| 词条 | Helen M. Berman |
| 释义 |
| name = Helen Berman | birth_name = Helen Miriam Berman | native_name_lang = | image = berman-photo.jpg | image_size = | alt = Helen Berman in 2008. | caption = Helen Berman in 2008. | birth_date = {{Birth year and age|1943}} | birth_place = Chicago, Illinois | death_date = | signature_alt = | footnotes = | spouse = {{Plainlist|
| children = Jason Asher Young{{citation needed|date=April 2015}} | website = {{URL|http://rutchem.rutgers.edu/berman-helen-m}} }}Helen Miriam Berman is a Board of Governors Professor of Chemistry and Chemical Biology at Rutgers University and a former director of the RCSB Protein Data Bank (one of the member organizations of the Worldwide Protein Data Bank). A structural biologist, her work includes structural analysis of protein-nucleic acid complexes, and the role of water in molecular interactions. She is also the founder and director of the Nucleic Acid Database, and leads the Protein Structure Initiative Structural Genomics Knowledgebase.[1][2][3] Background and educationBerman was born in Chicago, Illinois, and grew up in Brooklyn, New York. Her father, David Bernstein, was a physician and her mother, Dorothy Bernstein (née Skupsky), managed her father's office practice. Inspired by her hard-working and scholarly father, she was interested in science as a young girl and planned to become a scientist or doctor. Her mother, who was strongly involved in the community and volunteer work, influenced her to be involved in community activities throughout her life. During high school, Berman worked in Ingrith Deyrup's laboratory at Barnard College. Deyrup encouraged Berman to attend Barnard as an undergraduate. While at college, she worked in a Columbia University College of Physicians and Surgeons laboratory with Barbara Low. There, Berman learned about crystallography, which would become a lifelong passion. She graduated from Barnard with an A.B. in chemistry in 1964. Following college, Berman attended the University of Pittsburgh for graduate school, a place she selected because it was the only place in the country with a crystallography department, and one of the few where crystallography was offered as a subject. There she worked with George A. Jeffrey on carbohydrate structure, receiving her Ph.D. in 1967. Berman remained at the University of Pittsburgh for two more years as a postdoctoral research fellow. CareerIn 1969, Berman moved to the Fox Chase Cancer Center in Philadelphia, where she worked in Jenny P. Glusker's laboratory before starting her own independent research program as a faculty member in 1973. At Fox Chase, Berman became interested in nucleic acid structures and in bioinformatics. She knew that logical organization of data would make it useful to a variety of scientists. In June 1971, Berman attended a symposium at Cold Spring Harbor Laboratory, where several scientists agreed that data on the expanding number of protein structures should be archived in a database.[4] That meeting led to the creation of the Protein Data Bank (PDB) at Brookhaven National Laboratory.[5][6] In 1989, Berman moved to Rutgers and in 1992, along with other scientists, she co-founded the Nucleic Acid Database (NDB) to collect and disseminate information about nucleic acid structure.[7] At Rutgers, she continued to study nucleic acids, their interactions with proteins,[8] and also researched the structure of collagen in collaboration with Barbara Brodsky and Jordi Bella.[9] She is listed as a depositor on 38 structures in the PDB from 1992 to 2011, of protein/nucleic acid complexes and their components (e.g. 1RUN, 3SSX, 2B1B), collagen fragments (e.g. 1CGD, 1EI8), and other macromolecules. In 1998, Berman and Philip Bourne together competed for and won the contract for the Protein Data Bank and the database moved from Brookhaven to the auspices of the Research Collaboratory for Structural Bioinformatics (RCSB), currently a collaboration between Rutgers and the University of California, San Diego. With colleagues, Berman redesigned the data management system, added new user tools, and made the database searchable.[10] Since 2003, the PDB archive has been managed by the worldwide Protein Data Bank (wwPDB), a partnership founded by Berman that consists of organizations that act as deposition, data processing and distribution centers for PDB data - the RCSB, the PDBe in Europe, and the PDBj in Japan.[11] In 2006 the BioMagResData (BMRB) databank for Nuclear Magnetic Resonance (NMR) structures[12] became the fourth member of the wwPDB.[13] As of July, 2018, the NDB holds over 9600 nucleic acid structures and the PDB holds more than 142,000 macromolecular structures. Also led by the RCSB, the Protein Structure Initiative (PSI) Structural Genomics Knowledgebase was launched in the Spring of 2008 to provide a continuously updated portal to research data and other resources from the PSI efforts.[14] Berman has also been active in the scientific community, serving as president of the American Crystallographic Association in 1988, advising both the National Institutes of Health and the National Science Foundation, and serving on the editorial board of several journals. Her work has been widely published in peer reviewed scientific journals.[8][9][15][16][17] Honors and awards
Personal lifeBerman has been married twice, to engineer Victor Berman in the 1960s, and to molecular biologist Peter Young from 1976 to 1999. From the second marriage she has a son, Jason Asher Young (born 1979), a physicist. During the 1980s, Berman was diagnosed with breast cancer. The experience made her more focused in her life and her career, and interested in supporting other women who face the same diagnosis. References1. ^1 {{GoogleScholar|dCWcLaUAAAAJ}} {{Authority control}}{{ISCB Fellows}}{{DEFAULTSORT:Berman, Helen M.}}2. ^Demasters K: [https://query.nytimes.com/gst/fullpage.html?res=9D0CEFDF173AF935A15752C1A9669C8B63 ON THE MAP; A Bank Where the Currency Is Molecules]. New York Times 2000-11-26. Accessed 2008-10-22. 3. ^Helen Berman’s story{{dead link|date=March 2018 |bot=InternetArchiveBot |fix-attempted=yes }} from Rutgers University Office for the Promotion of Women in Science, Engineering, and Mathematics 4. ^Cold Spring Harbor Symposia on Quantitative Biology, vol. XXXVI (1972) 5. ^{{cite journal |vauthors=Bernstein FC, Koetzle TF, Williams GJ, Meyer EF, Brice MD, Rodgers JR, Kennard O, Shimanouchi T, Tasumi M |title=Protein Data Bank: a computer-based archival file for macromolecular structures |year=1977 |journal=Journal of Molecular Biology |volume=112 |issue=3 |pages=535–542 |doi=10.1016/S0022-2836(77)80200-3 |pmid=875032}} 6. ^{{cite journal |author= Berman H |doi=10.1107/S0108767307035623 |title=The Protein Data Bank: a historical perspective |year=2008 |journal=Acta Crystallographica A |volume=64 |pmid=18156675 |issue=Pt 1 |pages=88–95|bibcode=2008AcCrA..64...88B }} 7. ^About the Nucleic Acid Database {{webarchive|url=https://web.archive.org/web/20080920033203/http://ndbserver.rutgers.edu/about_ndb/index.html |date=2008-09-20 }} 8. ^1 {{cite journal | last = Benoff |first=B. |last2=Yang |first2=H. |last3=Lawson |first3=C. L. |last4=Parkinson |first4=G. |last5=Liu |first5=J. |last6=Blatter |first6=E. |last7=Ebright |first7=Y. W. |last8=Berman |first8=H. M. |last9=Ebright |first9=R. H. |name-list-format=vanc| year = 2002 | title = Structural basis of transcription activation: The CAP-αCTD-DNA complex | url = | journal = Science | volume = 297 | issue = 5586| pages = 1562–1566 | doi=10.1126/science.1076376 | pmid=12202833|bibcode=2002Sci...297.1562B }} 9. ^1 {{cite journal | last = Bella |first=J |last2=Eaton |first2=M |last3=Brodsky |first3=B |last4=Berman |first4=HM|name-list-format=vanc | year = 1994 | title = Crystal and molecular structure of a collagen-like peptide at 1.9 Å resolution | url = | journal = Science | volume = 266 | issue = 5182| pages = 75–81 | doi=10.1126/science.7695699 | pmid=7695699|bibcode=1994Sci...266...75B }} 10. ^{{cite journal |vauthors=Berman HM, Westbrook J, Feng J, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE |title=The Protein Data Bank |year=2000 |journal=Nucleic Acids Research |volume=28 |issue=1 |pages=235–242 |doi=10.1093/nar/28.1.235 |pmid=10592235 |pmc=102472}} 11. ^{{cite journal |vauthors=Berman HM, Henrick K, Nakamura H |year=2003 |title=Announcing the worldwide Protein Data Bank |journal=Nature Structural Biology |volume=10 |pages=980 |doi=10.1038/nsb1203-980 |pmid=14634627 |issue=12}} 12. ^{{Cite journal | pmid = 12766409| year = 2003| author1 = Doreleijers| first1 = J. F.| title = BioMag Res Bank database with sets of experimental NMR constraints corresponding to the structures of over 1400 biomolecules deposited in the Protein Data Bank| journal = Journal of Biomolecular NMR| volume = 26| issue = 2| pages = 139–46| last2 = Mading| first2 = S| last3 = Maziuk| first3 = D| last4 = Sojourner| first4 = K| last5 = Yin| first5 = L| last6 = Zhu| first6 = J| last7 = Markley| first7 = J. L.| last8 = Ulrich| first8 = E. L.}} 13. ^{{cite journal |author1=Berman HM |author2=Henrick K |author3=Nakamura H |author4=John L. Markley JL |title=The worldwide Protein Data Bank (wwPDB): ensuring a single, uniform archive of PDB data |year=2007 |journal=Nucleic Acids Research |volume=35 |issue=Database issue |pages=D301–D303 |pmc=1669775 |pmid=17142228 |doi=10.1093/nar/gkl971 }} 14. ^{{cite journal |vauthors=Kouranov A, Xie L, de la Cruz J, Chen L, Westbrook J, Bourne PE, Berman HM |title=The RCSB PDB information portal for structural genomics |year=2006 |journal=Nucleic Acids Research |volume=34 |pages=D302–D305 |pmc=1347482 |pmid=16381872 |doi=10.1093/nar/gkj120 |issue=Database issue}} 15. ^{{Cite journal | doi = 10.1016/S0006-3495(92)81649-1| title = The nucleic acid database. A comprehensive relational database of three-dimensional structures of nucleic acids| journal = Biophysical Journal| volume = 63| issue = 3| pages = 751–759| year = 1992| last1 = Berman | first1 = H. M. | last2 = Olson | first2 = W. K. | last3 = Beveridge | first3 = D. L. | last4 = Westbrook | first4 = J.| last5 = Gelbin | first5 = A.| last6 = Demeny | first6 = T.| last7 = Hsieh | first7 = S. H. | last8 = Srinivasan | first8 = A. R. | last9 = Schneider | first9 = B. | bibcode=1992BpJ....63..751B | pmid=1384741 | pmc=1262208}} 16. ^{{Cite journal | last1 = Berman | first1 = H. M. | authorlink1 = Helen M. Berman| last2 = Westbrook | first2 = J. | last3 = Feng | first3 = Z. | last4 = Gilliland | first4 = G. | last5 = Bhat | first5 = T. | last6 = Weissig | first6 = H. | last7 = Shindyalov | first7 = I. | last8 = Bourne | first8 = P. | authorlink8 = Philip Bourne| title = The Protein Data Bank | doi = 10.1093/nar/28.1.235 | journal = Nucleic Acids Research | volume = 28 | issue = 1 | pages = 235–242 | year = 2000 | pmid = 10592235| pmc =102472 }} 17. ^{{Cite journal | pmid = 22404998| pmc = 3501388| year = 2012| author1 = Berman| first1 = H. M. | authorlink1 = Helen M. Berman| title = The Protein Data Bank at 40: Reflecting on the past to prepare for the future| journal = Structure| volume = 20| issue = 3| pages = 391–6| last2 = Kleywegt| first2 = G. J. | authorlink2 = Gerard Kleywegt| last3 = Nakamura| first3 = H| last4 = Markley| first4 = J. L.| doi = 10.1016/j.str.2012.01.010}} 18. ^Sigma Xi Distinguished Lecturers 19. ^"Two distinguished Rutgers chemists named Biophysical Society Fellows." Bio-Medicine 20. ^Rutgers Professor Helen M. Berman to Receive the Prestigious M.J. Buerger Award, Rutgers News Release, August 16, 2006 {{webarchive|url=https://web.archive.org/web/20110720112354/http://news.rutgers.edu/medrel/news-releases/2006/08/rutgers-professor-he-20060816 |date=July 20, 2011 }} 21. ^{{cite web|title=Berman recognized for her efforts in removing barriers to data access|url=http://www.asbmb.org/asbmbtoday/asbmbtoday_article.aspx?id=33176&terms=helen%20berman|accessdate=22 January 2015}} 14 : 1943 births|Living people|Barnard College alumni|University of Pittsburgh alumni|Rutgers University faculty|Crystallographers|American biochemists|American biophysicists|Women chemists|American women academics|American women scientists|Fellows of the American Association for the Advancement of Science|Computational chemists|Fellows of the International Society for Computational Biology |
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