| 释义 |
- References
- Further reading
- External links
{{Infobox_gene}}Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.[1][2]HES5 regulates brain development process.[3] HES5 expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia.[4] Human HES5 gene binds to Notch receptor and expression of HES5 decreases during cartilage differentiation.[5] References1. ^{{cite journal |vauthors=Takebayashi K, Akazawa C, Nakanishi S, Kageyama R | title = Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element | journal = J Biol Chem | volume = 270 | issue = 3 | pages = 1342–9 |date=Feb 1995 | pmid = 7836401 | pmc = | doi = 10.1074/jbc.270.3.1342}}
2. ^{{cite web | title = Entrez Gene: HES5 hairy and enhancer of split 5 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=388585| accessdate = }}
3. ^{{cite journal |vauthors=Hatakeyama J, Bessho Y, Katoh K, Ookawara S, Fujioka M, Guillemot F, Kageyama R | title = Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation | journal = Development | volume = 131 | issue = 22 | pages = 5539–50 |date=November 2004 | pmid = 15496443 | doi = 10.1242/dev.01436 | url = }}
4. ^{{cite journal |vauthors=Liu J, Ye F, Chen H, Lü W, Zhou C, Xie X | title = Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors | journal = Int. J. Gynecol. Cancer | volume = 17 | issue = 6 | pages = 1293–9 | year = 2007 | pmid = 17388915 | doi = 10.1111/j.1525-1438.2007.00930.x | url = }}
5. ^{{cite journal |vauthors=Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A | title = Notch and HES5 are regulated during human cartilage differentiation | journal = Cell Tissue Res. | volume = 327 | issue = 3 | pages = 539–51 |date=March 2007 | pmid = 17093926 | doi = 10.1007/s00441-006-0307-0 | url = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Gazit R, Krizhanovsky V, Ben-Arie N |title=Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway. |journal=Development |volume=131 |issue= 4 |pages= 903–13 |year= 2004 |pmid= 14757642 |doi= 10.1242/dev.00982 }}
- {{cite journal |vauthors=Nakatani T, Mizuhara E, Minaki Y, etal |title=Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system. |journal=J. Biol. Chem. |volume=279 |issue= 16 |pages= 16356–67 |year= 2004 |pmid= 14764602 |doi= 10.1074/jbc.M311740200 }}
- {{cite journal |vauthors=Kamakura S, Oishi K, Yoshimatsu T, etal |title=Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. |journal=Nat. Cell Biol. |volume=6 |issue= 6 |pages= 547–54 |year= 2004 |pmid= 15156153 |doi= 10.1038/ncb1138 }}
- {{cite journal |vauthors=Katoh M, Katoh M |title=Identification and characterization of human HES2, HES3, and HES5 genes in silico. |journal=Int. J. Oncol. |volume=25 |issue= 2 |pages= 529–34 |year= 2005 |pmid= 15254753 |doi= 10.3892/ijo.25.2.529}}
- {{cite journal |vauthors=Ohtsuka T, Imayoshi I, Shimojo H, etal |title=Visualization of embryonic neural stem cells using Hes promoters in transgenic mice. |journal=Mol. Cell. Neurosci. |volume=31 |issue= 1 |pages= 109–22 |year= 2006 |pmid= 16214363 |doi= 10.1016/j.mcn.2005.09.006 }}
- {{cite journal |vauthors=Ong CT, Cheng HT, Chang LW, etal |title=Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. |journal=J. Biol. Chem. |volume=281 |issue= 8 |pages= 5106–19 |year= 2006 |pmid= 16365048 |doi= 10.1074/jbc.M506108200 }}
- {{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
- {{cite journal |vauthors=Karlsson C, Brantsing C, Svensson T, etal |title=Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors. |journal=J. Orthop. Res. |volume=25 |issue= 2 |pages= 152–63 |year= 2007 |pmid= 17072841 |doi= 10.1002/jor.20287 }}
- {{cite journal |vauthors=Karlsson C, Jonsson M, Asp J, etal |title=Notch and HES5 are regulated during human cartilage differentiation. |journal=Cell Tissue Res. |volume=327 |issue= 3 |pages= 539–51 |year= 2007 |pmid= 17093926 |doi= 10.1007/s00441-006-0307-0 }}
{{refend}} External links - {{MeshName|HES5+protein,+human}}
{{NLM content}}{{Transcription factors|g1}}{{gene-1-stub}} 1 : Transcription factors |