“Heptaprenyl diphosphate synthase”的意思、由来-开放百科全书

词条

Heptaprenyl diphosphate synthase

释义

Structural studies
References

{{enzyme
| Name = heptaprenyl diphosphate synthase
| EC_number = 2.5.1.30
| CAS_number = 74506-59-5
| IUBMB_EC_number = 2/5/1/30
| GO_code = 0000010
| image =
| width =
| caption =
}}

In enzymology, a heptaprenyl diphosphate synthase ({{EC number|2.5.1.30}}) is an enzyme that catalyzes the chemical reaction

(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate 4 diphosphate + all-trans-heptaprenyl diphosphate

Thus, the two substrates of this enzyme are (2E,6E)-farnesyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and all-trans-heptaprenyl diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 4 isopentenyl units). Other names in common use include all-trans-heptaprenyl-diphosphate synthase, heptaprenyl pyrophosphate synthase, and heptaprenyl pyrophosphate synthetase. This enzyme participates in biosynthesis of steroids.

Structural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|2E8T}}, {{PDB link|2E8U}}, {{PDB link|2E8V}}, {{PDB link|2E8W}}, {{PDB link|2E8X}}, {{PDB link|2E90}}, {{PDB link|2E91}}, {{PDB link|2E92}}, {{PDB link|2E93}}, {{PDB link|2E94}}, and {{PDB link|2E95}}.

References

{{cite journal |vauthors=Takahashi I, Ogura K, Seto S | date = 1980 | title = Heptaprenyl pyrophosphate synthetase from Bacillus subtilis | journal = J. Biol. Chem. | volume = 255 | pages = 4539–43 | pmid = 6768722 | issue = 10 }}

2 : EC 2.5.1|Enzymes of known structure

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