| 词条 | Homochlorcyclizine |
| 释义 |
| IUPAC_name = 1-[(4-chlorophenyl)-phenylmethyl]-4-methyl-1,4-diazepane | image = Homochlorcyclizine.svg | tradename = | Drugs.com = {{drugs.com|international|homochlorcyclizine}} | pregnancy_category = | legal_status = Rx-only | routes_of_administration = Oral | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number = 848-53-3 | ATC_prefix = none | ATC_suffix = | PubChem = 3627 | ChemSpiderID = 3501 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = N5MVC31W2N | KEGG = D08041 | ChEMBL = 151447 | C=19 | H=23 | Cl=1 | N=2 | molecular_weight = 314.85 g/mol | smiles = CN1CCCN(CC1)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl }}Homochlorcyclizine (INN) is an antihistamine of the diphenylmethylpiperazine group which has been marketed in Japan since 1965.[1] It is used in the treatment of allergies and other conditions. It also has some anticholinergic, antidopaminergic, and antiserotonergic properties.[2][3] See also
References1. ^{{cite web |url=http://di.eisai.co.jp/di/EPI/HC_T_EPI.pdf |title=Homoclomin Tablets 10 mg |date=December 2007 |publisher=Eisai Co. |accessdate=2008-07-29}} {{Dead link|date=October 2010|bot=H3llBot}} {{Antihistamines}}{{Cholinergics}}{{Histaminergics}}{{Serotonergics}}2. ^{{cite journal |vauthors=Haraguchi K, Ito K, Kotaki H, Sawada Y, Iga T | title = Prediction of drug-induced catalepsy based on dopamine D1, D2, and muscarinic acetylcholine receptor occupancies | journal = Drug Metabolism and Disposition | volume = 25 | issue = 6 | pages = 675–84 |date=June 1997 | pmid = 9193868 | doi = | url = http://dmd.aspetjournals.org/cgi/pmidlookup?view=long&pmid=9193868}} 3. ^{{cite journal |vauthors=KIMURA ET, YOUNG PR, RICHARDS RK | title = Pharmacologic properties of N-p-chloro-benzhydryl-N'-methyl homopiperazine dihydrochloride (homochlorcyclizine; SA-97), a serotonin antagonist | journal = Journal of Allergy | volume = 31 | issue = | pages = 237–47 | year = 1960 | pmid = 14409112 | doi = | url = }} 3 : H1 receptor antagonists|Chloroarenes|Diazepanes |
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