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词条 HLA-B52
释义

  1. Serotype

  2. Alleles

  3. Disease

     In ulcerative colitis  In Takayasu's arteritis 

  4. References

{{Further2|HLA-serotype tutorial}}
B*5101-β2MG with bound peptide {{PDB2|1e27}}
major histocompatibility complex (human), class I, B52
AllelesB*5201, 5202, 5203, . . .
Structure (See HLA-B)
Shared data
Locuschr.6 [https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p21.31 6p21.31]
HLA-B52 (B52) is an HLA-B serotype. The serotype identifies the more common HLA-B*52 gene products.[1]

B52 is a split antigen of the broad antigen B5, and is a sister type of B51. B*5201 likely formed as a result of a gene conversion event between another HLA-B allele and HLA-B*5101.[2]

There are a number of alleles within the B*52 allele group.[3]

Serotype

Serotypes B52, B5, B51, and B53 recognition of HLA B*5201 gene product[4]
B*52B52B5B51B53Sample
allele % % % % size (N)
{{HBA|5201}} 84 2 7 1 2823
Alleles link-out to IMGT/HLA Databease at EBI
{{clear|left}}
HLA *5201 frequencies
freq
ref. Population(%)
[5] China Yunnan Lisu21.7
[5] China Yunnan Nu18.6
[5] Bulgaria Gipsy18.2
[5] Venezuela Sierra de Perija Yucpa12.8
[5] India Andhra Pradesh Golla12.0
[5] Japan Central10.7
[5] Japan10.4
[5] Georgia Tibilisi Kurds10.3
[5] Mali Bandiagara8.3
[5] South Africa Natal Tamil8.2
[5] Israel Ashk. and Non-Ashk. Jews7.3
[5] India North Hindus6.7
[5] China Beijing6.1
[5] India New Delhi6.1
[5] India Mumbai Marathas5.6
[5] Tunisia Ghannouch5.5
[5] Thailand pop35.1
[5] India West Coast Parsis5.0
[5] India North Delhi4.9
[5] Mexico Mestizos4.9
[5] Argentina Toba Rosario4.7
[5] Mexico Zaptotec Oaxaca4.5
[5] USA Hispanic4.5
[5] China Qinghai Hui4.1
[5] China Inner Mongolia3.9
[5] China North Han3.8
[5] Oman3.8
[5] Senegal Niokholo Mandenka3.7
[5] Bulgaria3.6
[5] Thailand3.5
[5] Ivory Coast Akan Adiopodoume3.4
[5] Venezuela Perja Mountain Bari3.4
[5] Italy North pop 13.3
[5] Sudanese3.3
[5] Romanian3.2
[5] Singapore Riau Malay3.0
[5] Autonomous Region Tibetans2.8
[5] Russia Tuva pop 22.8
[5] South Korea pop 32.8
[5] Iran Baloch2.5
[5] Tunisia2.5
[5] Jordan Amman2.4
[5] USA Hawaii Okinawa2.4
[5] Singapore Javanese Indonesians2.0
[5] Spain Eastern Andalusia1.8
[5] Macedonia pop 41.6
[5] Uganda Kampala1.6
[5] Belgium1.5
[5] Mexico Guadalajara Mestizos pop21.5
[5] Singapore Thai1.5
[5] Brazil1.4
[5] China Yunnan Lisu1.4
[5] Azores Santa Maria and Sao Miguel1.3
[5] France South East1.2
[5] Italy North Pavia1.2
[5] Saudi Arabia Guraiat and Hail1.2
[5] Mexico Chihuahua State Tarahumara1.1
[5] Tunisia Tunis1.1
[5] Israel Arab Druse1.0
[5] Japan Ainu Hokkaido1.0
[5] Portugal Centre1.0
[5] Singapore Chinese1.0
[5] Taiwan Minnan pop 11.0
[5] USA Caucasian1.0
[5] Azores Central Islands0.9
[5] China South Han0.9
[5] Macedonia pop 40.7
[5] Morocco Nador Metalsa Class I0.7
[5] Georgia Svaneti Svans0.6
[5] Ireland South0.6
[5] Italy Bergamo0.6

Alleles

There are 18 alleles, with 14 amino acid sequence variants in B52. Of these only 9 are frequent enough to have been reliably serotyped. B*5201 is the most common, but others have a large regional abundance.

Disease

In ulcerative colitis

HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan.[6][7] This form of disease is frequently found with Takayasu's arteritis.[8][9]

In Takayasu's arteritis

Takayasu's arteritis appears to have an independent link to B52 associated disease.[10][11] The association with B*5201 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance.[12]

References

1. ^{{cite journal |vauthors=Marsh SG, Albert ED, Bodmer WF, etal | title = Nomenclature for factors of the HLA system, 2004 | journal = Tissue Antigens | volume = 65 | issue = 4 | pages = 301–69 | year = 2005 | pmid = 15787720 | pmc = 2396006 | doi = 10.1111/j.1399-0039.2005.00379.x }}
2. ^{{cite journal |vauthors=Cox ST, McWhinnie AJ, Robinson J, etal |title=Cloning and sequencing full-length HLA-B and -C genes |journal=Tissue Antigens |volume=61 |issue=1 |pages=20–48 |date=January 2003 |pmid=12622774 |doi=10.1034/j.1399-0039.2003.610103.x |url=http://www.ebi.ac.uk/~sp/intern/projects/pdf_archive/pdfpumped/4/12622774.pdf |archive-url=http://wayback.archive-it.org/all/20081028235823/http://www.ebi.ac.uk/~sp/intern/projects/pdf_archive/pdfpumped/4/12622774.pdf |dead-url=yes |archive-date=2008-10-28 }}
3. ^{{cite journal |vauthors=Hayashi H, Ennis PD, Ariga H, etal |title=HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the helical region of the alpha 1 domain |journal=J. Immunol. |volume=142 |issue=1 |pages=306–11 |date=January 1989 |pmid=2909619 |doi= |url=http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=2909619}}
4. ^derived from IMGT/HLA
5. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 {{cite journal |vauthors=Middleton D, Menchaca L, Rood H, Komerofsky R | title = New allele frequency database: http://www.allelefrequencies.net | journal = Tissue Antigens | volume = 61 | issue = 5 | pages = 403–7 | year = 2003 | pmid = 12753660 | doi =10.1034/j.1399-0039.2003.00062.x }}
6. ^{{cite journal |vauthors=Sugimura K, Asakura H, Mizuki N, etal |title=Analysis of genes within the HLA region affecting susceptibility to ulcerative colitis |journal=Hum. Immunol. |volume=36 |issue=2 |pages=112–8 |date=February 1993 |pmid=8096500 |doi= 10.1016/0198-8859(93)90113-F|url=http://linkinghub.elsevier.com/retrieve/pii/0198-8859(93)90113-F}}
7. ^{{cite journal |vauthors=Nomura E, Kinouchi Y, Negoro K, etal |title=Mapping of a disease susceptibility locus in chromosome 6p in Japanese patients with ulcerative colitis |journal=Genes Immun. |volume=5 |issue=6 |pages=477–83 |date=September 2004 |pmid=15215890 |doi=10.1038/sj.gene.6364114 |url=}}
8. ^{{citation |last=Oyanagi |first=Hironobu |last2=Ishihata |first2=R |last3=Ishikawa |first3=H |title=Ulcerative colitis associated with Takayasu's disease |journal=Intern. Med. |volume=33 |issue=2 |pages=127–129 |date=February 1994 |pmid=7912572 |doi=10.2169/internalmedicine.33.127 |display-authors=etal}}
9. ^{{citation |last=Sato |first=R |last2=Sato |first2=Y |last3=Ishikawa |first3=H |title=Takayasu's disease associated with ulcerative colitis |journal=Intern. Med. |volume=33 |issue=12 |pages=759–763 |date=December 1994 |pmid=7718956 |doi=10.2169/internalmedicine.33.759 |display-authors=etal}}
10. ^{{cite journal |vauthors=Kimura A, Kitamura H, Date Y, Numano F |title=Comprehensive analysis of HLA genes in Takayasu arteritis in Japan |journal=Int. J. Cardiol. |volume=54 Suppl |issue= |pages=S61–9 |date=August 1996 |pmid=9119528 |doi= 10.1016/s0167-5273(96)88774-2|url=}}
11. ^{{cite journal |vauthors=Yoshida M, Kimura A, Katsuragi K, Numano F, Sasazuki T |title=DNA typing of HLA-B gene in Takayasu's arteritis |journal=Tissue Antigens |volume=42 |issue=2 |pages=87–90 |date=August 1993 |pmid=7903491 |doi= 10.1111/j.1399-0039.1993.tb02242.x|url=}}
12. ^{{cite journal |vauthors=Kitamura H, Kobayashi Y, Kimura A, Numano F |title=Association of clinical manifestations with HLA-B alleles in Takayasu arteritis |journal=Int. J. Cardiol. |volume=66 Suppl 1 |issue= |pages=S121–6 |date=October 1998 |pmid=9951811 |doi= 10.1016/S0167-5273(98)00159-4|url=}}
{{HLA-B serotypes}}

1 : HLA-B alleles
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