“HYAL2”的意思、由来-开放百科全书

This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. Varying functions have been described for this protein. It has been described as a lysosomal hyaluronidase which is active at a pH below 4 and specifically hydrolyzes high molecular weight hyaluronan. It has also been described as a GPI-anchored cell surface protein which does not display hyaluronidase activity but does serve as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.^[3]

One study found associations between cleft lip and palate and mutations in the HYAL2 gene.^[4]

An investigation published in 2017, attributed an additional function to the Hyaluronidase 2 (HYAL2) protein. The study found interactions between HYAL2 and proteins involved in the alternative splicing of CD44 pre-mRNA,^[5] suggesting a broader regulatory role for the HYAL2 protein in cell biology.

References

1. ^{{cite journal |vauthors=Lepperdinger G, Strobl B, Kreil G | title = HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity | journal = J Biol Chem | volume = 273 | issue = 35 | pages = 22466–70 |date=Sep 1998 | pmid = 9712871 | pmc = | doi =10.1074/jbc.273.35.22466 }}
2. ^{{cite journal |vauthors=Strobl B, Wechselberger C, Beier DR, Lepperdinger G | title = Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase | journal = Genomics | volume = 53 | issue = 2 | pages = 214–9 |date=Dec 1998 | pmid = 9790770 | pmc = | doi = 10.1006/geno.1998.5472 }}
3. ^¹{{cite web | title = Entrez Gene: HYAL2 hyaluronoglucosaminidase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8692| accessdate = }}
4. ^{{Cite news|url=http://www.medicalnewstoday.com/articles/315211.php|title=Scientists find genetic mutation that causes cleft lip and palate, heart defects|last=Sandoiu|first=Ana|date=2017-01-17|work=|newspaper=Medical News Today|language=en|access-date=2017-01-31|via=}}
5. ^{{Cite journal|last=Midgley|first=Adam C.|last2=Oltean|first2=Sebastian|last3=Hascall|first3=Vincent|last4=Woods|first4=Emma L.|last5=Steadman|first5=Robert|last6=Phillips|first6=Aled O.|last7=Meran|first7=Soma|date=2017-11-21|title=Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype|journal=Science Signaling|volume=10|issue=506|doi=10.1126/scisignal.aao1822|issn=1937-9145|pmid=29162741}}

Further reading

{{cite journal |vauthors=Lepperdinger G, Müllegger J, Kreil G |title=Hyal2--less active, but more versatile? |journal=Matrix Biol. |volume=20 |issue= 8 |pages= 509–14 |year= 2002 |pmid= 11731268 |doi=10.1016/S0945-053X(01)00170-6 }}

{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}

{{cite journal | author=Wei MH |title=Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG |journal=Cancer Res. |volume=56 |issue= 7 |pages= 1487–92 |year= 1996 |pmid= 8603390 |doi= |name-list-format=vanc| author2=Latif F | author3=Bader S | display-authors=3 | last4=Kashuba | first4=V | last5=Chen | first5=JY | last6=Duh | first6=FM | last7=Sekido | first7=Y | last8=Lee | first8=CC | last9=Geil | first9=L }}

{{cite journal | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |name-list-format=vanc| author2=Wentland MA | author3=Ricafrente JY | display-authors=3 | last4=Liu | first4=W | last5=Gibbs | first5=RA }}

{{cite journal | author=Yu W |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |name-list-format=vanc| author2=Andersson B | author3=Worley KC | display-authors=3 | last4=Muzny | first4=DM | last5=Ding | first5=Y | last6=Liu | first6=W | last7=Ricafrente | first7=JY | last8=Wentland | first8=MA | last9=Lennon | first9=G }}

{{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3 | last4=Suyama | first4=A | last5=Sugano | first5=S }}

{{cite journal | author=Sun L |title=Expression profile of hyaluronidase mRNA transcripts in the kidney and in renal cells |journal=Kidney Blood Press. Res. |volume=21 |issue= 6 |pages= 413–8 |year= 1999 |pmid= 9933825 |doi=10.1159/000025893 |name-list-format=vanc| author2=Feusi E | author3=Sibalic A | display-authors=3 | last4=Beck-Schimmer | first4=Beatrice | last5=wÜThrich | first5=Rudolf P. }}

{{cite journal |vauthors=Fiszer-Szafarz B, Litynska A, Zou L |title=Human hyaluronidases: electrophoretic multiple forms in somatic tissues and body fluids. Evidence for conserved hyaluronidase potential N-glycosylation sites in different mammalian species |journal=J. Biochem. Biophys. Methods |volume=45 |issue= 2 |pages= 103–16 |year= 2000 |pmid= 10989127 |doi=10.1016/S0165-022X(00)00067-1 }}

{{cite journal |vauthors=Lerman MI, Minna JD |title=The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium |journal=Cancer Res. |volume=60 |issue= 21 |pages= 6116–33 |year= 2000 |pmid= 11085536 |doi= }}

{{cite journal | author=Rai SK |title=Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 8 |pages= 4443–8 |year= 2001 |pmid= 11296287 |doi= 10.1073/pnas.071572898 | pmc=31854 |name-list-format=vanc| author2=Duh FM | author3=Vigdorovich V | display-authors=3 | last4=Danilkovitch-Miagkova | first4=A | last5=Lerman | first5=MI | last6=Miller | first6=AD }}

{{cite journal | author=Delpech B |title=Hyaluronidase is more elevated in human brain metastases than in primary brain tumours |journal=Anticancer Res. |volume=22 |issue= 4 |pages= 2423–7 |year= 2002 |pmid= 12174938 |doi= |name-list-format=vanc| author2=Laquerriere A | author3=Maingonnat C | display-authors=3 | last4=Bertrand | first4=P | last5=Freger | first5=P }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal |vauthors=Liu SL, Duh FM, Lerman MI, Miller AD |title=Role of virus receptor Hyal2 in oncogenic transformation of rodent fibroblasts by sheep betaretrovirus env proteins |journal=J. Virol. |volume=77 |issue= 5 |pages= 2850–8 |year= 2003 |pmid= 12584308 |doi=10.1128/JVI.77.5.2850-2858.2003 | pmc=149765 }}

{{cite journal | author=Danilkovitch-Miagkova A |title=Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4580–5 |year= 2003 |pmid= 12676986 |doi= 10.1073/pnas.0837136100 | pmc=153598 |name-list-format=vanc| author2=Duh FM | author3=Kuzmin I | display-authors=3 | last4=Angeloni | first4=D | last5=Liu | first5=SL | last6=Miller | first6=AD | last7=Lerman | first7=MI |hdl=11382/303276}}

{{cite journal |vauthors=Junker N, Latini S, Petersen LN, Kristjansen PE |title=Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines |journal=Oncol. Rep. |volume=10 |issue= 3 |pages= 609–16 |year= 2003 |pmid= 12684632 |doi= 10.3892/or.10.3.609 }}

{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }}

{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}