| 释义 |
- References
- Further reading
- External links
{{Infobox_gene}}5-hydroxytryptamine (serotonin) receptor 3B, also known as HTR3B, is a human gene. The protein encoded by this gene is a subunit of the 5-HT3 receptor.[1][2]References1. ^{{cite journal |vauthors=Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF | title = The 5-HT3B subunit is a major determinant of serotonin-receptor function | journal = Nature | volume = 397 | issue = 6717 | pages = 359–63 |date=January 1999 | pmid = 9950429 | doi = 10.1038/16941 | url = }}
2. ^{{cite journal |vauthors=Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, Jackson MR, Lovenberg TW, Erlander MG | title = The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit | journal = J. Biol. Chem. | volume = 274 | issue = 43 | pages = 30799–810 |date=October 1999 | pmid = 10521471 | doi = 10.1074/jbc.274.43.30799}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Need AC, Keefe RS, Ge D, etal |title=Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis |journal=Eur. J. Hum. Genet. |volume=17 |issue= 7 |pages= 946–57 |year= 2009 |pmid= 19156168 |doi= 10.1038/ejhg.2008.264 |pmc=2986499 }}
- {{cite journal |vauthors=Meineke C, Tzvetkov MV, Bokelmann K, etal |title=Functional characterization of a -100_-102delAAG deletion-insertion polymorphism in the promoter region of the HTR3B gene |journal=Pharmacogenet. Genomics |volume=18 |issue= 3 |pages= 219–30 |year= 2008 |pmid= 18300944 |doi= 10.1097/FPC.0b013e3282f51092 }}
- {{cite journal |vauthors=Levran O, Londono D, O'Hara K, etal |title=Genetic susceptibility to heroin addiction; a candidate-gene association study |journal=Genes, Brain and Behavior |volume=7 |issue= 7 |pages= 720–9 |year= 2008 |pmid= 18518925 |doi= 10.1111/j.1601-183X.2008.00410.x |pmc=2885890 }}
- {{cite journal |vauthors=Kato M, Fukuda T, Wakeno M, etal |title=Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients |journal=Neuropsychobiology |volume=53 |issue= 4 |pages= 186–95 |year= 2006 |pmid= 16874005 |doi= 10.1159/000094727 }}
- {{cite journal |vauthors=Hu XQ, Peoples RW |title=The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor |journal=J. Biol. Chem. |volume=283 |issue= 11 |pages= 6826–31 |year= 2008 |pmid= 18187416 |doi= 10.1074/jbc.M707571200 }}
- {{cite journal |vauthors=Krzywkowski K, Davies PA, Feinberg-Zadek PL, etal |title=High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=105 |issue= 2 |pages= 722–7 |year= 2008 |pmid= 18184810 |doi= 10.1073/pnas.0708454105 |pmc=2206603 }}
- {{cite journal |vauthors=Ji X, Takahashi N, Branko A, etal |title=An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population |journal=Nagoya Journal of Medical Science |volume=70 |issue= 1–2 |pages= 11–7 |year= 2008 |pmid= 18807291 |doi= }}
- {{cite journal |vauthors=Kato M, Serretti A |title=Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder |journal=Mol. Psychiatry |volume= 15|issue= 5|pages= 473–500 |year= 2008 |pmid= 18982004 |doi= 10.1038/mp.2008.116 }}
- {{cite journal |vauthors=Walstab J, Hammer C, Bönisch H, etal |title=Naturally occurring variants in the HTR3B gene significantly alter properties of human heteromeric 5-hydroxytryptamine-3A/B receptors |journal=Pharmacogenet. Genomics |volume=18 |issue= 9 |pages= 793–802 |year= 2008 |pmid= 18698232 |doi= 10.1097/FPC.0b013e3283050117 }}
- {{cite journal |vauthors=Yosifova A, Mushiroda T, Stoianov D, etal |title=Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population |journal=Journal of Affective Disorders |volume=117 |issue= 1–2 |pages= 87–97 |year= 2009 |pmid= 19328558 |doi= 10.1016/j.jad.2008.12.021 }}
- {{cite journal |vauthors=Tzvetkov MV, Meineke C, Oetjen E, etal |title=Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine |journal=Gene |volume=386 |issue= 1–2 |pages= 52–62 |year= 2007 |pmid= 17010535 |doi= 10.1016/j.gene.2006.08.002 }}
- {{cite journal |vauthors=Oades RD, Lasky-Su J, Christiansen H, etal |title=The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis |journal=Behavioral and Brain Functions |volume=4 |issue= |pages= 48 |year= 2008 |pmid= 18937842 |doi= 10.1186/1744-9081-4-48 |pmc=2577091 }}
- {{cite journal |vauthors=Fasching PA, Kollmannsberger B, Strissel PL, etal |title=Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy |journal=J. Cancer Res. Clin. Oncol. |volume=134 |issue= 10 |pages= 1079–86 |year= 2008 |pmid= 18389280 |doi= 10.1007/s00432-008-0387-1 }}
- {{cite journal |vauthors=Tanaka M, Kobayashi D, Murakami Y, etal |title=Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea |journal=Int. J. Neuropsychopharmacol. |volume=11 |issue= 2 |pages= 261–7 |year= 2008 |pmid= 17697394 |doi= 10.1017/S1461145707007985 }}
- {{cite journal |vauthors=Gratacòs M, Costas J, de Cid R, etal |title=Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=150B |issue= 6 |pages= 808–16 |year= 2009 |pmid= 19086053 |doi= 10.1002/ajmg.b.30902 }}
- {{cite journal |vauthors=Krzywkowski K, Davies PA, Irving AJ, etal |title=Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling |journal=Pharmacogenet. Genomics |volume=18 |issue= 12 |pages= 1027–40 |year= 2008 |pmid= 19008750 |doi= 10.1097/FPC.0b013e328310f950 }}
- {{cite journal |vauthors=Smith AK, Dimulescu I, Falkenberg VR, etal |title=Genetic evaluation of the serotonergic system in chronic fatigue syndrome |journal=Psychoneuroendocrinology |volume=33 |issue= 2 |pages= 188–97 |year= 2008 |pmid= 18079067 |doi= 10.1016/j.psyneuen.2007.11.001 }}
- {{cite journal |vauthors=de Krom M, Staal WG, Ophoff RA, etal |title=A common variant in DRD3 receptor is associated with autism spectrum disorder |journal=Biol. Psychiatry |volume=65 |issue= 7 |pages= 625–30 |year= 2009 |pmid= 19058789 |doi= 10.1016/j.biopsych.2008.09.035 }}
- {{cite journal |vauthors=Ducci F, Enoch MA, Yuan Q, etal |title=HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power—an intermediate phenotype for alcoholism and co-morbid behaviors |journal=Alcohol |volume=43 |issue= 1 |pages= 73–84 |year= 2009 |pmid= 19185213 |doi= 10.1016/j.alcohol.2008.09.005 |pmc=2754808 }}
{{refend}}External links- {{MeshName|HTR3B+protein,+human}}
{{Ligand-gated ion channels}}{{transmembranereceptor-stub}} 2 : Serotonin receptors|Ion channels |