Helen MacDonald may refer to:

• Helen MacDonald (Prince Edward Island politician) (born 1947), member of the Prince Edward Island Legislative Assembly from 2000 to 2007
• Helen MacDonald of Glenaladale (died ca 1803), estate manager on Prince Edward Island
• Helen MacDonald (Nova Scotia politician), Canadian politician, former leader of the New Democrats
• Helen Macdonald (writer), British author, winner of 2014 Costa Book Awards

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