | date = June 2002 | pmid = 12032081 | pmc = 125385 | doi = 10.1093/emboj/21.11.2682 }}
  • {{cite journal | vauthors = Mahlknecht U, Schnittger S, Will J, Cicek N, Hoelzer D | title = Chromosomal organization and localization of the human histone deacetylase 9 gene (HDAC9) | journal = Biochemical and Biophysical Research Communications | volume = 293 | issue = 1 | pages = 182–91 | date = April 2002 | pmid = 12054582 | doi = 10.1016/S0006-291X(02)00193-6 }}
  • {{cite journal | vauthors = Zhang CL, McKinsey TA, Olson EN | title = Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation | journal = Molecular and Cellular Biology | volume = 22 | issue = 20 | pages = 7302–12 | date = October 2002 | pmid = 12242305 | pmc = 139799 | doi = 10.1128/MCB.22.20.7302-7312.2002 }}
  • {{cite journal | vauthors = Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N | title = The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies | journal = Oncogene | volume = 21 | issue = 43 | pages = 6703–12 | date = September 2002 | pmid = 12242670 | doi = 10.1038/sj.onc.1205882 }}
  • {{cite journal | vauthors = Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A | title = The histone deacetylase 9 gene encodes multiple protein isoforms | journal = The Journal of Biological Chemistry | volume = 278 | issue = 18 | pages = 16059–72 | date = May 2003 | pmid = 12590135 | doi = 10.1074/jbc.M212935200 }}
{{refend}}

External links

  • {{MeshName|HDAC9+protein,+human}}
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