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词条 Hydrazine (antidepressant)
释义

  1. List of hydrazine antidepressants

     Marketed  Never marketed  Parkinson's  Tranquillosedative 

  2. References

{{About|a series of antidepressants|the toxic, unstable compound with the chemical formula N2H4|hydrazine}}

The hydrazine antidepressants are a group of non-selective, irreversible monoamine oxidase inhibitors (MAOIs) which were discovered and initially marketed in the 1950s and 1960s. Most have been withdrawn due to toxicity, namely hepatotoxicity, but a few still remain in clinical use.

Tranylcypromine, a structurally unrelated MAOI introduced around the same time as the hydrazines, was originally advertised as non-hydrazine as a result of its diminished propensity for causing hepatotoxicity.

List of hydrazine antidepressants

Marketed

{{colbegin}}
  • Benmoxin (Neuralex, Nerusil)
  • Iproclozide (Sursum)
  • Iproniazid (Marsilid)
  • Isocarboxazid (Marplan)
  • Mebanazine (Actomol)
  • Nialamide (Niamid)
  • Octamoxin (Ximaol, Nimaol)
  • Phenelzine (Nardil)
  • Pheniprazine (Catron)
  • Phenoxypropazine (Drazine)
  • Pivhydrazine (Tersavid)
  • Safrazine (Safra)
{{colend}}

Legend: = Withdrawn from the market; = Partially discontinued; Bolded names indicate major drugs.

Never marketed

  • Carbenzide
  • Cimemoxin
  • Domoxin
  • Metfendrazine

Parkinson's

  • Carbidopa

Tranquillosedative

  • Centazolone

References

  • {{cite journal |vauthors=López-Muñoz F, Alamo C | title = Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today | journal = Current Pharmaceutical Design | volume = 15 | issue = 14 | pages = 1563–86 | year = 2009 | pmid = 19442174 | doi = 10.2174/138161209788168001| url = http://www.bentham-direct.org/pages/content.php?CPD/2009/00000015/00000014/0002B.SGM}}
{{Antidepressants}}{{Hydrazines}}

4 : Hepatotoxins|Hydrazines|Monoamine oxidase inhibitors|Withdrawn drugs

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