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词条 HLA-DOB
释义

  1. References

  2. Further reading

{{Infobox_gene}}HLA class II histocompatibility antigen, DO beta chain is a protein that in humans is encoded by the HLA-DOB gene.[1]

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.[1]

References

1. ^1 {{cite web | title = Entrez Gene: HLA-DOB major histocompatibility complex, class II, DO beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3112| accessdate = }}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Beck S, Kelly A, Radley E, etal |title=DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. |journal=J. Mol. Biol. |volume=228 |issue= 2 |pages= 433–41 |year= 1992 |pmid= 1453454 |doi=10.1016/0022-2836(92)90832-5 }}
  • {{cite journal |vauthors=Piatier-Tonneau D, Gastinel LN, Amblard F, etal |title=Interaction of CD4 with HLA class II antigens and HIV gp120. |journal=Immunogenetics |volume=34 |issue= 2 |pages= 121–8 |year= 1991 |pmid= 1869305 |doi= 10.1007/BF00211424}}
  • {{cite journal |vauthors=Rosenstein Y, Burakoff SJ, Herrmann SH |title=HIV-gp120 can block CD4-class II MHC-mediated adhesion. |journal=J. Immunol. |volume=144 |issue= 2 |pages= 526–31 |year= 1990 |pmid= 1967269 |doi= }}
  • {{cite journal |vauthors=Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ |title=Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 22 |pages= 9052–6 |year= 1991 |pmid= 1978941 |doi=10.1073/pnas.87.22.9052 | pmc=55099 }}
  • {{cite journal |vauthors=Jonsson AK, Rask L |title=Human class II DNA and DOB genes display low sequence variability |journal=Immunogenetics |volume=29 |issue= 6 |pages= 411–3 |year= 1989 |pmid= 2499532 |doi=10.1007/BF00375872 }}
  • {{cite journal |vauthors=Clayton LK, Sieh M, Pious DA, Reinherz EL |title=Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding |journal=Nature |volume=339 |issue= 6225 |pages= 548–51 |year= 1989 |pmid= 2543930 |doi= 10.1038/339548a0 }}
  • {{cite journal |vauthors=Diamond DC, Sleckman BP, Gregory T, etal |title=Inhibition of CD4+ T cell function by the HIV envelope protein, gp120 |journal=J. Immunol. |volume=141 |issue= 11 |pages= 3715–7 |year= 1988 |pmid= 2846691 |doi= }}
  • {{cite journal |vauthors=Tonnelle C, DeMars R, Long EO |title=DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression |journal=EMBO J. |volume=4 |issue= 11 |pages= 2839–47 |year= 1986 |pmid= 2998758 |doi= | pmc=554587 }}
  • {{cite journal |vauthors=Servenius B, Rask L, Peterson PA |title=Class II genes of the human major histocompatibility complex. The DO beta gene is a divergent member of the class II beta gene family |journal=J. Biol. Chem. |volume=262 |issue= 18 |pages= 8759–66 |year= 1987 |pmid= 3036827 |doi= }}
  • {{cite journal |vauthors=Andrieu JM, Even P, Venet A |title=AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications |journal=AIDS research |volume=2 |issue= 3 |pages= 163–74 |year= 1986 |pmid= 3489470 |doi= 10.1089/aid.1.1986.2.163}}
  • {{cite journal |vauthors=Houlgatte R, Scarmato P, el Marhomy S, etal |title=HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4 |journal=J. Immunol. |volume=152 |issue= 9 |pages= 4475–88 |year= 1994 |pmid= 7512597 |doi= }}
  • {{cite journal |vauthors=Chirmule N, McCloskey TW, Hu R, etal |title=HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71) |journal=J. Immunol. |volume=155 |issue= 2 |pages= 917–24 |year= 1995 |pmid= 7541827 |doi= }}
  • {{cite journal |vauthors=Rowell JF, Stanhope PE, Siliciano RF |title=Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC |journal=J. Immunol. |volume=155 |issue= 1 |pages= 473–88 |year= 1995 |pmid= 7602119 |doi= }}
  • {{cite journal |vauthors=Chen YH, Böck G, Vornhagen R, etal |title=HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41 |journal=Mol. Immunol. |volume=31 |issue= 13 |pages= 977–82 |year= 1994 |pmid= 8084338 |doi=10.1016/0161-5890(94)90092-2 }}
  • {{cite journal |vauthors=Chirmule N, Wang XP, Hu R, etal |title=Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help |journal=Cell. Immunol. |volume=155 |issue= 1 |pages= 169–82 |year= 1994 |pmid= 8168144 |doi= 10.1006/cimm.1994.1110 }}
  • {{cite journal |vauthors=Callahan KM, Rowell JF, Soloski MJ, etal |title=HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes |journal=J. Immunol. |volume=151 |issue= 6 |pages= 2928–42 |year= 1993 |pmid= 8376762 |doi= }}
  • {{cite journal |vauthors=Glynne R, Kerr LA, Mockridge I, etal |title=The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing |journal=Eur. J. Immunol. |volume=23 |issue= 4 |pages= 860–6 |year= 1993 |pmid= 8458375 |doi=10.1002/eji.1830230414 }}
  • {{cite journal |vauthors=Beck S, Abdulla S, Alderton RP, etal |title=Evolutionary dynamics of non-coding sequences within the class II region of the human MHC |journal=J. Mol. Biol. |volume=255 |issue= 1 |pages= 1–13 |year= 1996 |pmid= 8568858 |doi= 10.1006/jmbi.1996.0001 }}
  • {{cite journal |vauthors=Liljedahl M, Kuwana T, Fung-Leung WP, etal |title=HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport |journal=EMBO J. |volume=15 |issue= 18 |pages= 4817–24 |year= 1996 |pmid= 8890155 |doi= | pmc=452218 }}
  • {{cite journal |vauthors=Ruff AL, Guarnieri FG, Staveley-O'Carroll K, etal |title=The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8671–8 |year= 1997 |pmid= 9079699 |doi=10.1074/jbc.272.13.8671 }}
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1 : MHC Class II
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