| 释义 |
- References
- Further reading
{{Infobox_gene}}Histone H1.2 is a protein that in humans is encoded by the HIST1H1C gene.[1][2][3]Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3] Apart from its roles in the nucleus, histone H1.2 also participates in apoptosis. In response to apoptotic stimuli, mainly DNA damage, it is translocated from the nucleus to the cytosol. There, it activates Bak, a pro-apoptotic protein bound to the mithochondria outer membrane (MOM). Activation of Bak causes the perforation of the mitochondria, a process known as MOMP (mitochondria outer membrane permeabilization) which promotes apoptosis. Histone H1.2 also forms a complex with the apoptosome, possibly regulating its formation. References1. ^{{cite journal |vauthors=Eick S, Nicolai M, Mumberg D, Doenecke D | title = Human H1 histones: conserved and varied sequence elements in two H1 subtype genes | journal = Eur J Cell Biol | volume = 49 | issue = 1 | pages = 110–5 |date=Sep 1989 | pmid = 2759094 | pmc = | doi = }}
2. ^{{cite journal |vauthors=Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ | title = The human and mouse replication-dependent histone genes | journal = Genomics | volume = 80 | issue = 5 | pages = 487–98 |date=Oct 2002 | pmid = 12408966 | pmc = | doi =10.1016/S0888-7543(02)96850-3 }}
3. ^1 {{cite web | title = Entrez Gene: HIST1H1C histone cluster 1, H1c| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3006| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Ohe Y, Hayashi H, Iwai K |title=Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d. |journal=J. Biochem. |volume=106 |issue= 5 |pages= 844–57 |year= 1990 |pmid= 2613692 |doi= }}
- {{cite journal |vauthors=Eilers A, Bouterfa H, Triebe S, Doenecke D |title=Role of a distal promoter element in the S-phase control of the human H1.2 histone gene transcription. |journal=Eur. J. Biochem. |volume=223 |issue= 2 |pages= 567–74 |year= 1994 |pmid= 8055927 |doi=10.1111/j.1432-1033.1994.tb19026.x }}
- {{cite journal |vauthors=Albig W, Drabent B, Kunz J, etal |title=All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6. |journal=Genomics |volume=16 |issue= 3 |pages= 649–54 |year= 1993 |pmid= 8325638 |doi= 10.1006/geno.1993.1243 }}
- {{cite journal |vauthors=Albig W, Doenecke D |title=The human histone gene cluster at the D6S105 locus. |journal=Hum. Genet. |volume=101 |issue= 3 |pages= 284–94 |year= 1998 |pmid= 9439656 |doi=10.1007/s004390050630 }}
- {{cite journal |vauthors=Richardson RT, Batova IN, Widgren EE, etal |title=Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein. |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30378–86 |year= 2000 |pmid= 10893414 |doi= 10.1074/jbc.M003781200 }}
- {{cite journal |vauthors=Parseghian MH, Newcomb RL, Winokur ST, Hamkalo BA |title=The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts. |journal=Chromosome Res. |volume=8 |issue= 5 |pages= 405–24 |year= 2001 |pmid= 10997781 |doi=10.1023/A:1009262819961 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Garcia BA, Busby SA, Barber CM, etal |title=Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry. |journal=J. Proteome Res. |volume=3 |issue= 6 |pages= 1219–27 |year= 2005 |pmid= 15595731 |doi= 10.1021/pr0498887 }}
- {{cite journal |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
- {{cite journal |vauthors=Duce JA, Smith DP, Blake RE, etal |title=Linker histone H1 binds to disease associated amyloid-like fibrils. |journal=J. Mol. Biol. |volume=361 |issue= 3 |pages= 493–505 |year= 2006 |pmid= 16854430 |doi= 10.1016/j.jmb.2006.06.038 }}
- {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
{{refend}}{{gene-6-stub}} |