| 释义 |
- Function
- References
- Further reading
- External links
{{DISPLAYTITLE:HLF (gene)}}{{Infobox_gene}}Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[1][2] Function This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3] References 1. ^{{cite journal | vauthors = Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT | title = Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia | journal = Science | volume = 257 | issue = 5069 | pages = 531–4 | date = July 1992 | pmid = 1386162 | pmc = | doi = 10.1126/science.1386162 }}
2. ^{{cite web | title = Entrez Gene: HLF hepatic leukemia factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3131| accessdate = }}
3. ^{{cite web | title = Entrez Gene: HLF hepatic leukemia factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3131| accessdate = }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = LeBrun DP | title = E2A basic helix-loop-helix transcription factors in human leukemia | journal = Frontiers in Bioscience | volume = 8 | issue = | pages = s206-22 | date = May 2003 | pmid = 12700034 | doi = 10.2741/1030 }}
- {{cite journal | vauthors = Hunger SP, Ohyashiki K, Toyama K, Cleary ML | title = Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia | journal = Genes & Development | volume = 6 | issue = 9 | pages = 1608–20 | date = September 1992 | pmid = 1516826 | doi = 10.1101/gad.6.9.1608 }}
- {{cite journal | vauthors = Falvey E, Fleury-Olela F, Schibler U | title = The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences | journal = The EMBO Journal | volume = 14 | issue = 17 | pages = 4307–17 | date = September 1995 | pmid = 7556072 | pmc = 394515 | doi = }}
- {{cite journal | vauthors = Hunger SP, Brown R, Cleary ML | title = DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF | journal = Molecular and Cellular Biology | volume = 14 | issue = 9 | pages = 5986–96 | date = September 1994 | pmid = 8065331 | pmc = 359124 | doi = 10.1128/mcb.14.9.5986 }}
- {{cite journal | vauthors = Inaba T, Shapiro LH, Funabiki T, Sinclair AE, Jones BG, Ashmun RA, Look AT | title = DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein | journal = Molecular and Cellular Biology | volume = 14 | issue = 5 | pages = 3403–13 | date = May 1994 | pmid = 8164688 | pmc = 358705 | doi = }}
- {{cite journal | vauthors = Hunger SP | title = Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis | journal = Blood | volume = 87 | issue = 4 | pages = 1211–24 | date = February 1996 | pmid = 8608207 | doi = }}
- {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–13 | date = April 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
- {{cite journal | vauthors = Hunger SP, Li S, Fall MZ, Naumovski L, Cleary ML | title = The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties | journal = Blood | volume = 87 | issue = 11 | pages = 4607–17 | date = June 1996 | pmid = 8639829 | doi = }}
- {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = April 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
- {{cite journal | vauthors = Takahata S, Sogawa K, Kobayashi A, Ema M, Mimura J, Ozaki N, Fujii-Kuriyama Y | title = Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock | journal = Biochemical and Biophysical Research Communications | volume = 248 | issue = 3 | pages = 789–94 | date = July 1998 | pmid = 9704006 | doi = 10.1006/bbrc.1998.9012 }}
- {{cite journal | vauthors = Inukai T, Inaba T, Ikushima S, Look AT | title = The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF | journal = Molecular and Cellular Biology | volume = 18 | issue = 10 | pages = 6035–43 | date = October 1998 | pmid = 9742120 | pmc = 109189 | doi = }}
- {{cite journal | vauthors = Begbie M, Mueller C, Lillicrap D | title = Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes | journal = DNA and Cell Biology | volume = 18 | issue = 2 | pages = 165–73 | date = February 1999 | pmid = 10073576 | doi = 10.1089/104454999315556 }}
- {{cite journal | vauthors = Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y | title = Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300 | journal = The EMBO Journal | volume = 18 | issue = 7 | pages = 1905–14 | date = April 1999 | pmid = 10202154 | pmc = 1171276 | doi = 10.1093/emboj/18.7.1905 }}
- {{cite journal | vauthors = Honda H, Inaba T, Suzuki T, Oda H, Ebihara Y, Tsuiji K, Nakahata T, Ishikawa T, Yazaki Y, Hirai H | title = Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia | journal = Blood | volume = 93 | issue = 9 | pages = 2780–90 | date = May 1999 | pmid = 10216071 | doi = }}
- {{cite journal | vauthors = Matsunaga T, Inaba T, Matsui H, Okuya M, Miyajima A, Inukai T, Funabiki T, Endo M, Look AT, Kurosawa H | title = Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein | journal = Blood | volume = 103 | issue = 8 | pages = 3185–91 | date = April 2004 | pmid = 15070701 | doi = 10.1182/blood-2003-09-3022 }}
{{refend}} External links - {{MeshName|HLF+protein,+human}}
{{NLM content}}{{Transcription factors|g1}}{{gene-17-stub}} 1 : Transcription factors |