| 释义 |
- References
- Further reading
{{Infobox_gene}}Histone H4 is a protein that in humans is encoded by the HIST1H4A gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[4]
}}References1. ^{{cite journal |vauthors=Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D | title = Human histone gene organization: nonregular arrangement within a large cluster | journal = Genomics | volume = 40 | issue = 2 | pages = 314–22 |date=Apr 1997 | pmid = 9119399 | pmc = | doi = 10.1006/geno.1996.4592 }}
2. ^{{cite journal |vauthors=Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ | title = The human and mouse replication-dependent histone genes | journal = Genomics | volume = 80 | issue = 5 | pages = 487–98 |date=Oct 2002 | pmid = 12408966 | pmc = | doi =10.1016/S0888-7543(02)96850-3 }}
3. ^{{cite web | title = Entrez Gene: HIST1H4A histone cluster 1, H4a| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8359| accessdate = }}
4. ^{{cite web | title = Entrez Gene: HIST1H4A histone cluster 1, H4a| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8359| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Pauli U, Chrysogelos S, Stein G, etal |title=Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. |journal=Science |volume=236 |issue= 4806 |pages= 1308–11 |year= 1987 |pmid= 3035717 |doi=10.1126/science.3035717 }}
- {{cite journal |vauthors=Albig W, Doenecke D |title=The human histone gene cluster at the D6S105 locus. |journal=Hum. Genet. |volume=101 |issue= 3 |pages= 284–94 |year= 1998 |pmid= 9439656 |doi=10.1007/s004390050630 }}
- {{cite journal |vauthors=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535–44 |year= 1998 |pmid= 9566873 |doi= 10.1128/mcb.18.5.2535| pmc=110633 }}
- {{cite journal |vauthors=Lorain S, Quivy JP, Monier-Gavelle F, etal |title=Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5546–56 |year= 1998 |pmid= 9710638 |doi= | pmc=109139 }}
- {{cite journal |vauthors=Deng L, de la Fuente C, Fu P, etal |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. |journal=Virology |volume=277 |issue= 2 |pages= 278–95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593 }}
- {{cite journal |vauthors=Freire J, Covelo G, Sarandeses C, etal |title=Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha. |journal=Biochem. Cell Biol. |volume=79 |issue= 2 |pages= 123–31 |year= 2001 |pmid= 11310559 |doi=10.1139/bcb-79-2-123 }}
- {{cite journal |vauthors=Deng L, Wang D, de la Fuente C, etal |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. |journal=Virology |volume=289 |issue= 2 |pages= 312–26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Yoon HG, Chan DW, Huang ZQ, etal |title=Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. |journal=EMBO J. |volume=22 |issue= 6 |pages= 1336–46 |year= 2003 |pmid= 12628926 |doi= 10.1093/emboj/cdg120 | pmc=151047 }}
- {{cite journal |vauthors=Lusic M, Marcello A, Cereseto A, Giacca M |title=Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6550–61 |year= 2004 |pmid= 14657027 |doi= 10.1093/emboj/cdg631 | pmc=291826 }}
- {{cite journal |vauthors=Phee H, Abraham RT, Weiss A |title=Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. |journal=Nat. Immunol. |volume=6 |issue= 6 |pages= 608–17 |year= 2005 |pmid= 15864311 |doi= 10.1038/ni1199 }}
{{refend}}{{PDB Gallery|geneid=8359}}{{protein-stub}} |