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词条 Health effects of sunlight exposure
释义

  1. Synthesis of vitamin D3

  2. Lower prevalence of multiple sclerosis

  3. Risks to skin

  4. Benefits of optic exposure

  5. Effects on eyes

  6. Folate degradation

  7. Safe level of sun exposure

  8. Lifetime sun exposure

  9. See also

  10. References

{{use mdy dates|date=March 2015}}

The ultraviolet radiation in sunlight has both positive and negative health effects, as it is both a principal source of vitamin D3 and a mutagen.[1] A dietary supplement can supply vitamin D without this mutagenic effect.[2] Vitamin D has been suggested as having a wide range of positive health effects, which include strengthening bones[3] and possibly inhibiting the growth of some cancers.[4][5] UV exposure also has positive effects for endorphin levels, and possibly for protection against multiple sclerosis. Visible sunlight to the eyes gives health benefits through its association with the timing of melatonin synthesis, maintenance of normal and robust circadian rhythms, and reduced risk of seasonal affective disorder.[6]

Long-term sunlight exposure is known to be associated with the development of some types of skin cancer, skin aging, immune suppression, and eye diseases such as cataracts and macular degeneration.[7][8]

Since UV rays, and therefore sunlight and sunlamps, are carcinogens that also have health benefits,[9] a number of public health organizations state that there needs to be a balance between the risks of having too much sunlight or too little.[8] There is a general consensus that sunburn should always be avoided.

Synthesis of vitamin D3

{{Main|Vitamin D}} UVB radiation with a wavelength of 290–315 nanometers penetrates uncovered skin and converts cutaneous 7-dehydrocholesterol to previtamin D3, which in turn becomes vitamin D3.[9][10][11] UVB radiation does not penetrate glass, so exposure to sunshine indoors through a window does not produce vitamin D.[12] Time of day, time of year, geographic latitude, ground altitude, cloud cover, smog, skin melanin content, and sunscreen are among the factors that greatly affect UV intensity and vitamin D synthesis,[11] making it difficult to provide general guidelines. It has been suggested by some researchers, for example, that adequate amounts of vitamin D can be produced with moderate sun exposure to the face, arms and legs, averaging 5–30 minutes twice per week without sunscreen. (The darker the complexion, or the weaker the sunlight, the more minutes of exposure are needed, approximating 25% of the time for minimal sunburn. Vitamin D overdose is impossible from UV exposure; the skin reaches an equilibrium where the vitamin degrades as fast as it is created.)[11][13][14] Individuals with limited sun exposure need to include good sources of vitamin D in their diet or take a supplement.

The only way to quantify adequate levels of vitamin D is with a serum 25(OH)D3 (calcifediol) test.[15] In the United States, serum 25(OH)D3 was below the recommended level for more than a third of white men in a 2005 study, with serum levels even lower in women and in most minorities. This indicates that vitamin D deficiency may be a common problem in the US.[16] Australia and New Zealand have had similar findings, which indicate insufficient protection against rickets for children and osteoporosis for adults.[17]

Over the past several years, levels of ultraviolet radiation have been tracked at over 30 sites across North America as part of the United States Department of Agriculture's UVB Monitoring and Research Program at Colorado State University. The first map at right shows levels of UVB radiation in June 2008, expressed in Vitamin D Equivalents.[18]

Using satellite data, measurements from the European Space Agency produce similar maps expressed in units of the widely followed UV Index, for locations around the world.[19] Effects of UV-radiation at high latitudes, where snow stays on the ground into early summer and the sun then remains at a low position even at its zenith, have been reviewed by Meyer-Rochow.[20]

Exposure to ultraviolet radiation from the sun is a source of vitamin D. One minimal erythemal dose of sunlight UV radiation provides the equivalent of about 20,000 IU of vitamin D2, taken as an oral supplement.{{citation needed|date=January 2018}} If an adult's arms and legs are exposed to a half minimal erythemal UV radiation, it is the same as taking 3,000 IU of vitamin D3 through an oral supplement. This exposure of 10–15 minutes, on a frequency of two to three times per week will cause the adult's skin to produce enough vitamin D. It is not necessary to expose the face to the UV, as facial skin provides little vitamin D3. Individuals whose metabolism makes taking oral vitamin D ineffective are able, through exposure to an ultraviolet lamp that emits UV-B radiation, to achieve a 25 (OH) D blood level.[21]

Three benefits of UV exposure are production of vitamin D, improvement in mood, and increased energy.[22]

UVB induces production of vitamin D in the skin at rates of up to 1,000 IUs per minute. This vitamin helps to regulate calcium metabolism (vital for the nervous system and bone health), immunity, cell proliferation, insulin secretion, and blood pressure.[23] In third-world countries, foods fortified with vitamin D are "practically nonexistent." Most people in the world depend on the sun to get vitamin D.[24]

There are not many foods that naturally have vitamin D.[25] Examples are cod liver oil and oily fish. If people cannot get sunlight, then they will need 1,000 IU of vitamin D per day to stay healthy.[26] A person would have to eat oily fish three or four times per week in order to get enough vitamin D from that food source alone.

People with higher levels of vitamin D tend to have lower rates of diabetes, heart disease, and stroke and tend to have lower blood pressure. However, it has been found that vitamin D supplementation does not improve cardiovascular health or metabolism, so the link with vitamin D must be in part indirect.{{citation needed|date=January 2018}} People who get more sun are generally healthier, and also have higher vitamin D levels. It has been found that ultraviolet radiation (even UVA) produces nitric oxide (NO) in the skin, and nitric oxide can lower blood pressure. High blood pressure increases the risk of stroke and heart disease. Although long-term exposure to ultraviolet contributes to non-melanoma skin cancers that are rarely fatal, it has been found in a Danish study that those who get these cancers were less likely to die during the study, and were much less likely to have a heart attack, than those who did not have these cancers.[27]

People in certain situations, such as people with intellectual disabilities and neurodevelopmental disorders who stay inside most of the time have low vitamin D levels. Getting enough vitamin D can help stave off "autoimmune diseases, cardiovascular disease, many types of cancer, dementia, types 1 and 2 diabetes mellitus, and respiratory tract infections."[28]

Fetuses and children who do not get enough vitamin D can suffer from "growth retardation and skeletal deformities."[25]

Lower prevalence of multiple sclerosis

Multiple sclerosis (MS) is least prevalent in the sunniest regions.[29][30][31] Exposure to the ultraviolet-B radiation of sunlight appears to be most important and this may operate via vitamin D synthesis.[32]

Risks to skin

Ultraviolet (UV) irradiation present in sunlight is an environmental human carcinogen. The toxic effects of UV from natural sunlight and therapeutic artificial lamps are a major concern for human health. The major acute effects of UV irradiation on normal human skin comprise sunburn inflammation erythema, tanning, and local or systemic immunosuppression.[33] The most deadly form, malignant melanoma, is mostly caused by indirect DNA damage from UVA radiation. This can be seen from the absence of a direct UV signature mutation in 92% of all melanoma.[34] UVC is the highest-energy, most-dangerous type of ultraviolet radiation, and causes adverse effects that can variously be mutagenic or carcinogenic.[35]

Despite the importance of the sun to vitamin D synthesis, it is prudent to limit the exposure of skin to UV radiation from sunlight[36] and from tanning beds.[37] According to the National Toxicology Program Report on Carcinogens from the US Department of Health and Human Services, broad-spectrum UV radiation is a carcinogen whose DNA damage is thought to contribute to most of the estimated 1.5 million skin cancers and the 8,000 deaths due to metastatic melanoma that occur annually in the United States.[36][38] The use of sunbeds is reported by the World Health Organization to be responsible for over 450,000 cases of non-melanoma skin cancer and over 10,000 cases of melanoma every year in the U.S., Europe, as well as Australia.[39] Lifetime cumulative UV exposure to skin is also responsible for significant age-associated dryness, wrinkling, elastin and collagen damage, freckling, age spots and other cosmetic changes. The American Academy of Dermatology advises that photoprotective measures be taken, including the use of sunscreen, whenever one is exposed to the sun.[40] Short-term over-exposure causes the pain and itching of sunburn, which in extreme cases can produce more-severe effects like blistering.

Several countries (such as Australia) provide public forecasts of UV irradiation in the form of the UV Index. The index can be used as a guide to the public of dangers from over-exposure to sunlight, especially at noon, when direct sunlight is at its most intense.

Benefits of optic exposure

Light to the eyes, primarily blue-wavelength light, is important for the entrainment and maintenance of robust circadian rhythms. Exposure to sunlight in the morning is particularly effective; it leads to earlier melatonin onset in the evening and makes it easier to fall asleep. Bright morning light has been shown to be effective against insomnia, premenstrual syndrome and seasonal affective disorder (SAD).[6]

Effects on eyes

Prolonged optical exposure to sunlight, especially intense ultraviolet light, may be linked to cortical cataracts,[41][20] and high levels of visible light may be linked to macular degeneration.

However, significant daily exposure to bright light may be necessary for children to avoid myopia (nearsightedness).[42]

Short-term over-exposure can cause snow blindness, which is analogous to sunburn of the cornea, or can cause solar retinopathy, which is long-lasting retinal damage and vision impairment from sungazing.[43][44]

Frequent exposure to the sun can cause yellow non-cancerous bumps on the middle part of the sclera of the eye, called pingueculae. It is most common in younger people, mainly those who spend a lot of their time outdoors and do not protect their eyes from UV rays. To decrease the risk of developing pingueculae, it may be wise to wear sunglasses when outdoors, even on overcast days.[45]

Folate degradation

Blood levels of folate, a nutrient vital for fetal development, can be degraded by UV radiation,[46] raising concerns about sun exposure for pregnant women.[47] Lifespan and fertility can be adversely affected for individuals born during peaks of the 11-year solar cycle, possibly because of UV-related folate deficiency during gestation.[48]

Safe level of sun exposure

According to a 2007 study submitted by the University of Ottawa to the US Department of Health and Human Services, there is not enough information to determine a safe level of sun exposure that imposes minimal risk of skin cancer.[49] In addition, there is not yet conclusive evidence on which components of ultraviolet radiation (UVA, UVB, UVC) are actually carcinogenic.[50] UVC is almost completely absorbed by the atmosphere and does not reach the surface in any appreciable quantity.[51] As a result, only the broad-spectrum combination (UVA, UVB, UVC) known as "ultraviolet radiation" is listed as a carcinogen; the components are only "likely to become" known carcinogens. Solar radiation (sunlight) and sunlamps are listed as carcinogens because they contain ultraviolet radiation.[50]

Lifetime sun exposure

There are currently no recommendations on a safe level of total lifetime sun exposure.[49] According to epidemiologist Robyn Lucas at Australian National University, analysis of lifespan versus disease shows that far more lives worldwide could be lost to diseases caused by lack of sunlight than to those caused by too much,[52] and it is inappropriate to recommend total avoidance of sunlight.[53]

Over thousands of years, in many climate zones, genetic selection has helped indigenous human populations adapt toward skin pigmentation levels that provide a healthy level of UV exposure. This largely explains the tendency toward darker-skinned populations in the sunniest tropical environments, and lighter skin tones in less-sunny regions and for those who most need vitamin D for rapid bone growth, specifically children and reproductive-age women. The map below illustrates the geographic distribution of skin color for native populations prior to 1940, based on von Luschan's chromatic scale. These long-term adaptations for optimal health can be confounded by patterns of food, clothing and shelter, especially at a time when large populations have migrated far from the climates for which their skin was genetically adapted.[54][55]

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See also

{{Portal|Health and fitness}}
  • Fluorescent lamps and health
  • Heat stroke
  • Photosensitivity in humans
  • UV Index

References

1. ^{{cite journal | pmid = 12174089 | volume=147 | issue=2 | title=Vitamin D and systemic cancer: is this relevant to malignant melanoma? |date=August 2002 | journal=Br. J. Dermatol. | pages=197–213 |vauthors=Osborne JE, Hutchinson PE | doi = 10.1046/j.1365-2133.2002.04960.x}}
2. ^{{cite web|url=http://dietary-supplements.info.nih.gov/factsheets/vitamind.asp|title= Dietary Supplement Fact Sheet: Vitamin D|publisher=Office of Dietary Supplements, National Institutes of Health}}
3. ^{{cite journal |vauthors=Cranney A, Horsley T, O'Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, Fang M, Yazdi F, Garritty C, Sampson M, Barrowman N, Tsertsvadze A, Mamaladze V | title = Effectiveness and safety of vitamin D in relation to bone health | journal = Evidence Report/technology Assessment | issue = 158 | pages = 1–235 | date = August 2007 | pmid = 18088161 | pmc=4781354}}
4. ^{{cite journal |vauthors=John E, Schwartz G, Koo J, Van Den Berg D, Ingles S | title = Sun Exposure, Vitamin D Receptor Gene Polymorphisms, and Risk of Advanced Prostate Cancer | journal = Cancer Research | volume = 65 | issue = 12 | pages = 5470–5479 | date = June 15, 2005 | doi=10.1158/0008-5472.can-04-3134 | pmid=15958597}}
5. ^{{cite journal |vauthors=Egan K, Sosman J, Blot W | title = Sunlight and Reduced Risk of Cancer: Is The Real Story Vitamin D? | journal = J Natl Cancer Inst | volume = 97 | issue = 3 | pages = 161–163 | date = February 2, 2005 | url = http://jnci.oxfordjournals.org/content/97/3/161.full | doi = 10.1093/jnci/dji047 | pmid = 15687354 }}
6. ^1 {{cite journal |author=Mead MN |title=Benefits of sunlight: a bright spot for human health |journal=Environmental Health Perspectives |volume=116 |issue=4 |pages=A160–A167 |date=April 2008 |pmid=18414615 |pmc=2290997 |doi=10.1289/ehp.116-a160}}
7. ^{{cite journal |vauthors=Lucas RM, Repacholi MH, McMichael AJ |title=Is the current public health message on UV exposure correct? |journal=Bulletin of the World Health Organization |volume=84 |issue=6 |pages=485–491 |date=June 2006 |pmid=16799733 |pmc=2627377 |doi=10.2471/BLT.05.026559}}
8. ^{{cite web |url=http://www.cancer.org.au/content/pdf/CancerControlPolicy/PositionStatements/PSRisksBenefitsSunExposure03May07.pdf |title=Risks and Benefits of Sun Exposure |publisher=Cancer Council Australia |date=May 3, 2007 |accessdate=March 25, 2015}}
9. ^{{cite journal |vauthors=Hayes CE, Nashold FE, Spach KM, Pedersen LB |title=The immunological functions of the vitamin D endocrine system |journal=Cellular and Molecular Biology |volume=49 |issue=2 |pages=277–300 |date=March 2003 |pmid=12887108}}
10. ^{{cite journal |author=Holick MF |title=McCollum Award Lecture, 1994: vitamin D—new horizons for the 21st century |journal=The American Journal of Clinical Nutrition |volume=60 |issue=4 |pages=619–630 |date=October 1994 |pmid=8092101 |url=http://www.ajcn.org/cgi/pmidlookup?view=long&pmid=8092101|doi=10.1093/ajcn/60.4.619 }}
11. ^1 2 {{cite journal |first1=MF |last1=Holick |date=February 2002 |title=Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellular health |journal=Current Opinion in Endocrinology, Diabetes and Obesity |volume=9 |issue=1 |pages=87–98 |doi=10.1097/00060793-200202000-00011}}
12. ^{{cite book |author=Holick MF |chapter=Photobiology of vitamin D |editor1=Feldman, David Henry |editor2=Glorieux, Francis H. |title=Vitamin D |publisher=Elsevier Academic Press |location=Amsterdam |year=2005 |pages= |isbn=978-0-12-252687-9}}
13. ^{{cite journal |author=Holick MF |title=Sunlight and Vitamin D |journal=Journal of General Internal Medicine |volume=17 |issue=9 |pages=733–735 |date=September 2002 |pmc=1495109 |doi=10.1046/j.1525-1497.2002.20731.x |pmid=12220371}}
14. ^{{cite journal |author=Holick MF |title=Vitamin D deficiency |journal=The New England Journal of Medicine |volume=357 |issue=3 |pages=266–281 |date=July 2007 |pmid=17634462 |doi=10.1056/NEJMra070553}}
15. ^{{cite web|url=https://www.nlm.nih.gov/medlineplus/ency/article/003569.htm |title=25-hydroxy vitamin D test |website=MedlinePlus |first=S |last=Topiwala |publisher=US National Institutes of Health |date=July 19, 2012 |accessdate=March 25, 2015}}
16. ^{{cite journal |vauthors=Zadshir A, Tareen N, Pan D, Norris K, Martins D |title=The prevalence of hypovitaminosis D among US adults: data from the NHANES III |journal=Ethnicity & Disease |volume=15 |issue=4 Suppl 5 |pages=S5–97 – S5–101 |year=2005 |pmid=16315387}}
17. ^{{cite journal|vauthors=Nowson C, Margerison C |title=Vitamin D intake and vitamin D status of Australians |url=http://www.mja.com.au/public/issues/177_03_050802/now10763_fm.html |journal=Med J Aust |volume=177 |issue=3 |pages=149–152 |year=2002 |pmid=12149085}}
18. ^{{cite web |url=http://uvb.nrel.colostate.edu/UVB/index.jsf |title=UV-B Monitoring and Research Program |publisher=Colorado State University |accessdate=May 13, 2010}}
19. ^{{cite web |url=http://temis.nl/uvradiation/GOME/uvclim.php?fb=uviec&Clim=17 |title=UV index & UV dose based on GOME |publisher=KNMI/TEMIS |accessdate=March 17, 2015}}
20. ^1 2 {{cite journal| last=Meyer-Rochow|first= Victor Benno|title= Risks, especially for the eye, emanating from the rise of solar UV-radiation in the Arctic and Antarcticregions|journal=International Journal of Circumpolar Health| year=2000|volume=59|issue= 1|pages=38–51|pmid= 10850006}}
21. ^{{cite journal|last1=Hossein-nezhad|first1=Arash|last2=Holick|first2=Michael F.|title=Vitamin D for Health: A Global Perspective|journal=Mayo Clinic Proceedings|date=July 2013|volume=88|issue=7|pages=720–755|doi=10.1016/j.mayocp.2013.05.011|pmid=23790560|pmc=3761874}}
22. ^{{cite journal|last1=Sivamani|first1=RK|last2=Crane|first2=LA|last3=Dellavalle|first3=RP|title=The benefits and risks of ultraviolet tanning and its alternatives: the role of prudent sun exposure.|journal=Dermatologic Clinics|date=April 2009|volume=27|issue=2|pages=149–54, vi|pmid=19254658|doi=10.1016/j.det.2008.11.008|pmc=2692214}}
23. ^{{cite web |url=http://lpi.oregonstate.edu/infocenter/vitamins/vitaminD/ |title=Vitamin D |publisher=Oregon State University |accessdate=2011-11-08 |deadurl=no |archiveurl=https://web.archive.org/web/20111026135239/http://lpi.oregonstate.edu/infocenter/vitamins/vitaminD/ |archivedate=26 October 2011 |df=dmy-all }}
24. ^{{cite journal|last1=Gupta|first1=Piyush|last2=Shah|first2=Dheeraj|title=Vitamin D deficiency: Is the pandemic for real?|journal=Indian Journal of Community Medicine|date=2015|volume=40|issue=4|pages=215–7|doi=10.4103/0970-0218.164378|pmc=4581139|pmid=26435592}}
25. ^1 {{cite journal|last1=Holick|first1=MF|title=Vitamin D deficiency.|journal=The New England Journal of Medicine|date=19 July 2007|volume=357|issue=3|pages=266–81|doi=10.1056/NEJMra070553|pmid=17634462}}
26. ^{{cite journal|last1=Holick|first1=MF|title=Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis.|journal=The American Journal of Clinical Nutrition|date=March 2004|volume=79|issue=3|pages=362–71|pmid=14985208|doi=10.1093/ajcn/79.3.362}}
27. ^{{cite journal|author1=Richard Weller|title=Shunning the sun may be killing you in more ways than you think|journal=New Scientist|date=Jun 10, 2015|url=https://www.newscientist.com/article/mg22630250-500-shunning-the-sun-may-be-killing-you-in-more-ways-than-you-think|deadurl=no|archiveurl=https://web.archive.org/web/20170609062643/https://www.newscientist.com/article/mg22630250-500-shunning-the-sun-may-be-killing-you-in-more-ways-than-you-think/|archivedate=9 June 2017|df=dmy-all}}
28. ^{{cite journal|last1=Grant|first1=WB|last2=Wimalawansa|first2=SJ|last3=Holick|first3=MF|last4=Cannell|first4=JJ|last5=Pludowski|first5=P|last6=Lappe|first6=JM|last7=Pittaway|first7=M|last8=May|first8=P|title=Emphasizing the health benefits of vitamin D for those with neurodevelopmental disorders and intellectual disabilities.|journal=Nutrients|date=27 February 2015|volume=7|issue=3|pages=1538–64|doi=10.3390/nu7031538|pmid=25734565|pmc=4377865}}
29. ^{{cite journal |vauthors=Ascherio A, Munger KL | title = Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors | journal = Annals of Neurology | volume = 61 | issue = 6 | pages = 504–513 | date = June 2007 | pmid = 17492755 | doi = 10.1002/ana.21141 }}
30. ^{{cite journal |vauthors=Milo R, Kahana E | title = Multiple sclerosis: geoepidemiology, genetics and the environment | journal = Autoimmun Rev | volume = 9 | issue = 5 | pages = A387–A394 | date = March 2010 | pmid = 19932200 | doi = 10.1016/j.autrev.2009.11.010 }}
31. ^{{cite journal |vauthors=Ascherio A, Munger KL, Simon KC | title = Vitamin D and multiple sclerosis | journal = Lancet Neurol | volume = 9 | issue = 6 | pages = 599–612 | date = June 2010 | pmid = 20494325 | doi = 10.1016/S1474-4422(10)70086-7 }}
32. ^{{cite journal |authors=Koch MW, Metz LM, Agrawal SM, Yong VW |title=Environmental factors and their regulation of immunity in multiple sclerosis |journal=J. Neurol. Sci. |volume=324 |issue=1–2 |pages=10–16 |year=2013 |pmid=23154080 |doi=10.1016/j.jns.2012.10.021 |url=}}
33. ^{{cite journal | title = Toxic effects of ultraviolet radiation on the skin | last = Matsumu | first = Y. | last2 = Ananthaswamy | first2 = H. N. | year = 2004 | journal = Toxicology and Applied Pharmacology | volume = 195 | issue = 3 | pages = 298–308 | doi = 10.1016/j.taap.2003.08.019 | pmid = 15020192}}
34. ^{{cite journal |author1=Davies H. |author2=Bignell G. R. |author3=Cox C. |date=June 2002 |title= Mutations of the BRAF gene in human cancer |journal= Nature |volume= 417 |issue= 6892|pages=949–954 | doi = 10.1038/nature00766 |pmid=12068308}}
35. ^C.Michael Hogan. 2011. Sunlight. eds. P.Saundry & C.Cleveland. Encyclopedia of Earth.
36. ^1 {{cite journal |vauthors=Wolpowitz D, Gilchrest BA |title=The vitamin D questions: how much do you need and how should you get it? |journal=Journal of the American Academy of Dermatology |volume=54 |issue=2 |pages=301–317 |date=February 2006 |pmid=16443061 |doi=10.1016/j.jaad.2005.11.1057}}
37. ^{{cite journal |title=The association of use of sunbeds with cutaneous malignant melanoma and other skin cancers: A systematic review |journal=International Journal of Cancer |volume=120 |issue=5 |pages=1116–1122 |date=March 2007 |pmid=17131335 |doi=10.1002/ijc.22453 |author1= International Agency for Research on Cancer Working Group on artificial ultraviolet (UV) light and skin cancer}}
38. ^{{cite web|url=https://ntp.niehs.nih.gov/pubhealth/roc/listings/archive/index.html?substance=Ultraviolet+Radiation|archive-url=https://web.archive.org/web/20100528035215/http://ntp.niehs.nih.gov/index.cfm?objectid=BD4CD88D-F1F6-975E-792094AC1CE4B062 |archive-date=2010-05-28 |title=Ultraviolet (UV) Radiation, Broad Spectrum and UVA, UVB, and UVC |publisher=National Toxicology Program |date=January 5, 2009 |accessdate=May 13, 2010}}
39. ^{{Cite web|url=http://www.who.int/uv/en/|title=More can be done to restrict sunbeds to prevent increasing rates of skin cancer|last=|first=|date=|website=World Health Organization|archive-url=|archive-date=|dead-url=|access-date=May 5, 2018}}
40. ^American Academy of Dermatology. Position statement on vitamin D. November 1, 2008.
41. ^{{cite journal |vauthors=West SK, Duncan DD, Muñoz B |display-authors=etal |title=Sunlight exposure and risk of lens opacities in a population-based study: the Salisbury Eye Evaluation project |journal=JAMA |volume=280 |issue=8 |pages=714–718 |year=1998 |pmid=9728643 |doi=10.1001/jama.280.8.714 }}
42. ^{{Cite journal|title = The Myopia Boom|journal = Nature|date = 19 March 2015|last = Dolgin|first = Elie |volume= 519 |issue = 7543|pages= 276–278 |doi=10.1038/519276a |pmid = 25788077|bibcode= 2015Natur.519..276D}}
43. ^{{cite journal |vauthors=Chen JC, Lee LR | year = 2004 | title = Solar retinopathy and associated optical coherence tomography findings | url = http://www.optometrists.asn.au/gui/files/ceo876390.pdf | journal = Clin Exp Optom | volume = 87 | issue = 6 | pages = 390–393 | doi = 10.1111/j.1444-0938.2004.tb03100.x | pmid = 15575813 }}
44. ^{{cite journal |vauthors=Kallmark FP, Ygge J | year = 2005 | title = Photo-induced foveal injury after viewing a solar eclipse | url = | journal = Acta Ophthalmol Scand | volume = 83 | issue = 5 | pages = 586–589 | doi = 10.1111/j.1600-0420.2005.00511.x | pmid = 16187997 }}
45. ^{{cite web|last1=Lusby, MD|first1=Franklin|last2=Zieve, MD, AHA|first2=David|last3=Ogilvie, PhD|first3=Isla|title=Pinguecula|url=https://medlineplus.gov/ency/article/001025.htm|website=MedicinePlus|publisher=U.S. National Library of Medicine|accessdate=28 October 2016}}
46. ^{{cite journal |title=Exposure to solar ultraviolet radiation is associated with a decreased folate status in women of childbearing age |vauthors=Borradale D, Isenring E, Hacker E, Kimlin MG |journal=Journal of Photochemistry and Photobiology B: Biology |volume=131 |date=February 2014 |pages=90–95 |doi=10.1016/j.jphotobiol.2014.01.002|pmid=24509071 }}
47. ^{{cite web |url=http://www.americanpregnancy.org/pregnancyhealth/tanningmethods.html |title=Pregnancy and Tanning |publisher=American Pregnancy Association |date=January 2014 |accessdate=January 11, 2015}}
48. ^{{cite journal |vauthors=Skjærvø GR, Fossøy F, Røskaft E |title=Solar activity at birth predicted infant survival and women's fertility in historical Norway |journal=Proc. R. Soc. B |volume=282 |issue=1801 |date=February 2015 |pmid=25567646 |doi=10.1098/rspb.2014.2032 |pages=20142032 |pmc=4308994}}
49. ^1 {{cite journal |vauthors=Cranney A, Horsley T, O'Donnell S |display-authors=etal |title=Effectiveness and safety of vitamin D in relation to bone health |journal=Evidence Report/Technology Assessment |volume= |issue=158 |pages=1–235 |date=August 2007 |pmid=18088161 |pmc=4781354}}
50. ^1 2 {{cite web|url=http://ntp.niehs.nih.gov/ntp/roc/content/profiles/ultravioletradiationrelatedexposures.pdf |title=13th Report on Carcinogens: Ultraviolet-Radiation-Related Exposures |publisher=National Toxicology Program |date=October 2014 |accessdate=December 22, 2014}}
51. ^{{cite web |url=http://dermatology.about.com/od/glossaryu/g/uvc.htm |title=UVC Radiation |first=H |last=Brannon |publisher=About.com |date=January 1, 2014 |accessdate=March 25, 2015}}
52. ^{{cite journal |authors=Lucas RM, McMichael AJ, Armstrong BK, Smith WT |title=Estimating the global disease burden due to ultraviolet radiation exposure |url=http://ije.oxfordjournals.org/content/37/3/654.full.pdf |journal=International Journal of Epidemiology |volume=37 |issue=3 |pages=654–667 |doi=10.1093/ije/dyn017 |date=June 2008 |pmid=18276627}}
53. ^{{cite journal |vauthors=Lucas RM, Ponsonby AL |title=Ultraviolet radiation and health: friend and foe |journal=Medical Journal of Australia |volume=177 |issue=11 |pages=594–598 |date=December 2002 |url=https://www.mja.com.au/journal/2002/177/11/ultraviolet-radiation-and-health-friend-and-foe |accessdate=March 24, 2015}}
54. ^{{cite journal |last=Webb |first=AR |title=Who, what, where, and when: influences on cutaneous vitamin D synthesis |journal=Progress in Biophysics and Molecular Biology |volume=92 |issue=1 |pages=17–25 |pmid=16766240 |year=2006 |doi=10.1016/j.pbiomolbio.2006.02.004}}
55. ^{{cite book |last=Jablonski |first=Nina |title=Living Color |year=2012 |publisher=University of California Press |isbn=978-0-520-25153-3}}
{{Health effects of}}

3 : Health effects by subject|Sun tanning|Vitamin D
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