| 释义 |
- References
- Further reading
{{Infobox_gene}}Histone H3.1 is a protein that in humans is encoded by the HIST1H3A gene.[1][2][3]Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[3] References1. ^{{cite journal |vauthors=Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D | title = Human histone gene organization: nonregular arrangement within a large cluster | journal = Genomics | volume = 40 | issue = 2 | pages = 314–22 |date=Apr 1997 | pmid = 9119399 | pmc = | doi = 10.1006/geno.1996.4592 }}
2. ^{{cite journal |vauthors=Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ | title = The human and mouse replication-dependent histone genes | journal = Genomics | volume = 80 | issue = 5 | pages = 487–98 |date=Oct 2002 | pmid = 12408966 | pmc = | doi =10.1016/S0888-7543(02)96850-3 }}
3. ^1 {{cite web | title = Entrez Gene: HIST1H3A histone cluster 1, H3a| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8350| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Albig W, Kardalinou E, Drabent B, etal |title=Isolation and characterization of two human H1 histone genes within clusters of core histone genes |journal=Genomics |volume=10 |issue= 4 |pages= 940–8 |year= 1991 |pmid= 1916825 |doi=10.1016/0888-7543(91)90183-F }}
- {{cite journal |vauthors=Albig W, Doenecke D |title=The human histone gene cluster at the D6S105 locus |journal=Hum. Genet. |volume=101 |issue= 3 |pages= 284–94 |year= 1998 |pmid= 9439656 |doi=10.1007/s004390050630 }}
- {{cite journal |vauthors=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535–44 |year= 1998 |pmid= 9566873 |doi= 10.1128/mcb.18.5.2535| pmc=110633 }}
- {{cite journal |vauthors=Ahn J, Gruen JR |title=The genomic organization of the histone clusters on human 6p21.3 |journal=Mamm. Genome |volume=10 |issue= 7 |pages= 768–70 |year= 1999 |pmid= 10384058 |doi=10.1007/s003359901089 }}
- {{cite journal |vauthors=Rea S, Eisenhaber F, O'Carroll D, etal |title=Regulation of chromatin structure by site-specific histone H3 methyltransferases |journal=Nature |volume=406 |issue= 6796 |pages= 593–9 |year= 2000 |pmid= 10949293 |doi= 10.1038/35020506 }}
- {{cite journal |vauthors=Hsu JY, Sun ZW, Li X, etal |title=Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes |journal=Cell |volume=102 |issue= 3 |pages= 279–91 |year= 2000 |pmid= 10975519 |doi=10.1016/S0092-8674(00)00034-9 }}
- {{cite journal |vauthors=Deng L, de la Fuente C, Fu P, etal |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones |journal=Virology |volume=277 |issue= 2 |pages= 278–95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593 }}
- {{cite journal |vauthors=Lachner M, O'Carroll D, Rea S, etal |title=Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins |journal=Nature |volume=410 |issue= 6824 |pages= 116–20 |year= 2001 |pmid= 11242053 |doi= 10.1038/35065132 }}
- {{cite journal |vauthors=Deng L, Wang D, de la Fuente C, etal |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA |journal=Virology |volume=289 |issue= 2 |pages= 312–26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129 }}
- {{cite journal |vauthors=Yang L, Xia L, Wu DY, etal |title=Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor |journal=Oncogene |volume=21 |issue= 1 |pages= 148–52 |year= 2002 |pmid= 11791185 |doi= 10.1038/sj.onc.1204998 }}
- {{cite journal |vauthors=Nielsen PR, Nietlispach D, Mott HR, etal |title=Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9 |journal=Nature |volume=416 |issue= 6876 |pages= 103–7 |year= 2002 |pmid= 11882902 |doi= 10.1038/nature722 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Koessler H, Doenecke D, Albig W |title=Aberrant expression pattern of replication-dependent histone h3 subtype genes in human tumor cell lines |journal=DNA Cell Biol. |volume=22 |issue= 4 |pages= 233–41 |year= 2003 |pmid= 12823900 |doi= 10.1089/104454903321908629 }}
- {{cite journal |vauthors=Coleman MA, Miller KA, Beernink PT, etal |title=Identification of chromatin-related protein interactions using protein microarrays |journal=Proteomics |volume=3 |issue= 11 |pages= 2101–7 |year= 2004 |pmid= 14595808 |doi= 10.1002/pmic.200300593 }}
- {{cite journal |vauthors=Lusic M, Marcello A, Cereseto A, Giacca M |title=Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter |journal=EMBO J. |volume=22 |issue= 24 |pages= 6550–61 |year= 2004 |pmid= 14657027 |doi= 10.1093/emboj/cdg631 | pmc=291826 }}
- {{cite journal |vauthors=Citterio E, Papait R, Nicassio F, etal |title=Np95 is a histone-binding protein endowed with ubiquitin ligase activity |journal=Mol. Cell. Biol. |volume=24 |issue= 6 |pages= 2526–35 |year= 2004 |pmid= 14993289 |doi=10.1128/MCB.24.6.2526-2535.2004 | pmc=355858 }}
{{refend}}{{PDB Gallery|geneid=8350}}{{protein-stub}} |