“HOXB9”的意思、由来-开放百科全书

Function

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer.^[3]

References

1. ^{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 | date = August 1990 | pmid = 1973146 | pmc = | doi = 10.1016/0888-7543(90)90186-X }}
2. ^{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 | date = December 1992 | pmid = 1358459 | pmc = | doi = 10.1016/0092-8674(92)90588-4 }}
3. ^¹{{cite web | title = Entrez Gene: HOXB9 homeobox B9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3219| accessdate = }}
4. ^¹{{cite journal | vauthors = Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, Corbo L | title = The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation | journal = J. Biol. Chem. | volume = 275 | issue = 1 | pages = 147–53 | date = January 2000 | pmid = 10617598 | doi = 10.1074/jbc.275.1.147 }}

Further reading

{{cite journal | vauthors = Deguchi Y, Kehrl JH | title = Selective expression of two homeobox genes in CD34-positive cells from human bone marrow | journal = Blood | volume = 78 | issue = 2 | pages = 323–8 | year = 1991 | pmid = 1712647 | doi = }}

{{cite journal | vauthors = Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A | title = Expression of HOX homeogenes in human neuroblastoma cell culture lines | journal = Differentiation | volume = 45 | issue = 1 | pages = 61–9 | year = 1990 | pmid = 1981366 | doi = 10.1111/j.1432-0436.1990.tb00458.x }}

{{cite journal | vauthors = Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A | title = Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system | journal = Differentiation | volume = 40 | issue = 3 | pages = 191–7 | year = 1989 | pmid = 2570724 | doi = 10.1111/j.1432-0436.1989.tb00598.x }}

{{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Res. | volume = 17 | issue = 24 | pages = 10385–402 | year = 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}

{{cite journal | vauthors = Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A | title = Organization of human class I homeobox genes | journal = Genome | volume = 31 | issue = 2 | pages = 745–56 | year = 1989 | pmid = 2576652 | doi = 10.1139/g89-133 }}

{{cite journal | vauthors = Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B | title = Fine mapping of human HOX gene clusters | journal = Cytogenet. Cell Genet. | volume = 73 | issue = 1-2 | pages = 114–5 | year = 1996 | pmid = 8646877 | doi = 10.1159/000134320 }}

{{cite journal | vauthors = Ohnishi K, Tobita T, Sinjo K, Takeshita A, Ohno R | title = Modulation of homeobox B6 and B9 genes expression in human leukemia cell lines during myelomonocytic differentiation | journal = Leuk. Lymphoma | volume = 31 | issue = 5-6 | pages = 599–608 | year = 1998 | pmid = 9922051 | doi = 10.3109/10428199809057620 }}

{{cite journal | vauthors = Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, Corbo L | title = The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation | journal = J. Biol. Chem. | volume = 275 | issue = 1 | pages = 147–53 | year = 2000 | pmid = 10617598 | doi = 10.1074/jbc.275.1.147 }}

{{cite journal | vauthors = Calvo R, West J, Franklin W, Erickson P, Bemis L, Li E, Helfrich B, Bunn P, Roche J, Brambilla E, Rosell R, Gemmill RM, Drabkin HA | title = Altered HOX and WNT7A expression in human lung cancer | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 23 | pages = 12776–81 | year = 2000 | pmid = 11070089 | pmc = 18840 | doi = 10.1073/pnas.97.23.12776 }}

{{cite journal | vauthors = de Pinieux G, Legrier ME, Poirson-Bichat F, Courty Y, Bras-Gonçalves R, Dutrillaux AM, Némati F, Oudard S, Lidereau R, Broqua P, Junien JL, Dutrillaux B, Poupon MF | title = Clinical and experimental progression of a new model of human prostate cancer and therapeutic approach | journal = Am. J. Pathol. | volume = 159 | issue = 2 | pages = 753–64 | year = 2001 | pmid = 11485933 | pmc = 1850557 | doi = 10.1016/S0002-9440(10)61746-4 }}

{{cite journal | vauthors = Shen WF, Krishnan K, Lawrence HJ, Largman C | title = The HOX homeodomain proteins block CBP histone acetyltransferase activity | journal = Mol. Cell. Biol. | volume = 21 | issue = 21 | pages = 7509–22 | year = 2001 | pmid = 11585930 | pmc = 99922 | doi = 10.1128/MCB.21.21.7509-7522.2001 }}

{{cite journal | vauthors = Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N | title = Complete mutation analysis panel of the 39 human HOX genes | journal = Teratology | volume = 65 | issue = 2 | pages = 50–62 | year = 2002 | pmid = 11857506 | doi = 10.1002/tera.10009 }}

{{cite journal| vauthors = Hori Y, Gu X, Xie X, Kim SK | title = Differentiation of insulin-producing cells from human neural progenitor cells | journal = PLoS Med. | volume = 2 | issue = 4 | pages = e103 | year = 2005 | pmid = 15839736 | pmc = 1087208 | doi = 10.1371/journal.pmed.0020103 }}

{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}

{{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}

Function

Interactions

See also

References

Further reading

External links