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词条 HLA-B62
释义

  1. Serotype

  2. Alleles

  3. References

{{Further2|HLA-serotype tutorial}}
HLA-B62 with bound peptide
major histocompatibility complex (human), class I, B62
Alleles*1501, *1504, *1507, *1525
Structure (See HLA-B)
Shared data
Locuschr.6 [https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p21.31 6p21.31]
HLA-B62 (B62) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.[1]

B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507 B*1525 and B*1533 allele products.

Serotype

Serotypes B15, B62, B63, B70, B71, B72, B75, B76, B77
recognition of the HLA B*15 gene products[2]
B*15B15B62B63B70B71B72B75B76B77Sample
allele % % % % % % % % % size (N)
{{HBA|1501}} 2 96 1906
{{HBA|1504}} 10 69 29
{{HBA|1505}} 18 64 22
{{HBA|1506}} 40 20 11 10
{{HBA|1507}} 79 101
{{HBA|1508}} 20 18 45
{{HBA|1511}} 15 27 21 68
{{HBA|1512}} 17 18 8 12
{{HBA|1515}} 13 49 28 138
{{HBA|1520}} 100 5
{{HBA|1524}} 44 54
{{HBA|1525}} 7 74 8 116
{{HBA|1527}} 7 76 76
{{HBA|1528}} 14 57 14 7
{{HBA|1530}} 17 64 98
{{HBA|1531}} 50 12
{{HBA|1535}} 79 34
Allele B15 B62 B63 B70 B71 B72 B75 B76 B77 N
Alleles link-out to IMGT/HLA Databease at EBI
{{clear|left}}

Alleles

HLA B*1501 frequencies
freq
ref. Population(%)
[3] Japan Ainu Hokkaido29.0
Chihuahuan Tarahumara14.8
Autonomous Tibetans12.3
South Korea ( 3)10.5
Japan Central8.7
Japan pop37.5
USA North American Natives7.2
South Dakota Lakota Sioux7.1
Shijiazhuang Tianjian Han7.0
China Qinghai Hui6.8
Croatia6.7
Japan pop56.5
Portugal Centre6.0
Taiwan Rukai6.0
USA Alaska Yupik Natives5.8
Australia New South Wales5.6
USA European Americans (2)5.6
France South East5.5
China Beijing5.3
Czech Republic4.7
Ireland South4.6
Mexico Sonora Seri4.5
China Inner Mongolia4.4
Russia Tuva (2)4.2
Singapore Chinese4.0
Taiwan Paiwan3.9
China North Han3.8
Georgia Svaneti Svans3.8
Ireland Northern3.8
Italy North Pavia3.7
Mexico Mestizos3.7
Azores Central Islands3.6
Madeira3.5
Taiwan Minnan pop 13.4
Azores Terceira Island3.1
Taiwan Siraya2.9
USA Hispanic2.8
Taiwan Hakka2.7
Taiwan Pazeh2.7
China Yunnan Nu2.6
Uganda Kampala2.5
Argentina Toba Rosario2.3
Romanian2.3
Hong Kong Chinese2.2
India North Hindus1.9
New Caledonia1.9
Italy South Campania1.8
Taiwan Thao1.7
India North Delhi1.6
China Guangzhou1.5
China Guangxi Maonan1.4
China Yunnan Lisu1.4
Thailand1.4
PNG New Britain Rabaul1.3
Brazil Belo Horizonte1.1
Cameroon Yaounde1.1
Portugal North1.1
United Arab Emerates1.1
Thailand pop31.0
USA African America1.0
USA African Americans1.0
Indig. Australian Yuendumu0.8
PNG Wanigela0.8
Mexico Zaptotec Oaxaca0.7
Spain Eastern Andalusia0.6
South African Natal Zulu0.5
Spain E. Andalusia Gipsy0.5
Sudanese0.5
Taiwan Bunun0.5
HLA B*1515 frequencies
freq
ref. Population(%)
[3] Mexico Mestizos2.4
Mex. Guadalajara Mestizos (2)1.9
Argentina Toba Rosario1.2
China Guangdong Meizhou Han1.0
China North Han1.0
Cape Verde NW Islands0.8
USA South Texas Hispanics0.8
USA San Antonio Caucasians0.6
USA Hispanic0.4
USA Asian0.3
USA North American Natives0.3
USA African America0.2
Hong Kong Chinese0.1
{{clear|right}}
HLA B*1525 frequencies
freq
ref. Population(%)
[3] Taiwan Tao40.0
Taiwan Thao11.7
Taiwan Pazeh10.9
China Yunnan Lisu8.7
China Yunnan Nu8.3
PNG West Schrader Ranges8.2
Indig. Australian Groote Eylandt8.0
Taiwan Puyuma7.0
Taiwan Rukai7.0
Taiwan Bunun6.4
Indig. Australian Yuendumu5.7
Taiwan Siraya4.9
Taiwan Tsou4.9
Philippines Ivatan3.0
Taiwan Atayal2.8
Taiwan Ami2.6
Thailand2.5
China Guangzhou2.0
Thailand pop32.0
Hong Kong Chinese1.9
PNG Wanigela1.5
PNG Wosera1.5
Singapore Thai1.5
India Andhra Pradesh Golla1.4
PNG Eastern Highlands Goroka1.4
China South Han1.1
China Inner Mongolia1.0
India North Hindus1.0
{{clear|right}}
HLA B*1507 frequencies
freq
ref. Population(%)
[3] Argentina Toba Rosario8.1
New Mexico Canoncito Navajo3.7
Brazil Terena2.6
USA North American Natives0.8
Japan Central0.7
South Korea pop 30.6
Japan pop30.4
USA Asian0.4
Shijiazhuang Tianjian Han0.3
USA Caucasian pop20.2
Hong Kong Chinese0.1
Ireland Northern0.1

References

1. ^{{cite journal | author = Marsh SG | title = Nomenclature for factors of the HLA system, 2004 | journal = Tissue Antigens | volume = 65 | issue = 4 | pages = 301–69 | year = 2005 | pmid = 15787720 | pmc = 2396006 | doi = 10.1111/j.1399-0039.2005.00379.x |name-list-format=vanc| author2 = Albert ED | author3 = Bodmer WF | display-authors = 3 | last4 = Bontrop | first4 = R.E. | last5 = Dupont | first5 = B. | last6 = Erlich | first6 = H.A. | last7 = Geraghty | first7 = D.E. | last8 = Hansen | first8 = J.A. | last9 = Hurley | first9 = C.K. }}
2. ^derived from IMGT/HLA
3. ^1 2 3 {{cite journal |vauthors=Middleton D, Menchaca L, Rood H, Komerofsky R | title = New allele frequency database: http://www.allelefrequencies.net | journal = Tissue Antigens | volume = 61 | issue = 5 | pages = 403–7 | year = 2003 | pmid = 12753660 | doi =10.1034/j.1399-0039.2003.00062.x }}
{{HLA-B serotypes}}

1 : HLA-B*15 serotypes
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