| 词条 | HLA-B58 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 释义 |
HLA-B58 (B58) is an HLA-B serotype. B58 is a split antigen from the B17 broad antigen, the sister serotype B57.[1] The serotype identifies the more common HLA-B*58 gene products.[2] (For terminology help see: HLA-serotype tutorial) B*5801 is associated with allopurinol induced inflammatory necrotic skin disease. Serotype
Allele distribution
DiseaseHLA-B*5801 is involved in allopurinol sensitive drug induced Stevens–Johnson syndrome.[5][6] Allopurinol is a frequent cause of severe cutaneous adverse reactions, including drug-hypersensitivity syndrome, Stevens–Johnson syndrome, and toxic epidermal necrolysis (SJS/TEN).[7] The association with allopurinol sensitivity in JSJ/TEN was extremely strong in Asia, and somewhat less associated in Europeans.[8] References1. ^{{cite journal |vauthors=Ways JP, Coppin HL, Parham P | title = The complete primary structure of HLA-Bw58 | journal = J. Biol. Chem. | volume = 260 | issue = 22 | pages = 11924–33 | year = 1985 | pmid = 2995352 | doi = }} {{HLA-B serotypes}}2. ^{{cite journal | author = Marsh SG | title = Nomenclature for factors of the HLA system, 2004 | journal = Tissue Antigens | volume = 65 | issue = 4 | pages = 301–69 | year = 2005 | pmid = 15787720 | pmc = 2396006 | doi = 10.1111/j.1399-0039.2005.00379.x |name-list-format=vanc| author2 = Albert ED | author3 = Bodmer WF | display-authors = 3 | last4 = Bontrop | first4 = R.E. | last5 = Dupont | first5 = B. | last6 = Erlich | first6 = H.A. | last7 = Geraghty | first7 = D.E. | last8 = Hansen | first8 = J.A. | last9 = Hurley | first9 = C.K. }} 3. ^derived from IMGT/HLA 4. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 {{cite journal |vauthors=Middleton D, Menchaca L, Rood H, Komerofsky R | title = New allele frequency database: http://www.allelefrequencies.net | journal = Tissue Antigens | volume = 61 | issue = 5 | pages = 403–7 | year = 2003 | pmid = 12753660 | doi =10.1034/j.1399-0039.2003.00062.x }} 5. ^{{cite journal |vauthors=Chung WH, Hung SI, Chen YT |title=Human leukocyte antigens and drug hypersensitivity |journal=Curr Opin Allergy Clin Immunol |volume=7 |issue=4 |pages=317–23 |date=August 2007 |pmid=17620823 |doi=10.1097/ACI.0b013e3282370c5f |url=}} 6. ^{{cite journal |vauthors=Tassaneeyakul W, Jantararoungtong T, Chen P, Lin PY, Tiamkao S, Khunarkornsiri U, Chucherd P, Konyoung P, Vannaprasaht S, Choonhakarn C, Pisuttimarn P, Sangviroon A, Tassaneeyakul W | title=Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai population | journal=Pharmacogenet Genomics | year=2009 | pages=704–9 |issue=9 | volume=19 | pmid=19696695 | doi=10.1097/FPC.0b013e328330a3b8 |url=}} 7. ^{{cite journal |author=Hung SI |title=HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue=11 |pages=4134–9 |date=March 2005 |pmid=15743917 |pmc=554812 |doi=10.1073/pnas.0409500102 |url= |name-list-format=vanc|author2=Chung WH |author3=Liou LB |display-authors=3 |last4=Chu |first4=CC |last5=Lin |first5=M |last6=Huang |first6=HP |last7=Lin |first7=YL |last8=Lan |first8=JL |last9=Yang |first9=LC}} 8. ^{{cite journal |author=Lonjou C |title=A European study of HLA-B in Stevens–Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs |journal=Pharmacogenet. Genomics |volume=18 |issue=2 |pages=99–107 |date=February 2008 |pmid=18192896 |doi=10.1097/FPC.0b013e3282f3ef9c |url= |name-list-format=vanc|author2=Borot N |author3=Sekula P |display-authors=3 |last4=Ledger |first4=Neil |last5=Thomas |first5=Laure |last6=Halevy |first6=Sima |last7=Naldi |first7=Luigi |last8=Bouwes-Bavinck |first8=Jan-Nico |last9=Sidoroff |first9=Alexis}} 2 : HLA-B alleles|Drug-sensitivity genes |
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