| 释义 |
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis.[3]
}}See alsoReferences1. ^{{cite journal |vauthors=McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 |date=Aug 1990 | pmid = 1973146 | pmc = | doi =10.1016/0888-7543(90)90186-X }}
2. ^{{cite journal | author = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 |date=Dec 1992 | pmid = 1358459 | pmc = | doi =10.1016/0092-8674(92)90588-4 }}
3. ^1 {{cite web | title = Entrez Gene: HOXD1 homeobox D1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3231| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Boncinelli E, Acampora D, Pannese M, etal |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745–56 |year= 1990 |pmid= 2576652 |doi= 10.1139/g89-133}}
- {{cite journal |vauthors=Manohar CF, Salwen HR, Furtado MR, Cohn SL |title=Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation. |journal=Tumour Biol. |volume=17 |issue= 1 |pages= 34–47 |year= 1996 |pmid= 7501971 |doi=10.1159/000217965 }}
- {{cite journal |vauthors=Guazzi S, Lonigro R, Pintonello L, etal |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339–47 |year= 1994 |pmid= 7913891 |doi= | pmc=395231 }}
- {{cite journal |vauthors=Manohar CF, Furtado MR, Salwen HR, Cohn SL |title=Hox gene expression in differentiating human neuroblastoma cells. |journal=Biochem. Mol. Biol. Int. |volume=30 |issue= 4 |pages= 733–41 |year= 1993 |pmid= 8104620 |doi= }}
- {{cite journal |vauthors=Del Campo M, Jones MC, Veraksa AN, etal |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster. |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104–10 |year= 1999 |pmid= 10364522 |doi=10.1086/302467 | pmc=1378080 }}
- {{cite journal |vauthors=Adjaye J, Monk M |title=Transcription of homeobox-containing genes detected in cDNA libraries derived from human unfertilized oocytes and preimplantation embryos. |journal=Mol. Hum. Reprod. |volume=6 |issue= 8 |pages= 707–11 |year= 2000 |pmid= 10908280 |doi=10.1093/molehr/6.8.707 }}
- {{cite journal |vauthors=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1-2 |pages= 151–3 |year= 2000 |pmid= 11060466 |doi=10.1159/000015651 }}
- {{cite journal |vauthors=Appukuttan B, Sood R, Ott S, etal |title=Isolation and characterization of the human homeobox gene HOX D1. |journal=Mol. Biol. Rep. |volume=27 |issue= 4 |pages= 195–201 |year= 2001 |pmid= 11455954 |doi=10.1023/A:1011048931477 }}
- {{cite journal |vauthors=Pitera JE, Milla PJ, Scambler P, Adjaye J |title=Cloning of HOXD1 from unfertilised human oocytes and expression analyses during murine oogenesis and embryogenesis. |journal=Mech. Dev. |volume=109 |issue= 2 |pages= 377–81 |year= 2002 |pmid= 11731253 |doi=10.1016/S0925-4773(01)00530-5 }}
- {{cite journal |vauthors=Kosaki K, Kosaki R, Suzuki T, etal |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
{{refend}} External links - {{MeshName|HOXD1+protein,+human}}
{{NLM content}}{{Transcription factors|g3}}{{gene-2-stub}} 1 : Transcription factors |