词条 | HIST1H3I |
释义 |
FunctionHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[4]References1. ^{{cite journal | vauthors = Albig W, Meergans T, Doenecke D | title = Characterization of the H1.5 gene completes the set of human H1 subtype genes | journal = Gene | volume = 184 | issue = 2 | pages = 141–8 | date = January 1997 | pmid = 9031620 | pmc = | doi = 10.1016/S0378-1119(96)00582-3 }} 2. ^{{cite journal | vauthors = Albig W, Doenecke D | title = The human histone gene cluster at the D6S105 locus | journal = Human Genetics | volume = 101 | issue = 3 | pages = 284–94 | date = December 1997 | pmid = 9439656 | pmc = | doi = 10.1007/s004390050630 }} 3. ^{{cite journal | vauthors = Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ | title = The human and mouse replication-dependent histone genes | journal = Genomics | volume = 80 | issue = 5 | pages = 487–98 | date = November 2002 | pmid = 12408966 | pmc = | doi = 10.1016/S0888-7543(02)96850-3 }} 4. ^1 {{cite web | title = Entrez Gene: HIST1H3I histone cluster 1, H3i| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8354| access-date = }} Further reading{{refbegin | 2}}
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